Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording study.

abstract：:Here we used magnetoencephalography (MEG) to investigate stages of processing in face perception in humans. We found a face-selective MEG response occurring only 100 ms after stimulus onset (the 'M100'), 70 ms earlier than previously reported. Further, the amplitude of this M100 response was correlated with successful...

journal_title：Nature neuroscience

authors： Liu J,Harris A,Kanwisher N

更新日期：2002-09-01 00:00:00

abstract：:To investigate the mechanisms of persistent neural activity, we obtained in vivo intracellular recordings from neurons in an oculomotor neural integrator of the goldfish during spontaneous saccades and fixations. Persistent changes in firing rate following saccades were associated with step changes in interspike membr...

journal_title：Nature neuroscience

authors： Aksay E,Gamkrelidze G,Seung HS,Baker R,Tank DW

更新日期：2001-02-01 00:00:00

abstract：:The hindbrain transcription factors Phox2b and Egr2 (also known as Krox20) are linked to the development of the autonomic nervous system and rhombomere-related regulation of breathing, respectively. Mutations in these proteins can lead to abnormal breathing behavior as a result of an alteration in an unidentified neur...

journal_title：Nature neuroscience

authors： Thoby-Brisson M,Karlén M,Wu N,Charnay P,Champagnat J,Fortin G

更新日期：2009-08-01 00:00:00

abstract：:Mammalian hearing owes its remarkable sensitivity and frequency selectivity to a local mechanical feedback process within the cochlea. Cochlear outer hair cells (OHCs) function as the key elements in the feedback loop in which the fast somatic motility of OHCs is thought to be the source of cochlear amplification. An ...

journal_title：Nature neuroscience

authors： Jia S,He DZ

更新日期：2005-08-01 00:00:00

abstract：:The classic 'size principle' of motor control describes how increasingly forceful movements arise by the recruitment of motoneurons of progressively larger size and force output into the active pool. We explored the activity of pools of spinal interneurons in larval zebrafish and found that increases in swimming speed...

journal_title：Nature neuroscience

authors： McLean DL,Masino MA,Koh IY,Lindquist WB,Fetcho JR

更新日期：2008-12-01 00:00:00

abstract：:It is unclear how knowledge of one's actions and one's body contribute to the understanding of others' actions. Here we show that two subjects lacking cutaneous touch and sense of movement and position show a selective deficit in interpreting another person's anticipation of weight when seeing him lifting boxes. We su...

journal_title：Nature neuroscience

authors： Bosbach S,Cole J,Prinz W,Knoblich G

更新日期：2005-10-01 00:00:00

abstract：:Uncovering structural regularities and architectural topologies of cortical circuitry is vital for understanding neural computations. Recently, an experimentally constrained algorithm generated a dense network reconstruction of a ∼0.3-mm3 volume from juvenile rat somatosensory neocortex, comprising ∼31,000 cells and ∼...

journal_title：Nature neuroscience

authors： Gal E,London M,Globerson A,Ramaswamy S,Reimann MW,Muller E,Markram H,Segev I

更新日期：2017-07-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature neuroscience

authors： Mongillo G,Rumpel S,Loewenstein Y

更新日期：2019-12-01 00:00:00

abstract：:Over the past two centuries, prevalent models of energy and glucose homeostasis have emerged from careful anatomical descriptions in tandem with an understanding of cellular physiology. More recent technological advances have culminated in the identification of peripheral and central factors that influence neural circ...

journal_title：Nature neuroscience

authors： Williams KW,Elmquist JK

更新日期：2012-10-01 00:00:00

abstract：:We used high-level configural aftereffects induced by adaptation to realistic faces to investigate visual representations underlying complex pattern perception. We found that exposure to an individual face for a few seconds generated a significant and precise bias in the subsequent perception of face identity. In the ...

journal_title：Nature neuroscience

authors： Leopold DA,O'Toole AJ,Vetter T,Blanz V

更新日期：2001-01-01 00:00:00

abstract：:We studied the febrile response in mice deficient in microsomal prostaglandin E synthase-1 (mPGES-1), an inducible terminal isomerase expressed in cytokine-sensitive brain endothelial cells. These animals showed no fever and no central prostaglandin (PG) E2 synthesis after peripheral injection of bacterial-wall lipopo...

