A small number of open Ca2+ channels trigger transmitter release at a central GABAergic synapse.

abstract：:Trafficking of AMPA receptors (AMPARs) is important for many forms of synaptic plasticity. However, the link between activity and resulting synaptic alterations is not fully understood. We identified a direct interaction between N-ethylmaleimide-sensitive fusion protein (NSF), an ATPase involved in membrane fusion eve...

journal_title：Nature neuroscience

authors： Evers DM,Matta JA,Hoe HS,Zarkowsky D,Lee SH,Isaac JT,Pak DT

更新日期：2010-10-01 00:00:00

abstract：:Recent evidence suggests that presynaptic-acting NMDA receptors (preNMDARs) are important for neocortical synaptic transmission and plasticity. We found that unique properties of the NR3A subunit enable preNMDARs to enhance spontaneous and evoked glutamate release and that NR3A is required for spike timing-dependent l...

journal_title：Nature neuroscience

authors： Larsen RS,Corlew RJ,Henson MA,Roberts AC,Mishina M,Watanabe M,Lipton SA,Nakanishi N,Pérez-Otaño I,Weinberg RJ,Philpot BD

更新日期：2011-03-01 00:00:00

abstract：:UTX is a chromatin modifier required for development and neural lineage specification, but how it controls these biological processes is unclear. To determine the molecular mechanisms of UTX, we identified novel UTX protein interaction partners. Here we show that UTX and 53BP1 directly interact and co-occupy promoters...

journal_title：Nature neuroscience

authors： Yang X,Xu B,Mulvey B,Evans M,Jordan S,Wang YD,Pagala V,Peng J,Fan Y,Patel A,Peng JC

更新日期：2019-03-01 00:00:00

abstract：:The orbitofrontal cortex plays a central role in good-based economic decisions. When subjects make choices, neurons in this region represent the identities and values of offered and chosen goods. Notably, choices in different behavioral contexts may involve a potentially infinite variety of goods. Thus a fundamental q...

journal_title：Nature neuroscience

authors： Xie J,Padoa-Schioppa C

更新日期：2016-06-01 00:00:00

abstract：:Neurons in thalamorecipient layers of sensory cortices integrate thalamocortical and intracortical inputs. Although we know that their functional properties can arise from the convergence of thalamic inputs, intracortical circuits could also be involved in thalamocortical transformations of sensory information. We sil...

journal_title：Nature neuroscience

authors： Li YT,Ibrahim LA,Liu BH,Zhang LI,Tao HW

更新日期：2013-09-01 00:00:00

abstract：:Sustained activity encoding visual working memory representations has been observed in several cortical areas of primates. Where along the visual pathways this activity emerges remains unknown. Here we show in macaques that sustained spiking activity encoding memorized visual motion directions is absent in direction-s...

journal_title：Nature neuroscience

authors： Mendoza-Halliday D,Torres S,Martinez-Trujillo JC

更新日期：2014-09-01 00:00:00

abstract：:During development, the mammalian ventral telencephalon is comprised of three major proliferative zones: the medial (MGE), lateral (LGE) and caudal (CGE) ganglionic eminences. Through gene expression studies, in vitro migration assays, genetic mutant analysis and in vivo fate mapping in mice, we found that the CGE is ...

journal_title：Nature neuroscience

authors： Nery S,Fishell G,Corbin JG

更新日期：2002-12-01 00:00:00

abstract：:The 'cognitive map' hypothesis proposes that brain builds a unified representation of the spatial environment to support memory and guide future action. Forty years of electrophysiological research in rodents suggest that cognitive maps are neurally instantiated by place, grid, border and head direction cells in the h...

journal_title：Nature neuroscience

authors： Epstein RA,Patai EZ,Julian JB,Spiers HJ

更新日期：2017-10-26 00:00:00

abstract：:Short-term synaptic plasticity is a defining feature of neuronal activity, but the underlying molecular mechanisms are poorly understood. Depression of synaptic activity might be due to limited vesicle availability, whereas facilitation is thought to result from elevated calcium levels. However, it is unclear whether ...

journal_title：Nature neuroscience

authors： Sippy T,Cruz-Martín A,Jeromin A,Schweizer FE

更新日期：2003-10-01 00:00:00

abstract：:Multiple protein kinase C (PKC) isozymes are present in neurons, where they regulate a variety of cellular functions. Due to the lack of specific PKC isozyme inhibitors, it remains unknown how PKC acts on its selective target(s) and achieves its specific actions. Here we show that a PKC binding protein, enigma homolog...

journal_title：Nature neuroscience

authors： Maeno-Hikichi Y,Chang S,Matsumura K,Lai M,Lin H,Nakagawa N,Kuroda S,Zhang JF

