Male pheromone-stimulated neurogenesis in the adult female brain: possible role in mating behavior.

abstract：:Memory is supported by a specific ensemble of neurons distributed in the brain that form a unique memory trace. We previously showed that neurons in the lateral amygdala expressing elevated levels of cAMP response-element binding protein are preferentially recruited into fear memory traces and are necessary for the ex...

journal_title：Nature neuroscience

authors： Kim J,Kwon JT,Kim HS,Josselyn SA,Han JH

更新日期：2014-01-01 00:00:00

abstract：:Human neurodegenerative disorders are among the most difficult to study. In particular, the inability to readily obtain the faulty cell types most relevant to these diseases has impeded progress for decades. Recent advances in pluripotent stem cell technology now grant access to substantial quantities of disease-perti...

journal_title：Nature neuroscience

authors： Sandoe J,Eggan K

更新日期：2013-07-01 00:00:00

abstract：:The contribution of basal ganglia outputs to consummatory behavior remains poorly understood. We recorded from the substantia nigra pars reticulata (SNR), the major basal ganglia output nucleus, during self-initiated drinking in mice. The firing rates of many lateral SNR neurons were time-locked to individual licks. T...

journal_title：Nature neuroscience

authors： Rossi MA,Li HE,Lu D,Kim IH,Bartholomew RA,Gaidis E,Barter JW,Kim N,Cai MT,Soderling SH,Yin HH

更新日期：2016-05-01 00:00:00

abstract：:Synaptic vesicles release neurotransmitter both actively (on stimulation) and spontaneously (at rest). It has been assumed that identical vesicles use both modes of release; however, recent evidence has challenged this view. Using several assays (FM dye imaging, pHluorin imaging and antibody-labeling of synaptotagmin)...

journal_title：Nature neuroscience

authors： Wilhelm BG,Groemer TW,Rizzoli SO

更新日期：2010-12-01 00:00:00

abstract：:Human behavior is mostly composed of habitual actions that require little conscious control. Such actions may become invalid if the environment changes, at which point individuals need to switch behavior by overcoming habitual actions that are otherwise triggered automatically. It is unknown how the brain controls thi...

journal_title：Nature neuroscience

authors： Isoda M,Hikosaka O

更新日期：2007-02-01 00:00:00

abstract：:Imaging, from magnetic resonance imaging (MRI) to localization of specific macromolecules by microscopies, has been one of the driving forces behind neuroinformatics efforts of the past decade. Many web-accessible resources have been created, ranging from simple data collections to highly structured databases. Althoug...

journal_title：Nature neuroscience

authors： Martone ME,Gupta A,Ellisman MH

更新日期：2004-05-01 00:00:00

abstract：:Entorhinal grid cells in mammals fire as a function of animal location, with spatially periodic response patterns. This nonlocal periodic representation of location, a local variable, is unlike other neural codes. There is no theoretical explanation for why such a code should exist. We examined how accurately the grid...

journal_title：Nature neuroscience

authors： Sreenivasan S,Fiete I

更新日期：2011-09-11 00:00:00

abstract：:Many types of neurons can release endocannabinoids that act as retrograde signals to inhibit neurotransmitter release from presynaptic terminals. Little is known, however, about the properties or role of such inhibition under physiological conditions. Here we report that brief bursts of presynaptic activity evoked end...

journal_title：Nature neuroscience

authors： Brown SP,Brenowitz SD,Regehr WG

更新日期：2003-10-01 00:00:00

abstract：:Tumor-associated macrophages (TAMs) play an important role in the immune response to cancer, but the mechanisms by which the tumor microenvironment controls TAMs and T cell immunity are not completely understood. Here we report that kynurenine produced by glioblastoma cells activates aryl hydrocarbon receptor (AHR) in...

journal_title：Nature neuroscience

authors： Takenaka MC,Gabriely G,Rothhammer V,Mascanfroni ID,Wheeler MA,Chao CC,Gutiérrez-Vázquez C,Kenison J,Tjon EC,Barroso A,Vandeventer T,de Lima KA,Rothweiler S,Mayo L,Ghannam S,Zandee S,Healy L,Sherr D,Farez MF,Prat A,

更新日期：2019-05-01 00:00:00

abstract：:Recent evidence suggests that presynaptic-acting NMDA receptors (preNMDARs) are important for neocortical synaptic transmission and plasticity. We found that unique properties of the NR3A subunit enable preNMDARs to enhance spontaneous and evoked glutamate release and that NR3A is required for spike timing-dependent l...

journal_title：Nature neuroscience

authors： Larsen RS,Corlew RJ,Henson MA,Roberts AC,Mishina M,Watanabe M,Lipton SA,Nakanishi N,Pérez-Otaño I,Weinberg RJ,Philpot BD