journal_title：Nature neuroscience

authors： Engblom D,Saha S,Engström L,Westman M,Audoly LP,Jakobsson PJ,Blomqvist A

更新日期：2003-11-01 00:00:00

abstract：:Hippocampal CA1 pyramidal neurons have frequently been regarded as a homogeneous cell population in biophysical, pharmacological and modeling studies. We found robust differences between pyramidal neurons residing in the deep and superficial CA1 sublayers in rats. Compared with their superficial peers, deep pyramidal ...

journal_title：Nature neuroscience

authors： Mizuseki K,Diba K,Pastalkova E,Buzsáki G

更新日期：2011-08-07 00:00:00

abstract：:Aggression is a social behavior essential for securing resources and defending oneself and family. Thanks to its indispensable function in competition and thus survival, aggression exists widely across animal species, including humans. Classical works from Tinbergen and Lorenz concluded that instinctive behaviors incl...

journal_title：Nature neuroscience

authors： Lischinsky JE,Lin D

更新日期：2020-11-01 00:00:00

abstract：:Most neurons in macaque area MT are selective for the direction of stimulus motion. By comparing direction selectivity for gratings and plaids, we classified MT neurons as pattern direction selective (PDS) or component direction selective (CDS). We compared the time course of responses in CDS and PDS neurons in opiate...

journal_title：Nature neuroscience

authors： Smith MA,Majaj NJ,Movshon JA

更新日期：2005-02-01 00:00:00

abstract：:Very little is known about how stimuli that are typically not rich in sugars, such as beer, trigger attractive gustatory responses in Drosophila. We identified a member of the gustatory receptor family, Gr64e, as a receptor that is required for feeding preference for beer and other sources that have fermenting yeast. ...

journal_title：Nature neuroscience

authors： Wisotsky Z,Medina A,Freeman E,Dahanukar A

更新日期：2011-11-06 00:00:00

abstract：:The zona limitans intrathalamica (ZLI), a narrow compartment in the vertebrate forebrain that bisects the diencephalon transversely, expresses the secreted factor sonic hedgehog (Shh). Because genetic disruption of Shh in mouse causes severe early developmental defects, this strategy has not been useful in identifying...

journal_title：Nature neuroscience

authors： Kiecker C,Lumsden A

更新日期：2004-11-01 00:00:00

abstract：:Polyamines are endogenous molecules involved in cell damage following neurological insults, although it is unclear whether polyamines reduce or exacerbate this damage. We used a developmental seizure model in which we exposed Xenopus laevis tadpoles to pentylenetetrazole (PTZ), a known convulsant. We found that, after...

journal_title：Nature neuroscience

authors： Bell MR,Belarde JA,Johnson HF,Aizenman CD

更新日期：2011-04-01 00:00:00

abstract：:The hippocampus is thought to be involved in episodic memory formation by reactivating traces of waking experience during sleep. Indeed, the joint firing of spatially tuned pyramidal cells encoding nearby places recur during sleep. We found that the sleep cofiring of rat CA1 pyramidal cells encoding similar places inc...

journal_title：Nature neuroscience

authors： O'Neill J,Senior TJ,Allen K,Huxter JR,Csicsvari J

更新日期：2008-02-01 00:00:00

abstract：:Synaptic vesicles release neurotransmitter both actively (on stimulation) and spontaneously (at rest). It has been assumed that identical vesicles use both modes of release; however, recent evidence has challenged this view. Using several assays (FM dye imaging, pHluorin imaging and antibody-labeling of synaptotagmin)...

journal_title：Nature neuroscience

authors： Wilhelm BG,Groemer TW,Rizzoli SO

更新日期：2010-12-01 00:00:00

abstract：:Binocular competition is thought to drive eye-specific segregation in the developing visual system, potentially through Hebbian synaptic learning rules that are sensitive to correlations in afferent activity. Altering retinal activity can disrupt eye-specific segregation, but little is known about the temporal feature...

journal_title：Nature neuroscience

authors： Zhang J,Ackman JB,Xu HP,Crair MC

更新日期：2011-11-18 00:00:00

abstract：:Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood. Here we investigated the neuronal pathways for itch neurotransmission, particularly the contribution of the neuropeptide ...

