Abstract：
:Neuroligins are postsynaptic cell adhesion molecules that are important for synaptic function through their trans-synaptic interaction with neurexins (NRXNs). The localization and synaptic effects of neuroligin-1 (NL-1, also called NLGN1) are specific to excitatory synapses with the capacity to enhance excitatory synapses dependent on synaptic activity or Ca(2+)/calmodulin kinase II (CaMKII). Here we report that CaMKII robustly phosphorylates the intracellular domain of NL-1. We show that T739 is the dominant CaMKII site on NL-1 and is phosphorylated in response to synaptic activity in cultured rodent neurons and sensory experience in vivo. Furthermore, a phosphodeficient mutant (NL-1 T739A) reduces the basal and activity-driven surface expression of NL-1, leading to a reduction in neuroligin-mediated excitatory synaptic potentiation. To the best of our knowledge, our results are the first to demonstrate a direct functional interaction between CaMKII and NL-1, two primary components of excitatory synapses.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Bemben MA,Shipman SL,Hirai T,Herring BE,Li Y,Badger JD 2nd,Nicoll RA,Diamond JS,Roche KWdoi
10.1038/nn.3601subject
Has Abstractpub_date
2014-01-01 00:00:00pages
56-64issue
1eissn
1097-6256issn
1546-1726pii
nn.3601journal_volume
17pub_type
杂志文章abstract：:Rapid eye movement (REM) sleep has been considered important for consolidation of memories, particularly of skills. Contrary to expectations, we found that REM sleep suppression by administration of selective serotonin or norepinephrine re-uptake inhibitors after training did not impair consolidation of skills or word...
journal_title：Nature neuroscience
pub_type： 临床试验,杂志文章,随机对照试验
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abstract：:The projections and odor responses of mammalian olfactory receptor neurons, as well as the physiology of the bulb's principal neurons-the mitral cells (MCs)-are known from studies in slices and anesthetized animals. In behaving rats trained to discriminate between two odors associated with different reinforcers, we ex...
journal_title：Nature neuroscience
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abstract：:Mutations in MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT). The RTT missense MECP2R306C mutation prevents MeCP2 from interacting with the NCoR/histone deacetylase 3 (HDAC3) complex; however, the neuronal function of HDAC3 is incompletely understood. We found that neuronal deletion of Hdac3 in mice el...
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更新日期：2016-11-01 00:00:00
abstract：:Information analysis shows that face-selective neurons in inferior temporal cortex encode different stimulus attributes early and late in their response to the same image. ...
journal_title：Nature neuroscience
pub_type： 杂志文章
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abstract：:It is widely held that color and motion are processed by separate parallel pathways in the visual system, but this view is difficult to reconcile with the fact that motion can be detected in equiluminant stimuli that are defined by color alone. To examine the relationship between color and motion, we tested three pati...
journal_title：Nature neuroscience
pub_type： 杂志文章
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journal_title：Nature neuroscience
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pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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journal_title：Nature neuroscience
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更新日期：2006-07-01 00:00:00
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journal_title：Nature neuroscience
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更新日期：2013-07-01 00:00:00
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更新日期：2004-12-01 00:00:00
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pub_type： 已发布勘误
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更新日期：2018-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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更新日期：2003-12-01 00:00:00
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