Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes.

abstract：:We report on two brain-damaged subjects who exhibit the uncommon pattern of loss of object color knowledge, but spared color perception and naming. The subject P.C.O., as in previously reported patients, is also impaired in processing other perceptual and functional properties of objects. I.O.C., in contrast, is the f...

journal_title：Nature neuroscience

authors： Miceli G,Fouch E,Capasso R,Shelton JR,Tomaiuolo F,Caramazza A

更新日期：2001-06-01 00:00:00

abstract：:In Huntington's disease (HD), expansion of CAG codons in the huntingtin gene (HTT) leads to the aberrant formation of protein aggregates and the differential degeneration of striatal medium spiny neurons (MSNs). Modeling HD using patient-specific MSNs has been challenging, as neurons differentiated from induced plurip...

journal_title：Nature neuroscience

authors： Victor MB,Richner M,Olsen HE,Lee SW,Monteys AM,Ma C,Huh CJ,Zhang B,Davidson BL,Yang XW,Yoo AS

更新日期：2018-03-01 00:00:00

abstract：:The morphological transition of growth cones to synaptic boutons characterizes synaptogenesis. Here we have isolated mutations in immaculate connections (imac; CG8566), a previously uncharacterized Drosophila gene encoding a member of the Kinesin-3 family. Whereas earlier studies in Drosophila implicated Kinesin-1 in ...

journal_title：Nature neuroscience

authors： Pack-Chung E,Kurshan PT,Dickman DK,Schwarz TL

更新日期：2007-08-01 00:00:00

abstract：:The orbitofrontal cortex plays a central role in good-based economic decisions. When subjects make choices, neurons in this region represent the identities and values of offered and chosen goods. Notably, choices in different behavioral contexts may involve a potentially infinite variety of goods. Thus a fundamental q...

journal_title：Nature neuroscience

authors： Xie J,Padoa-Schioppa C

更新日期：2016-06-01 00:00:00

abstract：:We introduce a deceptively simple behavioral task that robustly identifies two qualitatively different groups within the general population. When presented with an isochronous train of random syllables, some listeners are compelled to align their own concurrent syllable production with the perceived rate, whereas othe...

journal_title：Nature neuroscience

authors： Assaneo MF,Ripollés P,Orpella J,Lin WM,de Diego-Balaguer R,Poeppel D

更新日期：2019-04-01 00:00:00

abstract：:EphAs and ephrinAs are expressed in multiple areas of the developing brain in overlapping countergradients, notably in the retina and tectum. Here they are involved in targeting retinal axons to their correct topographic position in the tectum. We have used truncated versions of EphA3, single-amino acid point mutants ...

journal_title：Nature neuroscience

authors： Carvalho RF,Beutler M,Marler KJ,Knöll B,Becker-Barroso E,Heintzmann R,Ng T,Drescher U

更新日期：2006-03-01 00:00:00

abstract：:Binocular competition is thought to drive eye-specific segregation in the developing visual system, potentially through Hebbian synaptic learning rules that are sensitive to correlations in afferent activity. Altering retinal activity can disrupt eye-specific segregation, but little is known about the temporal feature...

journal_title：Nature neuroscience

authors： Zhang J,Ackman JB,Xu HP,Crair MC

更新日期：2011-11-18 00:00:00

abstract：:Synaptic strength can be altered by a variety of pre- or postsynaptic modifications. Here we test the hypothesis that long-term depression (LTD) involves a decrease in the number of glutamate receptors that are clustered at individual synapses in primary cultures of hippocampal neurons. Similar to a prominent form of ...

journal_title：Nature neuroscience

authors： Carroll RC,Lissin DV,von Zastrow M,Nicoll RA,Malenka RC

更新日期：1999-05-01 00:00:00

abstract：:The endocytosis of AMPA receptors (AMPARs) underlies several forms of synaptic plasticity, including NMDA receptor (NMDAR)-dependent long-term depression (LTD), but the molecular mechanisms responsible for this trafficking remain unknown. We found that PSD-95, a major postsynaptic density protein, is important for NMD...

journal_title：Nature neuroscience

authors： Bhattacharyya S,Biou V,Xu W,Schlüter O,Malenka RC

更新日期：2009-02-01 00:00:00

abstract：:Humans exhibit a remarkable degree of resilience in the face of extreme stress, with most resisting the development of neuropsychiatric disorders. Over the past 5 years, there has been increasing interest in the active, adaptive coping mechanisms of resilience; however, in humans, most published work focuses on correl...

