Stages of processing in face perception: an MEG study.

abstract：:Voltage-gated sodium channels (Na(V)) are critical for initiation of action potentials. Heterozygous loss-of-function mutations in Na(V)1.1 channels cause severe myoclonic epilepsy in infancy (SMEI). Homozygous null Scn1a-/- mice developed ataxia and died on postnatal day (P) 15 but could be sustained to P17.5 with ma...

journal_title：Nature neuroscience

authors： Yu FH,Mantegazza M,Westenbroek RE,Robbins CA,Kalume F,Burton KA,Spain WJ,McKnight GS,Scheuer T,Catterall WA

更新日期：2006-09-01 00:00:00

abstract：:Sensorimotor integration is crucial to perception and motor control. How and where this process takes place in the brain is still largely unknown. Here we analyze the cerebellar contribution to sensorimotor integration in the whisker system of mice. We identify an area in the cerebellum where cortical sensory and moto...

journal_title：Nature neuroscience

authors： Proville RD,Spolidoro M,Guyon N,Dugué GP,Selimi F,Isope P,Popa D,Léna C

更新日期：2014-09-01 00:00:00

abstract：:In the cat primary visual cortex, neurons are classified into the two main categories of simple cells and complex cells based on their response properties. According to the hierarchical model, complex receptive fields derive from convergent inputs of simple cells with similar orientation preferences. This model receiv...

journal_title：Nature neuroscience

authors： Alonso JM,Martinez LM

更新日期：1998-09-01 00:00:00

abstract：:Neural progenitor cells in the developing neocortex change over time to produce different neurons, a phenomenon that is also observed in other regions of the nervous system. Mouse Numb (also known as m-numb) and Numbl (also known as numblike or Nbl) are redundant but essential in maintaining virtually all progenitor c...

journal_title：Nature neuroscience

authors： Petersen PH,Zou K,Krauss S,Zhong W

更新日期：2004-08-01 00:00:00

abstract：:During development, the mammalian ventral telencephalon is comprised of three major proliferative zones: the medial (MGE), lateral (LGE) and caudal (CGE) ganglionic eminences. Through gene expression studies, in vitro migration assays, genetic mutant analysis and in vivo fate mapping in mice, we found that the CGE is ...

journal_title：Nature neuroscience

authors： Nery S,Fishell G,Corbin JG

更新日期：2002-12-01 00:00:00

abstract：:It is unclear how knowledge of one's actions and one's body contribute to the understanding of others' actions. Here we show that two subjects lacking cutaneous touch and sense of movement and position show a selective deficit in interpreting another person's anticipation of weight when seeing him lifting boxes. We su...

journal_title：Nature neuroscience

authors： Bosbach S,Cole J,Prinz W,Knoblich G

更新日期：2005-10-01 00:00:00

abstract：:The olfactory system faces a hard problem: on the basis of noisy information from olfactory receptor neurons (the neurons that transduce chemicals to neural activity), it must figure out which odors are present in the world. Odors almost never occur in isolation, and different odors excite overlapping populations of o...

journal_title：Nature neuroscience

authors： Grabska-Barwińska A,Barthelmé S,Beck J,Mainen ZF,Pouget A,Latham PE

更新日期：2017-01-01 00:00:00

abstract：:Axonal degeneration is important during development but has not been thought to function in the intact mature nervous system. Here, we provide evidence that degeneration of adult axons occurs in the intact rodent brain through a p75 neurotrophin receptor (p75NTR)- and myelin-dependent mechanism. Specifically, we show ...

journal_title：Nature neuroscience

authors： Park KJ,Grosso CA,Aubert I,Kaplan DR,Miller FD

更新日期：2010-05-01 00:00:00

abstract：:We used fluorescent in-situ hybridization and confocal microscopy to monitor the subcellular distribution of the immediate-early gene Arc. Arc RNA appeared in discrete intranuclear foci within minutes of neuronal activation and subsequently disappeared from the nucleus and accumulated in the cytoplasm by 30 minutes. T...

journal_title：Nature neuroscience

authors： Guzowski JF,McNaughton BL,Barnes CA,Worley PF

更新日期：1999-12-01 00:00:00

abstract：:Recent evidence suggests that presynaptic-acting NMDA receptors (preNMDARs) are important for neocortical synaptic transmission and plasticity. We found that unique properties of the NR3A subunit enable preNMDARs to enhance spontaneous and evoked glutamate release and that NR3A is required for spike timing-dependent l...

