Correlating whisker behavior with membrane potential in barrel cortex of awake mice.

abstract：:Exposure to a stressor sensitizes behavioral and hormonal responses to future stressors. Stress-associated release of noradrenaline enhances the capacity of central synapses to show plasticity (metaplasticity). We found noradrenaline-dependent metaplasticity at GABA synapses in the paraventricular nucleus of the hypot...

journal_title：Nature neuroscience

authors： Inoue W,Baimoukhametova DV,Füzesi T,Wamsteeker Cusulin JI,Koblinger K,Whelan PJ,Pittman QJ,Bains JS

更新日期：2013-05-01 00:00:00

abstract：:Cue-triggered recall of learned temporal sequences is an important cognitive function that has been attributed to higher brain areas. Here recordings in both anesthetized and awake rats demonstrate that after repeated stimulation with a moving spot that evoked sequential firing of an ensemble of primary visual cortex ...

journal_title：Nature neuroscience

authors： Xu S,Jiang W,Poo MM,Dan Y

更新日期：2012-01-22 00:00:00

abstract：:Changes in spine morphology may underlie memory formation, but the molecular mechanisms that subserve such alterations are poorly understood. Here we show that fear conditioning in rats leads to the movement of profilin, an actin polymerization-regulatory protein, into dendritic spines in the lateral amygdala and that...

journal_title：Nature neuroscience

authors： Lamprecht R,Farb CR,Rodrigues SM,LeDoux JE

更新日期：2006-04-01 00:00:00

abstract：:We found that K(+)/Cl(-) co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn(2+), a major component of neuronal injury. Zn(2+)-mediated KCC2 inhibition produced a depolarizing shift of GABA(A) reversal potentials in rat cortical neurons. Moreover, oxygen-glucose ...

journal_title：Nature neuroscience

authors： Hershfinkel M,Kandler K,Knoch ME,Dagan-Rabin M,Aras MA,Abramovitch-Dahan C,Sekler I,Aizenman E

更新日期：2009-06-01 00:00:00

abstract：:Peptides derived from proteolytic processing of the beta-amyloid precursor protein (APP), including the amyloid-beta peptide, are important for the pathogenesis of Alzheimer's dementia. We found that transgenic mice overexpressing APP have a profound and selective impairment in endothelium-dependent regulation of the ...

journal_title：Nature neuroscience

authors： Iadecola C,Zhang F,Niwa K,Eckman C,Turner SK,Fischer E,Younkin S,Borchelt DR,Hsiao KK,Carlson GA

更新日期：1999-02-01 00:00:00

abstract：:The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligoden...

journal_title：Nature neuroscience

authors： Goebbels S,Wieser GL,Pieper A,Spitzer S,Weege B,Yan K,Edgar JM,Yagensky O,Wichert SP,Agarwal A,Karram K,Renier N,Tessier-Lavigne M,Rossner MJ,Káradóttir RT,Nave KA

更新日期：2017-01-01 00:00:00

abstract：:Individuals' risk attitudes are known to guide choices about uncertain options. However, in the presence of others' decisions, these choices can be swayed and manifest as riskier or safer behavior than one would express alone. To test the mechanisms underlying effective social 'nudges' in human decision-making, we use...

journal_title：Nature neuroscience

authors： Chung D,Christopoulos GI,King-Casas B,Ball SB,Chiu PH

更新日期：2015-06-01 00:00:00

abstract：:Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood. Here we investigated the neuronal pathways for itch neurotransmission, particularly the contribution of the neuropeptide ...

journal_title：Nature neuroscience

authors： Huang J,Polgár E,Solinski HJ,Mishra SK,Tseng PY,Iwagaki N,Boyle KA,Dickie AC,Kriegbaum MC,Wildner H,Zeilhofer HU,Watanabe M,Riddell JS,Todd AJ,Hoon MA

更新日期：2018-05-01 00:00:00

abstract：:The music faculty is not a monolithic entity that a person either has or does not. Rather, it comprises a set of neurally isolable processing components, each having the potential to be specialized for music. Here we propose a functional architecture for music processing that captures the typical properties of modular...

journal_title：Nature neuroscience

authors： Peretz I,Coltheart M

更新日期：2003-07-01 00:00:00

abstract：:Laboratory models, including animal tissues and live animals, have proven useful for discovery of molecular targets of alcohol action as well as for characterization of genetic and environmental factors that influence alcohol's neural actions. Here we consider strengths and weaknesses of laboratory models used in alco...

journal_title：Nature neuroscience

authors： Lovinger DM,Crabbe JC

更新日期：2005-11-01 00:00:00

abstract：:Dendritic spines undergo actin-based growth and shrinkage during synaptic plasticity, in which the actin depolymerizing factor (ADF)/cofilin family of actin-associated proteins are important. Elevated ADF/cofilin activities often lead to reduced spine size and immature spine morphology but can also enhance synaptic po...

