Abstract:
:Uncovering structural regularities and architectural topologies of cortical circuitry is vital for understanding neural computations. Recently, an experimentally constrained algorithm generated a dense network reconstruction of a ∼0.3-mm3 volume from juvenile rat somatosensory neocortex, comprising ∼31,000 cells and ∼36 million synapses. Using this reconstruction, we found a small-world topology with an average of 2.5 synapses separating any two cells and multiple cell-type-specific wiring features. Amounts of excitatory and inhibitory innervations varied across cells, yet pyramidal neurons maintained relatively constant excitation/inhibition ratios. The circuit contained highly connected hub neurons belonging to a small subset of cell types and forming an interconnected cell-type-specific rich club. Certain three-neuron motifs were overrepresented, matching recent experimental results. Cell-type-specific network properties were even more striking when synaptic strength and sign were considered in generating a functional topology. Our systematic approach enables interpretation of microconnectomics 'big data' and provides several experimentally testable predictions.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Gal E,London M,Globerson A,Ramaswamy S,Reimann MW,Muller E,Markram H,Segev Idoi
10.1038/nn.4576subject
Has Abstractpub_date
2017-07-01 00:00:00pages
1004-1013issue
7eissn
1097-6256issn
1546-1726pii
nn.4576journal_volume
20pub_type
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