journal_title：Nature neuroscience

authors： Russo SJ,Murrough JW,Han MH,Charney DS,Nestler EJ

更新日期：2012-11-01 00:00:00

abstract：:Here, we characterized behavioral abnormalities induced by prolonged social isolation in adult rodents. Social isolation induced both anxiety- and anhedonia-like symptoms and decreased cAMP response element-binding protein (CREB) activity in the nucleus accumbens shell (NAcSh). All of these abnormalities were reversed...

journal_title：Nature neuroscience

authors： Wallace DL,Han MH,Graham DL,Green TA,Vialou V,Iñiguez SD,Cao JL,Kirk A,Chakravarty S,Kumar A,Krishnan V,Neve RL,Cooper DC,Bolaños CA,Barrot M,McClung CA,Nestler EJ

更新日期：2009-02-01 00:00:00

abstract：:Dendritic spikes signal synaptic integration at remote apical dendritic sites in neocortical pyramidal neurons in vitro. Do dendritic spikes have a salient signaling role under in vivo conditions, where neocortical pyramidal neurons are bombarded with synaptic input? In the present study, levels of synaptic conductanc...

journal_title：Nature neuroscience

authors： Williams SR

更新日期：2004-09-01 00:00:00

abstract：:Although long-term potentiation (LTP) is long-lasting, it is not permanent and decays within weeks after its induction. Little is known about the processes underlying this decay. Here we assessed the contribution of synaptic activity to LTP decay by determining the effect of the competitive NMDA receptor antagonist CP...

journal_title：Nature neuroscience

authors： Villarreal DM,Do V,Haddad E,Derrick BE

更新日期：2002-01-01 00:00:00

abstract：:We used high-level configural aftereffects induced by adaptation to realistic faces to investigate visual representations underlying complex pattern perception. We found that exposure to an individual face for a few seconds generated a significant and precise bias in the subsequent perception of face identity. In the ...

journal_title：Nature neuroscience

authors： Leopold DA,O'Toole AJ,Vetter T,Blanz V

更新日期：2001-01-01 00:00:00

abstract：:In this Perspective, we expand the notion of temporal regulation of RNA in the brain and propose that the qualitative nature of RNA and its metabolism, together with RNA abundance, are essential for the molecular mechanisms underlying experience-dependent plasticity. We discuss emerging concepts in the newly burgeonin...

journal_title：Nature neuroscience

authors： Nainar S,Marshall PR,Tyler CR,Spitale RC,Bredy TW

更新日期：2016-09-27 00:00:00

abstract：:In the nose, odorants are detected on the cilia of olfactory sensory neurons (OSNs), where a cAMP-mediated signaling pathway transforms odor stimulation into electrical responses. Phosphodiesterase (PDE) activity in OSN cilia has long been thought to account for rapid response termination by degrading odor-induced cAM...

journal_title：Nature neuroscience

authors： Cygnar KD,Zhao H

更新日期：2009-04-01 00:00:00

abstract：:In neocortical circuits, repetitively active neurons evoke unitary postsynaptic potentials (PSPs) whose peak amplitudes either increase (facilitate) or decrease (depress) progressively. To examine the basis for these different synaptic responses, we made simultaneous recordings from three classes of neurons in cortica...

journal_title：Nature neuroscience

authors： Reyes A,Lujan R,Rozov A,Burnashev N,Somogyi P,Sakmann B

更新日期：1998-08-01 00:00:00

abstract：:Blood flow into the brain is dynamically regulated to satisfy the changing metabolic requirements of neurons, but how this is accomplished has remained unclear. Here we demonstrate a central role for capillary endothelial cells in sensing neural activity and communicating it to upstream arterioles in the form of an el...

journal_title：Nature neuroscience

authors： Longden TA,Dabertrand F,Koide M,Gonzales AL,Tykocki NR,Brayden JE,Hill-Eubanks D,Nelson MT

更新日期：2017-05-01 00:00:00

abstract：:Class I histone deacetylases (HDACs) Hdac1 and Hdac2 can associate together in protein complexes with transcriptional factors such as methyl-CpG-binding protein 2 (MeCP2). Given their high degree of sequence identity, we examined whether Hdac1 and Hdac2 were functionally redundant in mature mouse brain. We demonstrate...

journal_title：Nature neuroscience

authors： Mahgoub M,Adachi M,Suzuki K,Liu X,Kavalali ET,Chahrour MH,Monteggia LM

更新日期：2016-11-01 00:00:00

abstract：:Attention powerfully influences auditory perception, but little is understood about the mechanisms whereby attention sharpens responses to unattended sounds. We used high-resolution surface mapping techniques (using functional magnetic resonance imaging, fMRI) to examine activity in human auditory cortex during an int...

