Abstract:
:We elucidated the intrinsic circuitry of the medial prefrontal cortex and its role in regulating fear extinction, using neuronal tracing and optogenetic stimulation in vitro and in vivo. We show that pyramidal neurons in layer 5/6 of the prelimbic medial prefrontal cortex project to pyramidal cells in layer 5/6 of the infralimbic cortex. Activation of this connection enhances fear extinction, redefining the role of the prelimbic cortex in extinction learning.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Marek R,Xu L,Sullivan RKP,Sah Pdoi
10.1038/s41593-018-0137-xsubject
Has Abstractpub_date
2018-05-01 00:00:00pages
654-658issue
5eissn
1097-6256issn
1546-1726pii
10.1038/s41593-018-0137-xjournal_volume
21pub_type
杂志文章abstract::Shared neural variability is ubiquitous in cortical populations. While this variability is presumed to arise from overlapping synaptic input, its precise relationship to local circuit architecture remains unclear. We combine computational models and in vivo recordings to study the relationship between the spatial stru...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4433
更新日期:2017-01-01 00:00:00
abstract::Sharp wave-ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2384
更新日期:2009-10-01 00:00:00
abstract::Hippocampal long-term potentiation (LTP) induced by theta-burst pairing of Schaffer collateral inputs and postsynaptic firing is associated with localized increases in synaptic strength and dendritic excitability. Using the same protocol, we now demonstrate a decrease in cellular excitability that was blocked by the h...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1568
更新日期:2005-11-01 00:00:00
abstract::Laboratory models, including animal tissues and live animals, have proven useful for discovery of molecular targets of alcohol action as well as for characterization of genetic and environmental factors that influence alcohol's neural actions. Here we consider strengths and weaknesses of laboratory models used in alco...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn1581
更新日期:2005-11-01 00:00:00
abstract::Sensory neural systems use spatiotemporal coding mechanisms to represent stimuli. These time-varying response patterns sometimes outlast the stimulus. Can the temporal structure of a stimulus interfere with, or even disrupt, the spatiotemporal structure of the neural representation? We investigated this potential conf...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1559
更新日期:2005-11-01 00:00:00
abstract::Ongoing sensory input is critical for shaping internal representations of the external world. Conversely, a lack of sensory input can profoundly perturb the formation of these representations. The olfactory system is particularly vulnerable to sensory deprivation, owing to the widespread prevalence of allergic, viral ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3186
更新日期:2012-09-01 00:00:00
abstract::A picture viewed from its center of projection generates the same retinal image as the original scene, so the viewer perceives the scene correctly. When a picture is viewed from other locations, the retinal image specifies a different scene, but we normally do not notice the changes. We investigated the mechanism unde...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1553
更新日期:2005-10-01 00:00:00
abstract::Olfactory representations are shaped by brain state and respiration. The interaction and circuit substrates of these influences are unclear. Granule cells (GCs) in the main olfactory bulb (MOB) are presumed to sculpt activity reaching the cortex via inhibition of mitral/tufted cells (MTs). GCs potentially make ensembl...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3669
更新日期:2014-04-01 00:00:00
abstract::Ability to integrate diverse forms of information in current thought, or working memory, is essential for human reasoning and problem solving. We used functional imaging to identify brain regions preferentially involved in maintaining integrated versus unintegrated information in working memory. For equal amounts of v...
journal_title:Nature neuroscience
pub_type: 临床试验,杂志文章
doi:10.1038/71156
更新日期:2000-01-01 00:00:00
abstract::Some individuals maintain high cognitive functioning at older ages. Here we show that mechanisms for long-term depression differ in aged rodents that maintain cognitive performance compared to young adults. Our results imply that cognitive abilities may be sustained in aged individuals by a switch in synaptic plastici...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1586
更新日期:2005-12-01 00:00:00
abstract::A brief visual target stimulus may be rendered invisible if it is immediately preceded or followed by another stimulus. This class of illusions, known as visual masking, may allow insights into the neural mechanisms that underlie visual perception. We have therefore explored the temporal characteristics of masking ill...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/393
更新日期:1998-06-01 00:00:00
abstract::Unifying principles of movement have emerged from the computational study of motor control. We review several of these principles and show how they apply to processes such as motor planning, control, estimation, prediction and learning. Our goal is to demonstrate how specific models emerging from the computational app...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/81497
更新日期:2000-11-01 00:00:00
abstract::Understanding the transcriptional changes that are engaged in stress resilience may reveal novel antidepressant targets. Here we use gene co-expression analysis of RNA-sequencing data from brains of resilient mice to identify a gene network that is unique to resilience. Zfp189, which encodes a previously unstudied zin...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0462-8
更新日期:2019-09-01 00:00:00
abstract::The subunit composition of postsynaptic non-NMDA-type glutamate receptors (GluRs) determines the function and trafficking of the receptor. Changes in GluR composition have been implicated in the homeostasis of neuronal excitability and synaptic plasticity underlying learning. Here, we imaged GluRs in vivo during the f...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2122
更新日期:2008-06-01 00:00:00
abstract::Information analysis shows that face-selective neurons in inferior temporal cortex encode different stimulus attributes early and late in their response to the same image. ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/13149
更新日期:1999-10-01 00:00:00
abstract::Nature Neuroscience presents a special issue of recent advances on shared mechanisms underlying neurodegenerative disease. ...
