Abstract：
:Recent imaging studies show that the formation of neural connections in the central nervous system is a highly dynamic process. The iterative formation and elimination of synapses and neuronal branches result in the formation of a much larger number of trial connections than is maintained in the mature brain. Neural activity modulates development through biasing this process of formation and elimination, promoting the formation and stabilization of appropriate synaptic connections on the basis of functional activity patterns.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Hua JY,Smith SJdoi
10.1038/nn1218subject
Has Abstractpub_date
2004-04-01 00:00:00pages
327-32issue
4eissn
1097-6256issn
1546-1726pii
nn1218journal_volume
7pub_type
杂志文章,评审abstract：:The dorsal root ganglia (DRG) contain a variety of mechanoreceptors, but no molecular markers uniquely identify specific mechanoreceptor subtypes. We have used DNA microarrays and subtracted cDNA libraries to isolate genes that are specifically expressed by one type of mouse mechanoreceptor. The T-type calcium channel...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1076
更新日期：2003-07-01 00:00:00
abstract：:Every year in the United States, an estimated 500,000 babies are born preterm (before 37 completed weeks of gestation), and this number is rising, along with the recognition of brain injuries due to preterm delivery. A common underlying pathogenesis appears to be perinatal hypoxia induced by immature lung development,...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.3604
更新日期：2014-03-01 00:00:00
abstract：:Loss of noradrenergic locus coeruleus (LC) neurons is a prominent feature of aging-related neurodegenerative diseases, such as Parkinson's disease (PD). The basis of this vulnerability is not understood. To explore possible physiological determinants, we studied LC neurons using electrophysiological and optical approa...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3717
更新日期：2014-06-01 00:00:00
abstract：:Human observers adapted to complex biological motions that distinguish males from females: viewing the gait of one gender biased judgments of subsequent gaits toward the opposite gender. This adaptation was not simply due to local features of the stimuli but instead relied upon the global motion of the figures. These ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1710
更新日期：2006-06-01 00:00:00
abstract：:Calcium arising through release from intracellular stores and from influx across the plasma membrane is essential for signalling by specific guidance cues and by factors that inhibit axon regeneration. The mediators of calcium influx in these cases are largely unknown. Transient receptor potential channels (TRPCs) bel...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1459
更新日期：2005-06-01 00:00:00
abstract：:The hippocampus is thought to be involved in episodic memory formation by reactivating traces of waking experience during sleep. Indeed, the joint firing of spatially tuned pyramidal cells encoding nearby places recur during sleep. We found that the sleep cofiring of rat CA1 pyramidal cells encoding similar places inc...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn2037
更新日期：2008-02-01 00:00:00
abstract：:Midbrain ventral tegmental neurons project to the prefrontal cortex and modulate cognitive functions. Using viral tracing, optogenetics and electrophysiology, we found that mesocortical neurons in the mouse ventrotegmental area provide fast glutamatergic excitation of GABAergic interneurons in the prefrontal cortex an...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4020
更新日期：2015-06-01 00:00:00
abstract：:Sensory neural systems use spatiotemporal coding mechanisms to represent stimuli. These time-varying response patterns sometimes outlast the stimulus. Can the temporal structure of a stimulus interfere with, or even disrupt, the spatiotemporal structure of the neural representation? We investigated this potential conf...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1559
更新日期：2005-11-01 00:00:00
abstract：:We investigated the regulation of T-type channels by Rho-associated kinase (ROCK). Activation of ROCK via the endogenous ligand lysophosphatidic acid (LPA) reversibly inhibited the peak current amplitudes of rat Ca(v)3.1 and Ca(v)3.3 channels without affecting the voltage dependence of activation or inactivation, wher...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1921
更新日期：2007-07-01 00:00:00
abstract：:Cognition can be conceptualized as a set of algorithmic control functions whose real-time deployment determines how an organism stores and uses information to guide thought and action. A subset of these functions is required for goal-directed selection and amplification of sensory signals-broadly referred to as attent...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/s41593-017-0020-1
更新日期：2017-12-01 00:00:00
abstract：:Sleep can strengthen memory for emotional information, but whether emotional memories can be specifically targeted and modified during sleep is unknown. In human subjects who underwent olfactory contextual fear conditioning, re-exposure to the odorant context in slow-wave sleep promoted stimulus-specific fear extincti...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3527
更新日期：2013-11-01 00:00:00
abstract：:Illusions that produce perceptual suppression despite constant retinal input are used to manipulate visual consciousness. Here we report on a powerful variant of existing techniques, continuous flash suppression. Distinct images flashed successively at approximately 10 Hz into one eye reliably suppress an image presen...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1500
更新日期：2005-08-01 00:00:00
abstract：:Entorhinal grid cells in mammals fire as a function of animal location, with spatially periodic response patterns. This nonlocal periodic representation of location, a local variable, is unlike other neural codes. There is no theoretical explanation for why such a code should exist. We examined how accurately the grid...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2901
更新日期：2011-09-11 00:00:00
abstract：:Dendritic spines undergo actin-based growth and shrinkage during synaptic plasticity, in which the actin depolymerizing factor (ADF)/cofilin family of actin-associated proteins are important. Elevated ADF/cofilin activities often lead to reduced spine size and immature spine morphology but can also enhance synaptic po...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2634
