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The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke.

Abstract：

:Phagocytic cell NADPH oxidase (NOX) generates reactive oxygen species (ROS) as part of innate immunity. Unfortunately, ischemia can also induce this pathway and inflict damage on native cells. The voltage-gated proton channel Hv1 enables NOX function by compensating cellular loss of electrons with protons. Accordingly, we investigated whether NOX-mediated brain damage in stroke can be inhibited by suppression of Hv1. We found that mouse and human brain microglia, but not neurons or astrocytes, expressed large Hv1-mediated currents. Hv1 was required for NOX-dependent ROS generation in brain microglia in situ and in vivo. Mice lacking Hv1 were protected from NOX-mediated neuronal death and brain damage 24 h after stroke. These results indicate that Hv1-dependent ROS production is responsible for a substantial fraction of brain damage at early time points after ischemic stroke and provide a rationale for Hv1 as a therapeutic target for the treatment of ischemic stroke.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Wu LJ,Wu G,Akhavan Sharif MR,Baker A,Jia Y,Fahey FH,Luo HR,Feener EP,Clapham DE

doi

10.1038/nn.3059

subject

Has Abstract

pub_date

2012-03-04 00:00:00

pages

565-73

issue

4

eissn

1097-6256

issn

1546-1726

pii

nn.3059

journal_volume

15

pub_type

杂志文章

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