Abstract：
:Dot patterns sliding transparently across one another are normally perceived as independently moving surfaces. Recordings from direction-selective neurons in area MT of the macaque suggested that this perceptual segregation did not depend on the presence of two peaks in the population activity. Rather, the visual system seemed to use overall shape of the population response to determine the number and directions of motion components. This approach explained a number of perceptual phenomena, including susceptibility of the motion system to direction metamers, motion patterns combining three or five directions incorrectly perceived by subjects as comprising only two directions. Our findings offer insights into the coding of multi-valued sensory signals and provide constraints for biologically based computational models.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Treue S,Hol K,Rauber HJdoi
10.1038/72985subject
Has Abstractpub_date
2000-03-01 00:00:00pages
270-6issue
3eissn
1097-6256issn
1546-1726journal_volume
3pub_type
杂志文章abstract：:Exposure to a stressor sensitizes behavioral and hormonal responses to future stressors. Stress-associated release of noradrenaline enhances the capacity of central synapses to show plasticity (metaplasticity). We found noradrenaline-dependent metaplasticity at GABA synapses in the paraventricular nucleus of the hypot...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3373
更新日期：2013-05-01 00:00:00
abstract：:Intrinsic signal imaging from inferotemporal (IT) cortex, a visual area essential for object perception and recognition, revealed that visually presented objects activated patches in a distributed manner. When visual features of these objects were partially removed, the simplified stimuli activated only a subset of th...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/90547
更新日期：2001-08-01 00:00:00
abstract：:Exposures to cocaine and morphine produce similar adaptations in nucleus accumbens (NAc)-based behaviors, yet produce very different adaptations at NAc excitatory synapses. In an effort to explain this paradox, we found that both drugs induced NMDA receptor-containing, AMPA receptor-silent excitatory synapses, albeit ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4313
更新日期：2016-07-01 00:00:00
abstract：:Head-direction cells have frequently been regarded as an internal 'compass' that can be used for navigation, although there is little evidence showing a link between their activity and spatial behavior. In a navigational task requiring the use of internal cues to return to a home location without vision (path integrat...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3215
更新日期：2012-10-01 00:00:00
abstract：:We elucidated the intrinsic circuitry of the medial prefrontal cortex and its role in regulating fear extinction, using neuronal tracing and optogenetic stimulation in vitro and in vivo. We show that pyramidal neurons in layer 5/6 of the prelimbic medial prefrontal cortex project to pyramidal cells in layer 5/6 of the...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0137-x
更新日期：2018-05-01 00:00:00
abstract：:Cell type-specific expression of optogenetic molecules allows temporally precise manipulation of targeted neuronal activity. Here we present a toolbox of four knock-in mouse lines engineered for strong, Cre-dependent expression of channelrhodopsins ChR2-tdTomato and ChR2-EYFP, halorhodopsin eNpHR3.0 and archaerhodopsi...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3078
更新日期：2012-03-25 00:00:00
abstract：:Electrical stimulation of visual cortex can produce a visual percept (phosphene). We electrically stimulated visual cortex in humans implanted with subdural electrodes while recording from other brain sites. Phosphene perception occurred only if stimulation evoked high-frequency gamma oscillations in the temporopariet...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3131
更新日期：2012-06-03 00:00:00
abstract：:Odor stimulation evokes complex spatiotemporal activity in the olfactory bulb, suggesting that both the identity of activated neurons and the timing of their activity convey information about odors. However, whether and how downstream neurons decipher these temporal patterns remains unknown. We addressed this question...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3407
更新日期：2013-07-01 00:00:00
abstract：:Dopaminergic (DA) signaling governs the control of complex behaviors, and its deregulation has been implicated in a wide range of diseases. Here we demonstrate that inactivation of the Fto gene, encoding a nucleic acid demethylase, impairs dopamine receptor type 2 (D2R) and type 3 (D3R) (collectively, 'D2-like recepto...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3449
更新日期：2013-08-01 00:00:00
abstract：:Mutations in MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT). The RTT missense MECP2R306C mutation prevents MeCP2 from interacting with the NCoR/histone deacetylase 3 (HDAC3) complex; however, the neuronal function of HDAC3 is incompletely understood. We found that neuronal deletion of Hdac3 in mice el...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4347
更新日期：2016-11-01 00:00:00
abstract：:Most advances in addiction treatment to date have addressed the physical dependence and withdrawal that accompany addiction to some drugs of abuse. In contrast, it has proven more difficult to develop medications that effectively treat drug craving and relapse, the core features of addictive disorders. Current efforts...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn945
更新日期：2002-11-01 00:00:00
abstract：:The precise role of synchronous neuronal firing in signal encoding remains unclear. To examine what kinds of signals can be carried by synchrony, I reproduced a multilayer feedforward network of neurons in an in vitro slice preparation of rat cortex using an iterative procedure. When constant and time-varying frequenc...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1056
更新日期：2003-06-01 00:00:00
abstract：:The endocytosis of AMPA receptors is thought to be important in the expression of long-term depression (LTD) triggered by NMDA receptor activation. Although signaling pathways necessary for LTD induction have been identified, those responsible for the regulated internalization of AMPA receptors are unknown. Here we sh...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/81823
更新日期：2000-12-01 00:00:00
abstract：:Learning to adapt to a complex and fluctuating environment requires the ability to adjust neural representations of sensory stimuli. Through pattern completion processes, cortical networks can reconstruct familiar patterns from degraded input patterns, whereas pattern separation processes allow discrimination of even ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2966
更新日期：2011-11-20 00:00:00
abstract：:Enduring deficits in temporal processing can be induced in the auditory cortex by rearing infant rats in the presence of low frequency-modulated noises. We found that it was possible to restore normal temporal processing, overcoming deficits induced during the critical period, by intensively training developmentally i...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2239
更新日期：2009-01-01 00:00:00
abstract：:Many neural signaling receptors are regulated by endocytosis, but little is known about receptor insertion into the plasma membrane. Time-lapse imaging of the beta2 adrenergic receptor expressed in cultured rat hippocampal neurons, using pH-sensitive green fluorescent protein tagging and total internal reflection fluo...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1679
更新日期：2006-05-01 00:00:00
abstract：:Over the last 10 years, optogenetics has become widespread in neuroscience for the study of how specific cell types contribute to brain functions and brain disorder states. The full impact of optogenetics will emerge only when other toolsets mature, including neural connectivity and cell phenotyping tools and neural r...
