Abstract:
:We studied the febrile response in mice deficient in microsomal prostaglandin E synthase-1 (mPGES-1), an inducible terminal isomerase expressed in cytokine-sensitive brain endothelial cells. These animals showed no fever and no central prostaglandin (PG) E2 synthesis after peripheral injection of bacterial-wall lipopolysaccharide, but their pyretic capacity in response to centrally administered PGE2 was intact. Our findings identify mPGES-1 as the central switch during immune-induced pyresis and as a target for the treatment of fever and other PGE2-dependent acute phase reactions elicited by the brain.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Engblom D,Saha S,Engström L,Westman M,Audoly LP,Jakobsson PJ,Blomqvist Adoi
10.1038/nn1137subject
Has Abstractpub_date
2003-11-01 00:00:00pages
1137-8issue
11eissn
1097-6256issn
1546-1726pii
nn1137journal_volume
6pub_type
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