Abstract:
:Neurobiological theories of knowledge processing are biased toward the language-dominant (usually the left) hemisphere. Does the right hemisphere critically contribute to knowledge processing? J.A. is a left-hemisphere language-dominant individual who suffered a lesion confined to the right mid- and anterior fusiform gyrus. Although her language abilities are intact, she showed a partial loss of knowledge of the visual attributes of biological and nonbiological entities. This was observed regardless of the task performed: object discrimination, oral feature generation, forced-choice naming-to-definition or free-hand drawing. Functional-associative and nonvisual sensory attributes were spared. The same region that was lesioned in J.A. was activated in a functional magnetic resonance imaging study in 27 volunteers who retrieved semantic associations between concepts, but only if the concepts were represented as pictures and not as words. Therefore, right fusiform gyrus critically contributes to the conscious recollection of visual attributes of familiar entities.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Vandenbulcke M,Peeters R,Fannes K,Vandenberghe Rdoi
10.1038/nn1721subject
Has Abstractpub_date
2006-07-01 00:00:00pages
964-70issue
7eissn
1097-6256issn
1546-1726pii
nn1721journal_volume
9pub_type
杂志文章abstract::The balance between proliferation and apoptosis is critical for proper development of the nervous system. Yet, little is known about molecules that regulate apoptosis of proliferative neurons. Here we identify a soluble, secreted form of CPG15 expressed in embryonic rat brain regions undergoing rapid proliferation and...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1407
更新日期:2005-03-01 00:00:00
abstract::The painful sensations produced by a laceration, freeze, burn, muscle strain or internal injury are readily distinguishable because each is characterized by a particular sensory quality such as sharp, aching, burning or prickling. We propose that there are specific neural correlates of each pain quality, and here we u...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn955
更新日期:2002-11-01 00:00:00
abstract::The majority of neurons in primary visual cortex are tuned for stimulus orientation, but the factors that account for the range of orientation selectivities exhibited by cortical neurons remain unclear. To address this issue, we used in vivo two-photon calcium imaging to characterize the orientation tuning and spatial...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4323
更新日期:2016-08-01 00:00:00
abstract::The shift in ocular dominance induced by brief monocular deprivation is greatest during a postnatal critical period and is thought to decline irreversibly thereafter. However, here we demonstrate that complete visual deprivation through dark exposure restores rapid ocular dominance plasticity in adult rats. In additio...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1965
更新日期:2007-09-01 00:00:00
abstract::To investigate the mechanisms of persistent neural activity, we obtained in vivo intracellular recordings from neurons in an oculomotor neural integrator of the goldfish during spontaneous saccades and fixations. Persistent changes in firing rate following saccades were associated with step changes in interspike membr...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/84023
更新日期:2001-02-01 00:00:00
abstract::Although the prefrontal cortex influences motivated behavior, its role in food intake remains unclear. Here, we demonstrate a role for D1-type dopamine receptor-expressing neurons in the medial prefrontal cortex (mPFC) in the regulation of feeding. Food intake increases activity in D1 neurons of the mPFC in mice, and ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3625
更新日期:2014-02-01 00:00:00
abstract::A central neuroscientific pursuit is understanding neuronal interactions that support computations underlying cognition and behavior. Although neurons interact across disparate scales, from cortical columns to whole-brain networks, research has been restricted to one scale at a time. We measured local interactions thr...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3979
更新日期:2015-05-01 00:00:00
abstract::Vesicular release of neurotransmitter is the universal output signal of neurons in the brain. It is generally believed that fast transmitter release is restricted to nerve terminals that contact postsynaptic cells in the gray matter. Here we show in the rat brain that the neurotransmitter glutamate is also released at...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1850
更新日期:2007-03-01 00:00:00
abstract::Individuals' risk attitudes are known to guide choices about uncertain options. However, in the presence of others' decisions, these choices can be swayed and manifest as riskier or safer behavior than one would express alone. To test the mechanisms underlying effective social 'nudges' in human decision-making, we use...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4022
更新日期:2015-06-01 00:00:00
abstract::The mammalian visual system contains an extensive web of feedback connections projecting from higher cortical areas to lower areas, including primary visual cortex. Although multiple theories have been proposed, the role of these connections in perceptual processing is not understood. We found that the pattern of func...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2218
更新日期:2008-12-01 00:00:00
abstract::Ample evidence suggests that primary visual cortex is involved in the perception of form, and there is increasing evidence that it may also be important in the perception of surfaces. Perceptual qualities of surfaces, such as brightness, are based on extensive integration of information throughout the visual field. In...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/2849
更新日期:1998-11-01 00:00:00
abstract::Orchestrating appropriate behavioral responses in the face of competing signals that predict either rewards or threats in the environment is crucial for survival. The basolateral nucleus of the amygdala (BLA) and prelimbic (PL) medial prefrontal cortex have been implicated in reward-seeking and fear-related responses,...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4553
更新日期:2017-06-01 00:00:00
abstract::In vivo model systems are a critical tool for gaining insight into the pathology underlying psychiatric disorders. Although modern functional imaging tools allow study of brain correlates of behavior in clinical groups and genome-wide association studies are beginning to uncover the complex genetic architecture of psy...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.4413
更新日期:2016-11-01 00:00:00