更新日期：2003-05-01 00:00:00

abstract：:Neurons in many species have large receptive fields that are selective for specific optic flow fields. Here, we studied the neural mechanisms underlying flow field selectivity in lobula plate tangential cells (LPTCs) of the blowfly. Among these cells, the H2 cell responds preferentially to visual stimuli approximating...

journal_title：Nature neuroscience

authors： Farrow K,Haag J,Borst A

更新日期：2006-10-01 00:00:00

abstract：:To investigate synaptic events underlying sensory perception, we made whole-cell membrane potential recordings of barrel cortex neurons in awake mice while recording whisker-related behavior. During quiet periods, we recorded slow, large-amplitude membrane potential changes, which switched during whisking to small, fa...

journal_title：Nature neuroscience

authors： Crochet S,Petersen CC

更新日期：2006-05-01 00:00:00

abstract：:It is unclear how knowledge of one's actions and one's body contribute to the understanding of others' actions. Here we show that two subjects lacking cutaneous touch and sense of movement and position show a selective deficit in interpreting another person's anticipation of weight when seeing him lifting boxes. We su...

journal_title：Nature neuroscience

authors： Bosbach S,Cole J,Prinz W,Knoblich G

更新日期：2005-10-01 00:00:00

abstract：:At glutamatergic synapses, calcium influx through NMDA receptors (NMDARs) is required for long-term potentiation (LTP); this is a proposed cellular mechanism underlying memory and learning. Here we show that in lateral amygdala pyramidal neurons, SK channels are also activated by calcium influx through synaptically ac...

journal_title：Nature neuroscience

authors： Faber ES,Delaney AJ,Sah P

更新日期：2005-05-01 00:00:00

abstract：:By analyzing the whole-exome sequences of 4,264 schizophrenia cases, 9,343 controls and 1,077 trios, we identified a genome-wide significant association between rare loss-of-function (LoF) variants in SETD1A and risk for schizophrenia (P = 3.3 × 10(-9)). We found only two heterozygous LoF variants in 45,376 exomes fro...

journal_title：Nature neuroscience

authors： Singh T,Kurki MI,Curtis D,Purcell SM,Crooks L,McRae J,Suvisaari J,Chheda H,Blackwood D,Breen G,Pietiläinen O,Gerety SS,Ayub M,Blyth M,Cole T,Collier D,Coomber EL,Craddock N,Daly MJ,Danesh J,DiForti M,Foster A,

更新日期：2016-04-01 00:00:00

abstract：:Contrast is computed throughout the nervous system to encode changing inputs efficiently. The retina encodes luminance and contrast over a wide range of visual conditions and must adapt its responses to maintain sensitivity and to avoid saturation. We examined the means by which one type of adaptation allows individua...

journal_title：Nature neuroscience

authors： Oesch NW,Diamond JS

更新日期：2011-10-23 00:00:00

abstract：:The most critical attribute of human language is its unbounded combinatorial nature: smaller elements can be combined into larger structures on the basis of a grammatical system, resulting in a hierarchy of linguistic units, such as words, phrases and sentences. Mentally parsing and representing such structures, howev...

journal_title：Nature neuroscience

authors： Ding N,Melloni L,Zhang H,Tian X,Poeppel D

更新日期：2016-01-01 00:00:00

abstract：:Cocaine is a widely abused substance with psychostimulant effects that are attributed to inhibition of the dopamine transporter (DAT). We present molecular models for DAT binding of cocaine and cocaine analogs constructed from the high-resolution structure of the bacterial transporter homolog LeuT. Our models suggest ...

journal_title：Nature neuroscience

authors： Beuming T,Kniazeff J,Bergmann ML,Shi L,Gracia L,Raniszewska K,Newman AH,Javitch JA,Weinstein H,Gether U,Loland CJ

更新日期：2008-07-01 00:00:00

abstract：:Arcuate nucleus (ARC) neurons sense the fed or fasted state and regulate hunger. Agouti-related protein (AgRP) neurons in the ARC (ARCAgRP neurons) are stimulated by fasting and, once activated, they rapidly (within minutes) drive hunger. Pro-opiomelanocortin (ARCPOMC) neurons are viewed as the counterpoint to ARCAgRP...

journal_title：Nature neuroscience

authors： Fenselau H,Campbell JN,Verstegen AM,Madara JC,Xu J,Shah BP,Resch JM,Yang Z,Mandelblat-Cerf Y,Livneh Y,Lowell BB

更新日期：2017-01-01 00:00:00

abstract：:We used high-level configural aftereffects induced by adaptation to realistic faces to investigate visual representations underlying complex pattern perception. We found that exposure to an individual face for a few seconds generated a significant and precise bias in the subsequent perception of face identity. In the ...