journal_title：Nature neuroscience

authors： Petkov CI,Kang X,Alho K,Bertrand O,Yund EW,Woods DL

更新日期：2004-06-01 00:00:00

abstract：:We studied how the posterior parietal cortex combines new information with ongoing activity dynamics as mice accumulate evidence during a virtual navigation task. Using new methods to analyze population activity on single trials, we found that activity transitioned rapidly between different sets of active neurons. Eac...

journal_title：Nature neuroscience

authors： Morcos AS,Harvey CD

更新日期：2016-12-01 00:00:00

abstract：:In the published version of this article, a data point is missing from Fig. 4f, and the y-axis label reads "RFpre"; it should read "RFpref." The original article has not been corrected. The original and corrected figures are shown in the accompanying Publisher Correction. ...

journal_title：Nature neuroscience

authors： Lien AD,Scanziani M

更新日期：2018-09-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is genetically heterogeneous with convergent symptomatology, suggesting common dysregulated pathways. In this study, we analyzed brain transcriptional changes in five mouse models of Pitt-Hopkins syndrome (PTHS), a syndromic form of ASD caused by mutations in the TCF4 gene, but not the T...

journal_title：Nature neuroscience

authors： Phan BN,Bohlen JF,Davis BA,Ye Z,Chen HY,Mayfield B,Sripathy SR,Cerceo Page S,Campbell MN,Smith HL,Gallop D,Kim H,Thaxton CL,Simon JM,Burke EE,Shin JH,Kennedy AJ,Sweatt JD,Philpot BD,Jaffe AE,Maher BJ

更新日期：2020-03-01 00:00:00

abstract：:Communication between glia cells and neurons is crucial for brain functions, but the molecular mechanisms and functional consequences of gliotransmission remain enigmatic. Here we report that astrocytes express synaptobrevin II and cellubrevin as functionally non-overlapping vesicular SNARE proteins on glutamatergic v...

journal_title：Nature neuroscience

authors： Schwarz Y,Zhao N,Kirchhoff F,Bruns D

更新日期：2017-11-01 00:00:00

abstract：:Speech and vocal impairments characterize many neurological disorders. However, the neurogenetic mechanisms of these disorders are not well understood, and current animal models do not have the necessary circuitry to recapitulate vocal learning deficits. We developed germline transgenic songbirds, zebra finches (Tanei...

journal_title：Nature neuroscience

authors： Liu WC,Kohn J,Szwed SK,Pariser E,Sepe S,Haripal B,Oshimori N,Marsala M,Miyanohara A,Lee R

更新日期：2015-11-01 00:00:00

abstract：:The olfactory system faces a hard problem: on the basis of noisy information from olfactory receptor neurons (the neurons that transduce chemicals to neural activity), it must figure out which odors are present in the world. Odors almost never occur in isolation, and different odors excite overlapping populations of o...

journal_title：Nature neuroscience

authors： Grabska-Barwińska A,Barthelmé S,Beck J,Mainen ZF,Pouget A,Latham PE

更新日期：2017-01-01 00:00:00

abstract：:Sensory neural systems use spatiotemporal coding mechanisms to represent stimuli. These time-varying response patterns sometimes outlast the stimulus. Can the temporal structure of a stimulus interfere with, or even disrupt, the spatiotemporal structure of the neural representation? We investigated this potential conf...

journal_title：Nature neuroscience

authors： Brown SL,Joseph J,Stopfer M

更新日期：2005-11-01 00:00:00

abstract：:In mammals, many daily cycles are driven by a central circadian clock, which is based on the cell-autonomous rhythmic expression of clock genes. It is not clear, however, how peripheral cells are able to interpret the rhythmic signals disseminated from this central oscillator. Here we show that cycling expression of t...

journal_title：Nature neuroscience

authors： von Gall C,Garabette ML,Kell CA,Frenzel S,Dehghani F,Schumm-Draeger PM,Weaver DR,Korf HW,Hastings MH,Stehle JH

更新日期：2002-03-01 00:00:00

abstract：:Neocortical GABAergic neurons have diverse molecular, structural and electrophysiological features, but the functional correlates of this diversity are largely unknown. We found unique membrane potential dynamics of somatostatin-expressing (SOM) neurons in layer 2/3 of the primary somatosensory barrel cortex of awake ...

journal_title：Nature neuroscience

authors： Gentet LJ,Kremer Y,Taniguchi H,Huang ZJ,Staiger JF,Petersen CC

更新日期：2012-02-26 00:00:00

abstract：:Cue-triggered recall of learned temporal sequences is an important cognitive function that has been attributed to higher brain areas. Here recordings in both anesthetized and awake rats demonstrate that after repeated stimulation with a moving spot that evoked sequential firing of an ensemble of primary visual cortex ...

journal_title：Nature neuroscience

authors： Xu S,Jiang W,Poo MM,Dan Y

更新日期：2012-01-22 00:00:00