journal_title：Nature neuroscience

authors： Gu J,Lee CW,Fan Y,Komlos D,Tang X,Sun C,Yu K,Hartzell HC,Chen G,Bamburg JR,Zheng JQ

更新日期：2010-10-01 00:00:00

abstract：:Temporal regulation of embryonic neurogenesis is controlled by hypostable transcription factors. The mechanism of the process is unclear. Here we show that the RNase III Drosha and DGCR8 (also known as Pasha), key components of the microRNA (miRNA) microprocessor, have important functions in mouse neurogenesis. Loss o...

journal_title：Nature neuroscience

authors： Knuckles P,Vogt MA,Lugert S,Milo M,Chong MM,Hautbergue GM,Wilson SA,Littman DR,Taylor V

更新日期：2012-06-17 00:00:00

abstract：:The mechanism by which adult neural stem cells (NSCs) are established during development is unclear. In this study, analysis of cell cycle progression by examining retention of a histone 2B (H2B)-GFP fusion protein revealed that, in a subset of mouse embryonic neural progenitor cells (NPCs), the cell cycle slows betwe...

journal_title：Nature neuroscience

authors： Furutachi S,Miya H,Watanabe T,Kawai H,Yamasaki N,Harada Y,Imayoshi I,Nelson M,Nakayama KI,Hirabayashi Y,Gotoh Y

更新日期：2015-05-01 00:00:00

abstract：:Previous work has shown that human adolescents may be hypersensitive to rewards, but it is not known which aspect of reward processing is responsible for this. We separated decision value and prediction error signals and found that neural prediction error signals in the striatum peaked in adolescence, whereas neural d...

journal_title：Nature neuroscience

authors： Cohen JR,Asarnow RF,Sabb FW,Bilder RM,Bookheimer SY,Knowlton BJ,Poldrack RA

更新日期：2010-06-01 00:00:00

abstract：:Memory reconsolidation has been demonstrated in various tasks and species, suggesting it is a fundamental process. However, there are experimental parameters that can inhibit reconsolidation from occurring (boundary conditions). These conditions and their mechanisms remain poorly defined. Here, we characterize the abi...

journal_title：Nature neuroscience

authors： Wang SH,de Oliveira Alvares L,Nader K

更新日期：2009-07-01 00:00:00

abstract：:Transformation of mechanical energy into ionic currents is essential for touch, hearing and nociception. Although DEG/ENaC proteins are believed to form sensory mechanotransduction channels, the evidence for this role remains indirect. By recording from C. elegans touch receptor neurons in vivo, we found that external...

journal_title：Nature neuroscience

authors： O'Hagan R,Chalfie M,Goodman MB

更新日期：2005-01-01 00:00:00

abstract：:The brain transforms physical sensory stimuli into meaningful perceptions. In animals making choices about sensory stimuli, neuronal activity in successive cortical stages reflects a progression from sensation to decision. Feedforward and feedback pathways connecting cortical areas are critical for this transformation...

journal_title：Nature neuroscience

authors： Kwon SE,Yang H,Minamisawa G,O'Connor DH

更新日期：2016-09-01 00:00:00

abstract：:Synaptic cadherin adhesion complexes are known to be key regulators of synapse plasticity. However, the molecular mechanisms that coordinate activity-induced modifications in cadherin localization and adhesion and the subsequent changes in synapse morphology and efficacy remain unknown. We demonstrate that the intrace...

journal_title：Nature neuroscience

authors： Brigidi GS,Sun Y,Beccano-Kelly D,Pitman K,Mobasser M,Borgland SL,Milnerwood AJ,Bamji SX

更新日期：2014-04-01 00:00:00

abstract：:It is often assumed that all neurons of the same cell type have identical intrinsic properties, both within an animal and between animals. We exploited the large size and small number of unambiguously identifiable neurons in the crab stomatogastric ganglion to test this assumption at the level of channel mRNA expressi...

journal_title：Nature neuroscience

authors： Schulz DJ,Goaillard JM,Marder E

更新日期：2006-03-01 00:00:00

abstract：:Although inherently linked, body form and body action may be represented in separate neural substrates. Using repetitive transcranial magnetic stimulation in healthy individuals, we show that interference with the extrastriate body area impairs the discrimination of bodily forms, and interference with the ventral prem...