journal_title：Nature neuroscience

authors： Leopold DA,O'Toole AJ,Vetter T,Blanz V

更新日期：2001-01-01 00:00:00

abstract：:Every year in the United States, an estimated 500,000 babies are born preterm (before 37 completed weeks of gestation), and this number is rising, along with the recognition of brain injuries due to preterm delivery. A common underlying pathogenesis appears to be perinatal hypoxia induced by immature lung development,...

journal_title：Nature neuroscience

authors： Salmaso N,Jablonska B,Scafidi J,Vaccarino FM,Gallo V

更新日期：2014-03-01 00:00:00

abstract：:In vivo model systems are a critical tool for gaining insight into the pathology underlying psychiatric disorders. Although modern functional imaging tools allow study of brain correlates of behavior in clinical groups and genome-wide association studies are beginning to uncover the complex genetic architecture of psy...

journal_title：Nature neuroscience

authors： Averbeck BB,Chafee MV

更新日期：2016-11-01 00:00:00

abstract：:It has been debated whether orientation selectivity in mouse primary visual cortex (V1) is derived from tuned lateral geniculate nucleus (LGN) inputs or computed from untuned LGN inputs. However, few studies have measured orientation tuning of LGN axons projecting to V1. We measured the response properties of mouse LG...

journal_title：Nature neuroscience

authors： Kondo S,Ohki K

更新日期：2016-02-01 00:00:00

abstract：:Adult expertise in face processing is mediated largely by neural networks in the right hemisphere. Here we evaluate the contribution of early visual input in establishing this neural substrate. We compared visually normal individuals to patients for whom visual input had been restricted mainly to one hemisphere during...

journal_title：Nature neuroscience

authors： Le Grand R,Mondloch CJ,Maurer D,Brent HP

更新日期：2003-10-01 00:00:00

abstract：:The cerebral cortex has the ability to adapt to altered sensory inputs. In the visual cortex, a small lesion to the retina causes the deprived cortical region to become responsive to adjacent parts of the visual field. This extensive topographic remapping is assumed to be mediated by the rewiring of intracortical conn...

journal_title：Nature neuroscience

authors： Keck T,Mrsic-Flogel TD,Vaz Afonso M,Eysel UT,Bonhoeffer T,Hübener M

更新日期：2008-10-01 00:00:00

abstract：:Chronic morphine exposure upregulates adenylate cyclase signaling and reduces analgesic efficacy, a condition known as opioid tolerance. Nonopioid neurotransmitters can enhance morphine tolerance, but the mechanism for this is poorly understood. We show that morphine tolerance was delayed in mice lacking vasopressin 1...

journal_title：Nature neuroscience

authors： Koshimizu TA,Honda K,Nagaoka-Uozumi S,Ichimura A,Kimura I,Nakaya M,Sakai N,Shibata K,Ushijima K,Fujimura A,Hirasawa A,Kurose H,Tsujimoto G,Tanoue A,Takano Y

更新日期：2018-06-01 00:00:00

abstract：:Declarative memory, the conscious recollection of past experiences, is known to involve the hippocampus. Now a study of amnesic patients shows that hippocampus-dependent learning can occur in the absence of conscious awareness. ...

journal_title：Nature neuroscience

authors： Eichenbaum H

更新日期：1999-09-01 00:00:00

abstract：:Neuroscientists increasingly analyze the joint activity of multineuron recordings to identify population-level structures believed to be significant and scientifically novel. Claims of significant population structure support hypotheses in many brain areas. However, these claims require first investigating the possibi...

journal_title：Nature neuroscience

authors： Elsayed GF,Cunningham JP

更新日期：2017-09-01 00:00:00

abstract：:Behavior-contingent network oscillations bring about transient, functionally coherent neuronal assemblies in the cerebral cortex, including the hippocampus. Inhibitory input on and close to the soma is believed to phase intrinsic oscillations and output of pyramidal cells, but the function of GABA release to pyramidal...

journal_title：Nature neuroscience

authors： Klausberger T,Márton LF,Baude A,Roberts JD,Magill PJ,Somogyi P

更新日期：2004-01-01 00:00:00

abstract：:In the postnatal subventricular zone (SVZ), local cues or signaling molecules released from neuroblasts limit the proliferation of glial fibrillary acidic protein (GFAP)-expressing progenitors thought to be stem cells. However, signals between SVZ cells have not been identified. We show that depolarization of neurobla...

journal_title：Nature neuroscience

authors： Liu X,Wang Q,Haydar TF,Bordey A

更新日期：2005-09-01 00:00:00