journal_title：Nature neuroscience

authors： Huang J,Polgár E,Solinski HJ,Mishra SK,Tseng PY,Iwagaki N,Boyle KA,Dickie AC,Kriegbaum MC,Wildner H,Zeilhofer HU,Watanabe M,Riddell JS,Todd AJ,Hoon MA

更新日期：2018-05-01 00:00:00

abstract：:Most advances in addiction treatment to date have addressed the physical dependence and withdrawal that accompany addiction to some drugs of abuse. In contrast, it has proven more difficult to develop medications that effectively treat drug craving and relapse, the core features of addictive disorders. Current efforts...

journal_title：Nature neuroscience

authors： Nestler EJ

更新日期：2002-11-01 00:00:00

abstract：:A brief visual target stimulus may be rendered invisible if it is immediately preceded or followed by another stimulus. This class of illusions, known as visual masking, may allow insights into the neural mechanisms that underlie visual perception. We have therefore explored the temporal characteristics of masking ill...

journal_title：Nature neuroscience

authors： Macknik SL,Livingstone MS

更新日期：1998-06-01 00:00:00

abstract：:Many neural signaling receptors are regulated by endocytosis, but little is known about receptor insertion into the plasma membrane. Time-lapse imaging of the beta2 adrenergic receptor expressed in cultured rat hippocampal neurons, using pH-sensitive green fluorescent protein tagging and total internal reflection fluo...

journal_title：Nature neuroscience

authors： Yudowski GA,Puthenveedu MA,von Zastrow M

更新日期：2006-05-01 00:00:00

abstract：:Information analysis shows that face-selective neurons in inferior temporal cortex encode different stimulus attributes early and late in their response to the same image. ...

journal_title：Nature neuroscience

authors： Oram MW,Richmond BJ

更新日期：1999-10-01 00:00:00

abstract：:The molecular mechanisms that activate morphogenesis of cerebral cortex are currently the subject of intensive experimental analysis. Transcription factor genes of the homeobox, basic helix-loop-helix (bHLH) and zinc-finger families have recently been shown to have essential roles in this process. However, the actual ...

journal_title：Nature neuroscience

authors： Muzio L,Di Benedetto B,Stoykova A,Boncinelli E,Gruss P,Mallamaci A

更新日期：2002-08-01 00:00:00

abstract：:How tightly tuned are the synaptic and intrinsic properties that give rise to neuron and circuit function? Experimental work shows that these properties vary considerably across identified neurons in different animals. Given this variability in experimental data, this review describes some of the complications of buil...

journal_title：Nature neuroscience

authors： Marder E,Taylor AL

更新日期：2011-02-01 00:00:00

abstract：:Motion and stereoscopic depth are fundamental parameters of the structural analysis of visual scenes. Because they are defined by a difference in object position, either over time or across the eyes, a common neural machinery may be used for encoding these attributes. To examine this idea, we analyzed responses of bin...

journal_title：Nature neuroscience

authors： Anzai A,Ohzawa I,Freeman RD

更新日期：2001-05-01 00:00:00

abstract：:The growth of neurites (axon and dendrite) should be appropriately regulated by their interactions in the development of nervous systems where a myriad of neurons and their neurites are tightly packed. We show here that mammalian seven-pass transmembrane cadherins Celsr2 and Celsr3 are activated by their homophilic in...

journal_title：Nature neuroscience

authors： Shima Y,Kawaguchi SY,Kosaka K,Nakayama M,Hoshino M,Nabeshima Y,Hirano T,Uemura T

更新日期：2007-08-01 00:00:00

abstract：:The deposition of aggregated amyloid-β peptides derived from the pro-amyloidogenic processing of the amyloid precurson protein (APP) into characteristic amyloid plaques (APs) is distinctive to Alzheimer's disease (AD). Alternative APP processing via the metalloprotease ADAM10 prevents amyloid-β formation. We tested wh...

journal_title：Nature neuroscience

authors： Esteve P,Rueda-Carrasco J,Inés Mateo M,Martin-Bermejo MJ,Draffin J,Pereyra G,Sandonís Á,Crespo I,Moreno I,Aso E,Garcia-Esparcia P,Gomez-Tortosa E,Rábano A,Fortea J,Alcolea D,Lleo A,Heneka MT,Valpuesta JM,Esteban JA,

更新日期：2019-08-01 00:00:00