Abstract：
:The development of neuronal networks in the neocortex depends on control mechanisms for mitosis and migration that allow newborn neurons to find their accurate position. Multiple mitogens, neurotrophic factors, guidance molecules and their corresponding receptors are involved in this process, but the mechanisms by which these signals are integrated are only poorly understood. We found that TrkB and TrkC, the receptors for brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), are activated by epidermal growth factor receptor (EGFR) signaling rather than by BDNF or NT-3 in embryonic mouse cortical precursor cells. This transactivation event regulated migration of early neuronal cells to their final position in the developing cortex. Transactivation by EGF led to membrane translocation of TrkB, promoting its signaling responsiveness. Our results provide genetic evidence that TrkB and TrkC activation in early cortical neurons do not depend on BDNF and NT-3, but instead on transactivation by EGFR signaling.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Puehringer D,Orel N,Lüningschrör P,Subramanian N,Herrmann T,Chao MV,Sendtner Mdoi
10.1038/nn.3333subject
Has Abstractpub_date
2013-04-01 00:00:00pages
407-15issue
4eissn
1097-6256issn
1546-1726pii
nn.3333journal_volume
16pub_type
杂志文章abstract：:Hippocampal replay during sharp-wave ripple events (SWRs) is thought to drive memory consolidation in hippocampal and cortical circuits. Changes in neocortical activity can precede SWR events, but whether and how these changes influence the content of replay remains unknown. Here we show that during sleep there is a r...
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更新日期：2011-11-13 00:00:00
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更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/nn.2249
更新日期：2009-02-01 00:00:00
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更新日期：2017-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/nn.2146
更新日期：2008-07-01 00:00:00
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doi：10.1038/nn.2923
更新日期：2011-09-27 00:00:00
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pub_type： 杂志文章
doi：10.1038/nn.4313
更新日期：2016-07-01 00:00:00
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doi：10.1038/nn935
更新日期：2002-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/nn.3772
更新日期：2014-09-01 00:00:00
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