更新日期：2010-10-01 00:00:00
abstract：:Angelman syndrome (AS) is a severe neurological disorder characterized by mental retardation, motor dysfunction and epilepsy. We show that the molecular and cellular deficits of an AS mouse model can be rescued by introducing an additional mutation at the inhibitory phosphorylation site of alphaCaMKII. Moreover, these...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1845
更新日期：2007-03-01 00:00:00
abstract：:Breathing is a bilaterally synchronous behavior that relies on a respiratory rhythm generator located in the brainstem. An essential component of this generator is the preBötzinger complex (preBötC), which paces inspirations. Little is known about the developmental origin of the interneuronal populations forming the p...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2622
更新日期：2010-09-01 00:00:00
abstract：:Three families of ligand-activated ion channels mediate synaptic communication between excitable cells in mammals. For pentameric channels related to nicotinic acetylcholine receptors and tetrameric channels such as glutamate receptors, the pore-forming and gate regions have been studied extensively. In contrast, litt...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2151
更新日期：2008-08-01 00:00:00
abstract：:Dopamine (DA) D2 receptors expressed in DA neurons (D2 autoreceptors) exert a negative feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D2 receptors are mostly expressed in postsynaptic neurons, pharmacological and genetic approaches have been unable to definitively address the in viv...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2862
更新日期：2011-07-10 00:00:00
abstract：:The ability to attribute mental states to others, and therefore to predict others' behavior, is particularly advanced in humans. A controversial but untested idea is that this is achieved by simulating the other person's mental processes in one's own mind. If this is the case, then the same neural systems activated by...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1168
更新日期：2004-01-01 00:00:00
abstract：:Electrical stimulation of visual cortex can produce a visual percept (phosphene). We electrically stimulated visual cortex in humans implanted with subdural electrodes while recording from other brain sites. Phosphene perception occurred only if stimulation evoked high-frequency gamma oscillations in the temporopariet...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3131
更新日期：2012-06-03 00:00:00
abstract：:The C. elegans SAX-3/Robo receptor acts in anterior-posterior, dorsal-ventral and midline guidance decisions. Here we show that SAX-3 signaling involves the C. elegans Enabled protein UNC-34 and an unexpected Netrin-independent function of the Netrin receptor UNC-40/DCC. Genetic interactions with gain- and loss-of-fun...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn956
更新日期：2002-11-01 00:00:00
abstract：:Interleukin 17 (IL-17) is a signature cytokine of Th17 cells. We previously reported that deletion of NF-κB activator 1 (Act1), the key transducer of IL-17 receptor signaling, from the neuroectodermal lineage in mice (neurons, oligodendrocytes and astrocytes) results in attenuated severity of experimental autoimmune e...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3505
更新日期：2013-10-01 00:00:00
abstract：:High and low spatial frequency information in visual images is processed by distinct neural channels. Using event-related functional magnetic resonance imaging (fMRI) in humans, we show dissociable roles of such visual channels for processing faces and emotional fearful expressions. Neural responses in fusiform cortex...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1057
更新日期：2003-06-01 00:00:00
abstract：:Processing of rapidly successive acoustic stimuli can be markedly improved by sensory training. To investigate the cortical mechanisms underlying such temporal plasticity, we trained rats in a 'sound maze' in which navigation using only auditory cues led to a target location paired with food reward. In this task, the ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1293
更新日期：2004-09-01 00:00:00
abstract：:Transformation of mechanical energy into ionic currents is essential for touch, hearing and nociception. Although DEG/ENaC proteins are believed to form sensory mechanotransduction channels, the evidence for this role remains indirect. By recording from C. elegans touch receptor neurons in vivo, we found that external...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1362
更新日期：2005-01-01 00:00:00
abstract：:The shift in ocular dominance induced by brief monocular deprivation is greatest during a postnatal critical period and is thought to decline irreversibly thereafter. However, here we demonstrate that complete visual deprivation through dark exposure restores rapid ocular dominance plasticity in adult rats. In additio...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1965
更新日期：2007-09-01 00:00:00
abstract：:Synaptic stimulation activates signal transduction pathways, producing persistently active protein kinases. PKMzeta is a truncated, persistently active isoform of atypical protein kinase C-zeta (aPKCzeta), which lacks the N-terminal pseudosubstrate regulatory domain. Using a Pavlovian olfactory learning task in Drosop...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn820
更新日期：2002-04-01 00:00:00
abstract：:As we move through the environment, the pattern of visual motion on the retina provides rich information about our movement through the scene. Human subjects can use this information, often termed "optic flow", to accurately estimate their direction of self movement (heading) from relatively sparse displays. Physiolog...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/259
更新日期：1998-05-01 00:00:00
abstract：:The hypothalamus contains the highest diversity of neurons in the brain. Many of these neurons can co-release neurotransmitters and neuropeptides in a use-dependent manner. Investigators have hitherto relied on candidate protein-based tools to correlate behavioral, endocrine and gender traits with hypothalamic neuron ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4462
更新日期：2017-02-01 00:00:00
abstract：:The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligoden...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4425
更新日期：2017-01-01 00:00:00
