Abstract：
:Ability to integrate diverse forms of information in current thought, or working memory, is essential for human reasoning and problem solving. We used functional imaging to identify brain regions preferentially involved in maintaining integrated versus unintegrated information in working memory. For equal amounts of verbal and spatial information, activation of prefrontal cortex was greater for maintaining integrated rather than unintegrated representations. Posterior brain regions showed the opposite pattern. These results demonstrate frontal-lobe specialization in maintaining working-memory representations that integrate verbal and spatial information. The role of prefrontal cortex in integrating multiple forms of information in working memory may underlie its unique contribution to high-level cognition that demands flexible mental representations.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Prabhakaran V,Narayanan K,Zhao Z,Gabrieli JDdoi
10.1038/71156subject
Has Abstractpub_date
2000-01-01 00:00:00pages
85-90issue
1eissn
1097-6256issn
1546-1726journal_volume
3pub_type
临床试验,杂志文章abstract：:Forces developed by cochlear outer hair cells (OHCs) are responsible for the sharp tuning that underlies sensitivity and frequency selectivity in the ear. OHCs exhibit a voltage-dependent motility involving a 'motor' protein embedded in the basolateral membrane. The motor has so far resisted molecular identification. ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/11174
更新日期：1999-08-01 00:00:00
abstract：:Breathing is a bilaterally synchronous behavior that relies on a respiratory rhythm generator located in the brainstem. An essential component of this generator is the preBötzinger complex (preBötC), which paces inspirations. Little is known about the developmental origin of the interneuronal populations forming the p...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2622
更新日期：2010-09-01 00:00:00
abstract：:Aggression is a social behavior essential for securing resources and defending oneself and family. Thanks to its indispensable function in competition and thus survival, aggression exists widely across animal species, including humans. Classical works from Tinbergen and Lorenz concluded that instinctive behaviors incl...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
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abstract：:Individual behavioral performance during learning is known to be affected by modulatory factors, such as stress and motivation, and by genetic predispositions that influence sensitivity to these factors. Despite numerous studies, no integrative framework is available that could predict how a given animal would perform...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2374
更新日期：2009-09-01 00:00:00
abstract：:Brain-derived neurotrophic factor (BDNF) acting through the tyrosine kinase B receptor (TrkB) is thought to be a critical mediator of learning. As there are no available selective antagonists of TrkB, we used a lentivirus encoding a dominant-negative TrkB (TrkB.t1) to antagonize BDNF signaling during extinction of con...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1718
更新日期：2006-07-01 00:00:00
abstract：:Hippocampal replay during sharp-wave ripple events (SWRs) is thought to drive memory consolidation in hippocampal and cortical circuits. Changes in neocortical activity can precede SWR events, but whether and how these changes influence the content of replay remains unknown. Here we show that during sleep there is a r...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4457
更新日期：2017-02-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章,评审
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2750
更新日期：2011-03-01 00:00:00
abstract：:In the published version of this article, a data point is missing from Fig. 4f, and the y-axis label reads "RFpre"; it should read "RFpref." The original article has not been corrected. The original and corrected figures are shown in the accompanying Publisher Correction. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
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更新日期：2018-09-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4084
更新日期：2015-09-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2479
更新日期：2010-03-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3069
更新日期：2012-03-11 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3225
更新日期：2012-11-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章,评审
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更新日期：2012-11-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 评论,杂志文章,评审
doi：10.1038/nn0908-989
更新日期：2008-09-01 00:00:00
abstract：:Cocaine is a widely abused substance with psychostimulant effects that are attributed to inhibition of the dopamine transporter (DAT). We present molecular models for DAT binding of cocaine and cocaine analogs constructed from the high-resolution structure of the bacterial transporter homolog LeuT. Our models suggest ...
journal_title：Nature neuroscience
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更新日期：2008-07-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4328
更新日期：2016-08-01 00:00:00
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journal_title：Nature neuroscience
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更新日期：2011-10-23 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章,评审
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2015-02-01 00:00:00
abstract：:Much of the information processing in the brain occurs at the level of local circuits; however, the mechanisms underlying their initial development are poorly understood. We sought to examine the early development and plasticity of local excitatory circuits in the optic tectum of Xenopus laevis tadpoles. We found that...
journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2008-04-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
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pub_type： 已发布勘误
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更新日期：2020-02-01 00:00:00
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journal_title：Nature neuroscience
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更新日期：2000-10-01 00:00:00
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journal_title：Nature neuroscience
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更新日期：2019-01-01 00:00:00
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journal_title：Nature neuroscience
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