abstract::Understanding the origins and evolution of synapses may provide insight into species diversity and the organization of the brain. Using comparative proteomics and genomics, we examined the evolution of the postsynaptic density (PSD) and membrane-associated guanylate kinase (MAGUK)-associated signaling complexes (MASCs...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2135
更新日期:2008-07-01 00:00:00
abstract::The regulation of female reproductive behaviors may involve memories of male pheromone signatures, formed in part by neural circuitry involving the olfactory bulb and hippocampus. These neural structures are the principal sites of adult neurogenesis; however, previous studies point to their independent regulation by s...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1928
更新日期:2007-08-01 00:00:00
abstract::Many types of neurons can release endocannabinoids that act as retrograde signals to inhibit neurotransmitter release from presynaptic terminals. Little is known, however, about the properties or role of such inhibition under physiological conditions. Here we report that brief bursts of presynaptic activity evoked end...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1126
更新日期:2003-10-01 00:00:00
abstract::Sensory pathways are typically studied by starting at receptor neurons and following postsynaptic neurons into the brain. However, this leads to a bias in analyses of activity toward the earliest layers of processing. Here, we present new methods for volumetric neural imaging with precise across-brain registration to ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-020-00743-y
更新日期:2021-01-01 00:00:00
abstract::Phagocytic cell NADPH oxidase (NOX) generates reactive oxygen species (ROS) as part of innate immunity. Unfortunately, ischemia can also induce this pathway and inflict damage on native cells. The voltage-gated proton channel Hv1 enables NOX function by compensating cellular loss of electrons with protons. Accordingly...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3059
更新日期:2012-03-04 00:00:00
abstract::Using multimodal neuroimaging in humans, we demonstrate specific interactions between prefrontal activity and midbrain dopaminergic synthesis. A common V(108/158)M substitution in the gene for catecholamine-O-methyltransferase (COMT), an important enzyme regulating prefrontal dopamine turnover, predicted reduced dopam...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1438
更新日期:2005-05-01 00:00:00
abstract::Continuous, predictable events and spontaneous events may coincide in the visual environment. For a continuously moving object, the brain compensates for delays in transmission between a retinal event and neural responses in higher visual areas. Here we show that it similarly compensated for other smoothly changing fe...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/74865
更新日期:2000-05-01 00:00:00
abstract::The projections and odor responses of mammalian olfactory receptor neurons, as well as the physiology of the bulb's principal neurons-the mitral cells (MCs)-are known from studies in slices and anesthetized animals. In behaving rats trained to discriminate between two odors associated with different reinforcers, we ex...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/14801
更新日期:1999-11-01 00:00:00
abstract::Modeling of human neuropsychiatric disorders in animals is extremely challenging given the subjective nature of many symptoms, the lack of biomarkers and objective diagnostic tests, and the early state of the relevant neurobiology and genetics. Nonetheless, progress in understanding pathophysiology and in treatment de...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.2647
更新日期:2010-10-01 00:00:00
abstract::Increases in dopamine and glutamate transmission in the nucleus accumbens independently promote the reinstatement of cocaine seeking, an animal model of relapse. Here we have tested whether cocaine reinstatement in rats depends on interactions between accumbal dopamine and glutamate systems that are mediated by Ca(2+)...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn2054
更新日期:2008-03-01 00:00:00
abstract::A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and brain damage. Despite the involvement of distinct proteins in different NDs, the process of protein misfolding and aggregation is remarka...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/s41593-018-0235-9
更新日期:2018-10-01 00:00:00
abstract::In the nose, odorants are detected on the cilia of olfactory sensory neurons (OSNs), where a cAMP-mediated signaling pathway transforms odor stimulation into electrical responses. Phosphodiesterase (PDE) activity in OSN cilia has long been thought to account for rapid response termination by degrading odor-induced cAM...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2289
更新日期:2009-04-01 00:00:00
abstract::In this report we describe how common brain networks within the medial frontal cortex (MFC) facilitate adaptive behavioral control in rodents and humans. We demonstrate that after errors, low-frequency oscillations below 12 Hz are modulated over the midfrontal cortex in humans and within the prelimbic and anterior cin...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3549
更新日期:2013-12-01 00:00:00
abstract::In the cat primary visual cortex, neurons are classified into the two main categories of simple cells and complex cells based on their response properties. According to the hierarchical model, complex receptive fields derive from convergent inputs of simple cells with similar orientation preferences. This model receiv...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/1609
更新日期:1998-09-01 00:00:00
abstract::Cannabis is the most frequently used illicit psychoactive substance worldwide; around one in ten users become dependent. The risk for cannabis use disorder (CUD) has a strong genetic component, with twin heritability estimates ranging from 51 to 70%. Here we performed a genome-wide association study of CUD in 2,387 ca...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0416-1
更新日期:2019-07-01 00:00:00
abstract::The autosomal dominant disorder neurofibromatosis type 2 (NF2) is a hereditary tumor syndrome caused by inactivation of the NF2 tumor suppressor gene, encoding merlin. Apart from tumors affecting the peripheral and central nervous systems, most NF2 patients develop peripheral neuropathies. This peripheral nerve diseas...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3348
更新日期:2013-04-01 00:00:00
abstract::Successfully navigating in physical or semantic space requires a neural representation of allocentric (map-based) vectors to boundaries, objects and goals. Cognitive processes such as path-planning and imagination entail the recall of vector representations, but evidence of neuron-level memory for allocentric vectors ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-020-00761-w
更新日期:2020-12-21 00:00:00