Abstract：
:Dopamine signaling is implicated in reinforcement learning, but the neural substrates targeted by dopamine are poorly understood. We bypassed dopamine signaling itself and tested how optogenetic activation of dopamine D1 or D2 receptor–expressing striatal projection neurons influenced reinforcement learning in mice. Stimulating D1 receptor–expressing neurons induced persistent reinforcement, whereas stimulating D2 receptor–expressing neurons induced transient punishment, indicating that activation of these circuits is sufficient to modify the probability of performing future actions.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Kravitz AV,Tye LD,Kreitzer ACdoi
10.1038/nn.3100subject
Has Abstractpub_date
2012-06-01 00:00:00pages
816-8issue
6eissn
1097-6256issn
1546-1726pii
nn.3100journal_volume
15pub_type
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