更新日期：2011-03-01 00:00:00

abstract：:The excitability of individual dendritic branches is a plastic property of neurons. We found that experience in an enriched environment increased propagation of dendritic Na(+) spikes in a subset of individual dendritic branches in rat hippocampal CA1 pyramidal neurons and that this effect was mainly mediated by local...

journal_title：Nature neuroscience

authors： Makara JK,Losonczy A,Wen Q,Magee JC

更新日期：2009-12-01 00:00:00

abstract：:The melanocortin system provides a conceptual blueprint for the central control of energetic state. Defined by four principal molecular components--two antagonistically acting ligands and two cognate receptors--this phylogenetically conserved system serves as a prototype for hierarchical energy balance regulation. Ove...

journal_title：Nature neuroscience

authors： Krashes MJ,Lowell BB,Garfield AS

更新日期：2016-02-01 00:00:00

abstract：:Images are processed in the primary visual cortex by neurons that encode different stimulus orientations and spatial phases. In primates and carnivores, neighboring cortical neurons share similar orientation preferences, but spatial phases were thought to be randomly distributed. We discovered a columnar organization ...

journal_title：Nature neuroscience

authors： Wang Y,Jin J,Kremkow J,Lashgari R,Komban SJ,Alonso JM

更新日期：2015-01-01 00:00:00

abstract：:Neocortical GABAergic neurons have diverse molecular, structural and electrophysiological features, but the functional correlates of this diversity are largely unknown. We found unique membrane potential dynamics of somatostatin-expressing (SOM) neurons in layer 2/3 of the primary somatosensory barrel cortex of awake ...

journal_title：Nature neuroscience

authors： Gentet LJ,Kremer Y,Taniguchi H,Huang ZJ,Staiger JF,Petersen CC

更新日期：2012-02-26 00:00:00

abstract：:Specialization and hierarchy are organizing principles for primate cortex, yet there is little direct evidence for how cortical areas are specialized in the temporal domain. We measured timescales of intrinsic fluctuations in spiking activity across areas and found a hierarchical ordering, with sensory and prefrontal ...

journal_title：Nature neuroscience

authors： Murray JD,Bernacchia A,Freedman DJ,Romo R,Wallis JD,Cai X,Padoa-Schioppa C,Pasternak T,Seo H,Lee D,Wang XJ

更新日期：2014-12-01 00:00:00

abstract：:Independent evidence associates β-amyloid pathology with both non-rapid eye movement (NREM) sleep disruption and memory impairment in older adults. However, whether the influence of β-amyloid pathology on hippocampus-dependent memory is, in part, driven by impairments of NREM slow wave activity (SWA) and associated ov...

journal_title：Nature neuroscience

authors： Mander BA,Marks SM,Vogel JW,Rao V,Lu B,Saletin JM,Ancoli-Israel S,Jagust WJ,Walker MP

更新日期：2015-07-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs), negative regulators of neural determination in the early embryo, were found to be potent inhibitors of neurogenesis in olfactory epithelium (OE) cultures. BMPs 2, 4 or 7 decreased the number of proliferating progenitor cells and blocked production of olfactory receptor neurons (ORNs...

journal_title：Nature neuroscience

authors： Shou J,Rim PC,Calof AL

更新日期：1999-04-01 00:00:00

abstract：:Uncovering structural regularities and architectural topologies of cortical circuitry is vital for understanding neural computations. Recently, an experimentally constrained algorithm generated a dense network reconstruction of a ∼0.3-mm3 volume from juvenile rat somatosensory neocortex, comprising ∼31,000 cells and ∼...

journal_title：Nature neuroscience

authors： Gal E,London M,Globerson A,Ramaswamy S,Reimann MW,Muller E,Markram H,Segev I

更新日期：2017-07-01 00:00:00

abstract：:Visual attention enhances the responses of visual neurons that encode the attended location. Several recent studies have shown that attention also decreases correlations between fluctuations in the responses of pairs of neurons (termed spike count correlation or r(SC)). These results are consistent with two hypotheses...

journal_title：Nature neuroscience

authors： Ruff DA,Cohen MR

更新日期：2014-11-01 00:00:00

abstract：:Processing of rapidly successive acoustic stimuli can be markedly improved by sensory training. To investigate the cortical mechanisms underlying such temporal plasticity, we trained rats in a 'sound maze' in which navigation using only auditory cues led to a target location paired with food reward. In this task, the ...

journal_title：Nature neuroscience

authors： Bao S,Chang EF,Woods J,Merzenich MM

更新日期：2004-09-01 00:00:00

abstract：:Cerebellar abnormalities, particularly in Right Crus I (RCrusI), are consistently reported in autism spectrum disorders (ASD). Although RCrusI is functionally connected with ASD-implicated circuits, the contribution of RCrusI dysfunction to ASD remains unclear. Here neuromodulation of RCrusI in neurotypical humans res...