journal_title：Nature neuroscience

authors： Larsen RS,Corlew RJ,Henson MA,Roberts AC,Mishina M,Watanabe M,Lipton SA,Nakanishi N,Pérez-Otaño I,Weinberg RJ,Philpot BD

更新日期：2011-03-01 00:00:00

abstract：:The precise role of synchronous neuronal firing in signal encoding remains unclear. To examine what kinds of signals can be carried by synchrony, I reproduced a multilayer feedforward network of neurons in an in vitro slice preparation of rat cortex using an iterative procedure. When constant and time-varying frequenc...

journal_title：Nature neuroscience

authors： Reyes AD

更新日期：2003-06-01 00:00:00

abstract：:In mammals, many daily cycles are driven by a central circadian clock, which is based on the cell-autonomous rhythmic expression of clock genes. It is not clear, however, how peripheral cells are able to interpret the rhythmic signals disseminated from this central oscillator. Here we show that cycling expression of t...

journal_title：Nature neuroscience

authors： von Gall C,Garabette ML,Kell CA,Frenzel S,Dehghani F,Schumm-Draeger PM,Weaver DR,Korf HW,Hastings MH,Stehle JH

更新日期：2002-03-01 00:00:00

abstract：:To investigate synaptic events underlying sensory perception, we made whole-cell membrane potential recordings of barrel cortex neurons in awake mice while recording whisker-related behavior. During quiet periods, we recorded slow, large-amplitude membrane potential changes, which switched during whisking to small, fa...

journal_title：Nature neuroscience

authors： Crochet S,Petersen CC

更新日期：2006-05-01 00:00:00

abstract：:In vivo model systems are a critical tool for gaining insight into the pathology underlying psychiatric disorders. Although modern functional imaging tools allow study of brain correlates of behavior in clinical groups and genome-wide association studies are beginning to uncover the complex genetic architecture of psy...

journal_title：Nature neuroscience

authors： Averbeck BB,Chafee MV

更新日期：2016-11-01 00:00:00

abstract：:The structure and function of presynaptic and postsynaptic compartments varies markedly in neurons, but little is known about how they are functionally arranged with respect to each other. In rat hippocampal neurons, we found that, although they are structurally correlated from the early moments of formation, synapses...

journal_title：Nature neuroscience

authors： Kay L,Humphreys L,Eickholt BJ,Burrone J

更新日期：2011-06-01 00:00:00

abstract：:Projection neurons migrate from the ventricular zone to the neocortical plate during the development of the mouse brain. Their overall movement is radial, but they become multipolar and move nonradially in the intermediate zone. Here we show that Reelin, the Rap1 GTPase and N-cadherin (NCad) are important for multipol...

journal_title：Nature neuroscience

authors： Jossin Y,Cooper JA

更新日期：2011-06-01 00:00:00

abstract：:We studied the febrile response in mice deficient in microsomal prostaglandin E synthase-1 (mPGES-1), an inducible terminal isomerase expressed in cytokine-sensitive brain endothelial cells. These animals showed no fever and no central prostaglandin (PG) E2 synthesis after peripheral injection of bacterial-wall lipopo...

journal_title：Nature neuroscience

authors： Engblom D,Saha S,Engström L,Westman M,Audoly LP,Jakobsson PJ,Blomqvist A

更新日期：2003-11-01 00:00:00

abstract：:Much of the information processing in the brain occurs at the level of local circuits; however, the mechanisms underlying their initial development are poorly understood. We sought to examine the early development and plasticity of local excitatory circuits in the optic tectum of Xenopus laevis tadpoles. We found that...

journal_title：Nature neuroscience

authors： Pratt KG,Dong W,Aizenman CD

更新日期：2008-04-01 00:00:00

abstract：:Experience-dependent plasticity in adult visual cortex is believed to have important roles in visual coding and perceptual learning. Here we show that repeated stimulation with movies of natural scenes induces a rapid improvement in response reliability in cat visual cortex, whereas stimulation with white noise or fla...

journal_title：Nature neuroscience

authors： Yao H,Shi L,Han F,Gao H,Dan Y

更新日期：2007-06-01 00:00:00

abstract：:The identity of specific cell types in the nervous system is defined by the expression of neuron type-specific gene batteries. How the expression of such batteries is initiated during nervous system development has been under intensive study over the past few decades. However, comparatively little is known about how g...