journal_title：Nature neuroscience

authors： Urgesi C,Candidi M,Ionta S,Aglioti SM

更新日期：2007-01-01 00:00:00

abstract：:The neurotransmitter acetylcholine (ACh) has a crucial role in central and neuromuscular synapses of the cholinergic system. After release into the synaptic cleft, ACh is rapidly degraded by acetylcholinesterase (AChE). We have identified a mutation in the ache gene of the zebrafish, which abolishes ACh hydrolysis in ...

journal_title：Nature neuroscience

authors： Behra M,Cousin X,Bertrand C,Vonesch JL,Biellmann D,Chatonnet A,Strähle U

更新日期：2002-02-01 00:00:00

abstract：:Very little is known about how stimuli that are typically not rich in sugars, such as beer, trigger attractive gustatory responses in Drosophila. We identified a member of the gustatory receptor family, Gr64e, as a receptor that is required for feeding preference for beer and other sources that have fermenting yeast. ...

journal_title：Nature neuroscience

authors： Wisotsky Z,Medina A,Freeman E,Dahanukar A

更新日期：2011-11-06 00:00:00

abstract：:An unresolved question in neuroscience relates to the extent to which corticothalamocortical circuits emanating from layer 5B are involved in information transfer through the cortical hierarchy. Using a new form of optical imaging in a brain slice preparation, we found that the corticothalamocortical pathway drove rob...

journal_title：Nature neuroscience

authors： Theyel BB,Llano DA,Sherman SM

更新日期：2010-01-01 00:00:00

abstract：:A brief visual target stimulus may be rendered invisible if it is immediately preceded or followed by another stimulus. This class of illusions, known as visual masking, may allow insights into the neural mechanisms that underlie visual perception. We have therefore explored the temporal characteristics of masking ill...

journal_title：Nature neuroscience

authors： Macknik SL,Livingstone MS

更新日期：1998-06-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease whose causes are still poorly understood. To identify additional genetic risk factors, we assessed the role of de novo mutations in ALS by sequencing the exomes of 47 ALS patients and both of their unaffected parents (n = 141 exomes). We fo...

journal_title：Nature neuroscience

authors： Chesi A,Staahl BT,Jovičić A,Couthouis J,Fasolino M,Raphael AR,Yamazaki T,Elias L,Polak M,Kelly C,Williams KL,Fifita JA,Maragakis NJ,Nicholson GA,King OD,Reed R,Crabtree GR,Blair IP,Glass JD,Gitler AD

更新日期：2013-07-01 00:00:00

abstract：:Arcuate nucleus (ARC) neurons sense the fed or fasted state and regulate hunger. Agouti-related protein (AgRP) neurons in the ARC (ARCAgRP neurons) are stimulated by fasting and, once activated, they rapidly (within minutes) drive hunger. Pro-opiomelanocortin (ARCPOMC) neurons are viewed as the counterpoint to ARCAgRP...

journal_title：Nature neuroscience

authors： Fenselau H,Campbell JN,Verstegen AM,Madara JC,Xu J,Shah BP,Resch JM,Yang Z,Mandelblat-Cerf Y,Livneh Y,Lowell BB

更新日期：2017-01-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature neuroscience

authors： Mongillo G,Rumpel S,Loewenstein Y

更新日期：2019-12-01 00:00:00

abstract：:The molecular basis of CNS myelin regeneration (remyelination) is poorly understood. We generated a comprehensive transcriptional profile of the separate stages of spontaneous remyelination that follow focal demyelination in the rat CNS and found that transcripts that encode the retinoid acid receptor RXR-γ were diffe...

journal_title：Nature neuroscience

authors： Huang JK,Jarjour AA,Nait Oumesmar B,Kerninon C,Williams A,Krezel W,Kagechika H,Bauer J,Zhao C,Baron-Van Evercooren A,Chambon P,Ffrench-Constant C,Franklin RJM

更新日期：2011-01-01 00:00:00

abstract：:Neural stem and progenitor cells (NSCs/NPCs) give rise to neurons, astrocytes and oligodendrocytes. However, the mechanisms underlying the decision of a stem cell to either self-renew or differentiate are incompletely understood. We demonstrate here that Fbw7 (F-box and WD repeat domain containing-7), the substrate re...

journal_title：Nature neuroscience

authors： Hoeck JD,Jandke A,Blake SM,Nye E,Spencer-Dene B,Brandner S,Behrens A

更新日期：2010-11-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature neuroscience

authors： Farhan SMK,Howrigan DP,Abbott LE,Klim JR,Topp SD,Byrnes AE,Churchhouse C,Phatnani H,Smith BN,Rampersaud E,Wu G,Wuu J,Shatunov A,Iacoangeli A,Khleifat AA,Mordes DA,Ghosh S,ALSGENS Consortium.,FALS Consortium.,Project

更新日期：2020-02-01 00:00:00