journal_title:Nature neuroscience
pub_type: 社论
doi:10.1038/s41593-018-0250-x
更新日期:2018-10-01 00:00:00
abstract::The shift in ocular dominance induced by brief monocular deprivation is greatest during a postnatal critical period and is thought to decline irreversibly thereafter. However, here we demonstrate that complete visual deprivation through dark exposure restores rapid ocular dominance plasticity in adult rats. In additio...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1965
更新日期:2007-09-01 00:00:00
abstract::In the version of this article initially published, the annotation accompanying ref. 47 ended with "though the modulation of microglia." The first word of this phrase should have been "through." The error has been corrected in the HTML and PDF versions of the article. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-018-0186-1
更新日期:2018-08-01 00:00:00
abstract::In the nose, odorants are detected on the cilia of olfactory sensory neurons (OSNs), where a cAMP-mediated signaling pathway transforms odor stimulation into electrical responses. Phosphodiesterase (PDE) activity in OSN cilia has long been thought to account for rapid response termination by degrading odor-induced cAM...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2289
更新日期:2009-04-01 00:00:00
abstract::Uncovering structural regularities and architectural topologies of cortical circuitry is vital for understanding neural computations. Recently, an experimentally constrained algorithm generated a dense network reconstruction of a ∼0.3-mm3 volume from juvenile rat somatosensory neocortex, comprising ∼31,000 cells and ∼...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4576
更新日期:2017-07-01 00:00:00
abstract::Transposable elements, known colloquially as 'jumping genes', constitute approximately 45% of the human genome. Cells utilize epigenetic defenses to limit transposable element jumping, including formation of silencing heterochromatin and generation of piwi-interacting RNAs (piRNAs), small RNAs that facilitate clearanc...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0194-1
更新日期:2018-08-01 00:00:00
abstract::The balance between proliferation and apoptosis is critical for proper development of the nervous system. Yet, little is known about molecules that regulate apoptosis of proliferative neurons. Here we identify a soluble, secreted form of CPG15 expressed in embryonic rat brain regions undergoing rapid proliferation and...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1407
更新日期:2005-03-01 00:00:00
abstract::Intrinsic signal imaging from inferotemporal (IT) cortex, a visual area essential for object perception and recognition, revealed that visually presented objects activated patches in a distributed manner. When visual features of these objects were partially removed, the simplified stimuli activated only a subset of th...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/90547
更新日期:2001-08-01 00:00:00
abstract::The US government is re-examining how it funds science, but it remains to be seen whether the administration can overcome tradition and bureaucratic inertia and achieve a substantial renovation of the grants peer-review system. ...
journal_title:Nature neuroscience
pub_type: 社论
doi:10.1038/nn0208-119
更新日期:2008-02-01 00:00:00
abstract::Interleukin 17 (IL-17) is a signature cytokine of Th17 cells. We previously reported that deletion of NF-κB activator 1 (Act1), the key transducer of IL-17 receptor signaling, from the neuroectodermal lineage in mice (neurons, oligodendrocytes and astrocytes) results in attenuated severity of experimental autoimmune e...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3505
更新日期:2013-10-01 00:00:00
abstract::Neurobiological theories of knowledge processing are biased toward the language-dominant (usually the left) hemisphere. Does the right hemisphere critically contribute to knowledge processing? J.A. is a left-hemisphere language-dominant individual who suffered a lesion confined to the right mid- and anterior fusiform ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1721
更新日期:2006-07-01 00:00:00
abstract::Microglia are primary immune sentinels of the CNS. Following injury, these cells migrate or extend processes toward sites of tissue damage. CNS injury is accompanied by release of nucleotides, serving as signals for microglial activation or chemotaxis. Microglia express several purinoceptors, including a G(i)-coupled ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1805
更新日期:2006-12-01 00:00:00
abstract::Neuronal differentiation is accomplished through cascades of intrinsic genetic factors initiated in neuronal progenitors by external gradients of morphogens. Activity has been thought to be important only late in development, but recent evidence suggests that activity also regulates early neuronal differentiation. Act...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2582
更新日期:2010-08-01 00:00:00
abstract::Class I histone deacetylases (HDACs) Hdac1 and Hdac2 can associate together in protein complexes with transcriptional factors such as methyl-CpG-binding protein 2 (MeCP2). Given their high degree of sequence identity, we examined whether Hdac1 and Hdac2 were functionally redundant in mature mouse brain. We demonstrate...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4395
更新日期:2016-11-01 00:00:00
abstract::Here we used magnetoencephalography (MEG) to investigate stages of processing in face perception in humans. We found a face-selective MEG response occurring only 100 ms after stimulus onset (the 'M100'), 70 ms earlier than previously reported. Further, the amplitude of this M100 response was correlated with successful...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn909
更新日期:2002-09-01 00:00:00