journal_title：Nature neuroscience
pub_type： 评论,杂志文章
doi：10.1038/nn.4094
更新日期：2015-09-01 00:00:00
abstract：:Cannabis is the most frequently used illicit psychoactive substance worldwide; around one in ten users become dependent. The risk for cannabis use disorder (CUD) has a strong genetic component, with twin heritability estimates ranging from 51 to 70%. Here we performed a genome-wide association study of CUD in 2,387 ca...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0416-1
更新日期：2019-07-01 00:00:00
abstract：:Neuronal differentiation is accomplished through cascades of intrinsic genetic factors initiated in neuronal progenitors by external gradients of morphogens. Activity has been thought to be important only late in development, but recent evidence suggests that activity also regulates early neuronal differentiation. Act...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2582
更新日期：2010-08-01 00:00:00
abstract：:Two studies in this issue show that the protein MeCP2, which is implicated in Rett syndrome, also critically regulates behavioral responses to psychostimulants. Although the two studies highlight different mechanisms of MeCP2 in regulating these behaviors, both underscore the importance of epigenetic mechanisms in est...
journal_title：Nature neuroscience
pub_type： 评论,新闻
doi：10.1038/nn0910-1039
更新日期：2010-09-01 00:00:00
abstract：:EphAs and ephrinAs are expressed in multiple areas of the developing brain in overlapping countergradients, notably in the retina and tectum. Here they are involved in targeting retinal axons to their correct topographic position in the tectum. We have used truncated versions of EphA3, single-amino acid point mutants ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1655
更新日期：2006-03-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-020-00723-2
更新日期：2020-11-01 00:00:00
abstract：:The endocytosis of AMPA receptors (AMPARs) underlies several forms of synaptic plasticity, including NMDA receptor (NMDAR)-dependent long-term depression (LTD), but the molecular mechanisms responsible for this trafficking remain unknown. We found that PSD-95, a major postsynaptic density protein, is important for NMD...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2249
更新日期：2009-02-01 00:00:00
abstract：:The launch of the US BRAIN and European Human Brain Projects coincides with growing international efforts toward transparency and increased access to publicly funded research in the neurosciences. The need for data-sharing standards and neuroinformatics infrastructure is more pressing than ever. However, 'big science'...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.3838
更新日期：2014-11-01 00:00:00
abstract：:We report on two brain-damaged subjects who exhibit the uncommon pattern of loss of object color knowledge, but spared color perception and naming. The subject P.C.O., as in previously reported patients, is also impaired in processing other perceptual and functional properties of objects. I.O.C., in contrast, is the f...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/88497
更新日期：2001-06-01 00:00:00
abstract：:The cortical nucleus LMAN (lateral magnocellular nucleus of the anterior nidopallium) provides the output of a basal ganglia pathway that is necessary for vocal learning in juvenile songbirds. The shell subregion of LMAN (LMAN(shell)) gives rise to recurrent loops that may subserve specific learning-related functions....
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2472
更新日期：2010-02-01 00:00:00
abstract：:Adult neurogenesis occurs in the hippocampus and the olfactory bulb of the mammalian CNS. Recent studies have demonstrated that newborn granule cells of the adult hippocampus are postsynaptic targets of excitatory and inhibitory neurons, but evidence of synapse formation by the axons of these cells is still lacking. B...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2156
更新日期：2008-08-01 00:00:00
abstract：:The output of cortical columns is routed to different downstream targets via distinct pathways: cortico-cortical and cortico-subcortical. It is as yet unclear what roles these pathways play in perception, and which cellular and circuit mechanisms regulate their gating. We recently showed that activation of the apical ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-0677-8
更新日期：2020-10-01 00:00:00
abstract：:Three families of ligand-activated ion channels mediate synaptic communication between excitable cells in mammals. For pentameric channels related to nicotinic acetylcholine receptors and tetrameric channels such as glutamate receptors, the pore-forming and gate regions have been studied extensively. In contrast, litt...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2151
更新日期：2008-08-01 00:00:00
abstract：:The contribution of basal ganglia outputs to consummatory behavior remains poorly understood. We recorded from the substantia nigra pars reticulata (SNR), the major basal ganglia output nucleus, during self-initiated drinking in mice. The firing rates of many lateral SNR neurons were time-locked to individual licks. T...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4285
更新日期：2016-05-01 00:00:00