journal_title：Nature neuroscience

authors： Stoodley CJ,D'Mello AM,Ellegood J,Jakkamsetti V,Liu P,Nebel MB,Gibson JM,Kelly E,Meng F,Cano CA,Pascual JM,Mostofsky SH,Lerch JP,Tsai PT

更新日期：2017-12-01 00:00:00

abstract：:Phagocytic cell NADPH oxidase (NOX) generates reactive oxygen species (ROS) as part of innate immunity. Unfortunately, ischemia can also induce this pathway and inflict damage on native cells. The voltage-gated proton channel Hv1 enables NOX function by compensating cellular loss of electrons with protons. Accordingly...

journal_title：Nature neuroscience

authors： Wu LJ,Wu G,Akhavan Sharif MR,Baker A,Jia Y,Fahey FH,Luo HR,Feener EP,Clapham DE

更新日期：2012-03-04 00:00:00

abstract：:In the published version of this article, a data point is missing from Fig. 4f, and the y-axis label reads "RFpre"; it should read "RFpref." The original article has not been corrected. The original and corrected figures are shown in the accompanying Publisher Correction. ...

journal_title：Nature neuroscience

authors： Lien AD,Scanziani M

更新日期：2018-09-01 00:00:00

abstract：:Nature Neuroscience presents a special issue of recent advances on shared mechanisms underlying neurodegenerative disease. ...

journal_title：Nature neuroscience

authors：

更新日期：2018-10-01 00:00:00

abstract：:The molecular organization of presynaptic active zones is important for the neurotransmitter release that is triggered by depolarization-induced Ca2+ influx. Here, we demonstrate a previously unknown interaction between two components of the presynaptic active zone, RIM1 and voltage-dependent Ca2+ channels (VDCCs), th...

journal_title：Nature neuroscience

authors： Kiyonaka S,Wakamori M,Miki T,Uriu Y,Nonaka M,Bito H,Beedle AM,Mori E,Hara Y,De Waard M,Kanagawa M,Itakura M,Takahashi M,Campbell KP,Mori Y

更新日期：2007-06-01 00:00:00

abstract：:The accessory olfactory bulb (AOB) is a critical olfactory structure that has been implicated in mediating social behavior. It receives input from the vomeronasal organ and projects to targets in the amygdaloid complex. Its anterior and posterior components (aAOB and pAOB) display molecular, connectional and functiona...

journal_title：Nature neuroscience

authors： Huilgol D,Udin S,Shimogori T,Saha B,Roy A,Aizawa S,Hevner RF,Meyer G,Ohshima T,Pleasure SJ,Zhao Y,Tole S

更新日期：2013-02-01 00:00:00

abstract：:Adult neurogenesis occurs in the hippocampus and the olfactory bulb of the mammalian CNS. Recent studies have demonstrated that newborn granule cells of the adult hippocampus are postsynaptic targets of excitatory and inhibitory neurons, but evidence of synapse formation by the axons of these cells is still lacking. B...

journal_title：Nature neuroscience

authors： Toni N,Laplagne DA,Zhao C,Lombardi G,Ribak CE,Gage FH,Schinder AF

更新日期：2008-08-01 00:00:00

abstract：:Replay of hippocampal place cell sequences has been proposed as a fundamental mechanism of learning and memory. However, the standard interpretation of replay has been challenged by reports that similar activity is observed before experience ('preplay'). By the preplay account, pre-existing temporal sequences are mapp...

journal_title：Nature neuroscience

authors： Silva D,Feng T,Foster DJ

更新日期：2015-12-01 00:00:00

abstract：:We studied the febrile response in mice deficient in microsomal prostaglandin E synthase-1 (mPGES-1), an inducible terminal isomerase expressed in cytokine-sensitive brain endothelial cells. These animals showed no fever and no central prostaglandin (PG) E2 synthesis after peripheral injection of bacterial-wall lipopo...

journal_title：Nature neuroscience

authors： Engblom D,Saha S,Engström L,Westman M,Audoly LP,Jakobsson PJ,Blomqvist A

更新日期：2003-11-01 00:00:00

abstract：:Axon degeneration is a hallmark of many neurodegenerative disorders. The current assumption is that the decision of injured axons to degenerate is cell-autonomously regulated. Here we show that Schwann cells (SCs), the glia of the peripheral nervous system, protect injured axons by virtue of a dramatic glycolytic upre...

journal_title：Nature neuroscience

authors： Babetto E,Wong KM,Beirowski B

更新日期：2020-10-01 00:00:00