journal_title：Nature neuroscience

authors： Deneris ES,Hobert O

更新日期：2014-07-01 00:00:00

abstract：:A localized transcriptome at the synapse facilitates synapse-, stimulus- and transcript-specific local protein synthesis in response to neuronal activity. While enzyme-mediated mRNA modifications are known to regulate cellular mRNA turnover, the role of these modifications in regulating synaptic RNA has not been studi...

journal_title：Nature neuroscience

authors： Merkurjev D,Hong WT,Iida K,Oomoto I,Goldie BJ,Yamaguti H,Ohara T,Kawaguchi SY,Hirano T,Martin KC,Pellegrini M,Wang DO

更新日期：2018-07-01 00:00:00

abstract：:Human chromosome 16p11.2 microdeletion is the most common gene copy number variation in autism, but the synaptic pathophysiology caused by this mutation is largely unknown. Using a mouse with the same genetic deficiency, we found that metabotropic glutamate receptor 5 (mGluR5)-dependent synaptic plasticity and protein...

journal_title：Nature neuroscience

authors： Tian D,Stoppel LJ,Heynen AJ,Lindemann L,Jaeschke G,Mills AA,Bear MF

更新日期：2015-02-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature neuroscience

authors： Farhan SMK,Howrigan DP,Abbott LE,Klim JR,Topp SD,Byrnes AE,Churchhouse C,Phatnani H,Smith BN,Rampersaud E,Wu G,Wuu J,Shatunov A,Iacoangeli A,Khleifat AA,Mordes DA,Ghosh S,ALSGENS Consortium.,FALS Consortium.,Project

更新日期：2020-02-01 00:00:00

abstract：:Speech and vocal impairments characterize many neurological disorders. However, the neurogenetic mechanisms of these disorders are not well understood, and current animal models do not have the necessary circuitry to recapitulate vocal learning deficits. We developed germline transgenic songbirds, zebra finches (Tanei...

journal_title：Nature neuroscience

authors： Liu WC,Kohn J,Szwed SK,Pariser E,Sepe S,Haripal B,Oshimori N,Marsala M,Miyanohara A,Lee R

更新日期：2015-11-01 00:00:00

abstract：:It is widely believed that attention selects locations at an earlier stage than it selects nonspatial features, but this has been tested only under conditions of minimal competition. We found that, when competition was increased, color-based attention was able to influence the feedforward flow of information in humans...

journal_title：Nature neuroscience

authors： Zhang W,Luck SJ

更新日期：2009-01-01 00:00:00

abstract：:Cuing covert spatial attention can increase spatial resolution. Here we pinpointed the specific locus of this effect using texture segmentation. At the level of visual cortex, texture segmentation theoretically involves passage of visual input through two layers of spatial linear filters separated by a pointwise nonli...

journal_title：Nature neuroscience

authors： Yeshurun Y,Carrasco M

更新日期：2000-06-01 00:00:00

abstract：:Striatal parvalbumin (PV) and cholinergic interneurons (CHIs) are poised to play major roles in behavior by coordinating the networks of medium spiny cells that relay motor output. However, the small numbers and scattered distribution of these cells have hindered direct assessment of their contribution to activity in ...

journal_title：Nature neuroscience

authors： Gritton HJ,Howe WM,Romano MF,DiFeliceantonio AG,Kramer MA,Saligrama V,Bucklin ME,Zemel D,Han X

更新日期：2019-04-01 00:00:00

abstract：:Using magnetoencephalography (MEG), we compared the processing of sinusoidal tones in the auditory cortex of 12 non-musicians, 12 professional musicians and 13 amateur musicians. We found neurophysiological and anatomical differences between groups. In professional musicians as compared to non-musicians, the activity ...

journal_title：Nature neuroscience

authors： Schneider P,Scherg M,Dosch HG,Specht HJ,Gutschalk A,Rupp A

更新日期：2002-07-01 00:00:00

abstract：:Many cells in retinotopic brain areas increase their activity when saccades (rapid eye movements) are about to bring stimuli into their receptive fields. Although previous work has attempted to look at the functional correlates of such predictive remapping, no study has explicitly tested for better attentional perform...

journal_title：Nature neuroscience

authors： Rolfs M,Jonikaitis D,Deubel H,Cavanagh P

更新日期：2011-02-01 00:00:00

abstract：:The meaning we derive from our experiences is not a simple static extraction of the elements but is largely based on the order in which those elements occur. Models propose that sequence encoding is supported by interactions between high- and low-frequency oscillations, such that elements within an experience are repr...

journal_title：Nature neuroscience

authors： Heusser AC,Poeppel D,Ezzyat Y,Davachi L

更新日期：2016-10-01 00:00:00