Abstract：
:Some neurons in auditory cortex respond to recent stimulus history by adapting their response functions to track stimulus statistics directly, as might be expected. In contrast, some neurons respond to loud sounds by adjusting their response functions away from high intensities and consequently remain sensitive to softer sounds. In marmoset monkey auditory cortex, the latter type of adaptation appears to exist only in neurons tuned to stimulus intensity.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Watkins PV,Barbour DLdoi
10.1038/nn.2201subject
Has Abstractpub_date
2008-11-01 00:00:00pages
1259-61issue
11eissn
1097-6256issn
1546-1726pii
nn.2201journal_volume
11pub_type
杂志文章abstract：:The melanocortin system provides a conceptual blueprint for the central control of energetic state. Defined by four principal molecular components--two antagonistically acting ligands and two cognate receptors--this phylogenetically conserved system serves as a prototype for hierarchical energy balance regulation. Ove...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.4202
更新日期：2016-02-01 00:00:00
abstract：:Very little is known about how stimuli that are typically not rich in sugars, such as beer, trigger attractive gustatory responses in Drosophila. We identified a member of the gustatory receptor family, Gr64e, as a receptor that is required for feeding preference for beer and other sources that have fermenting yeast. ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2944
更新日期：2011-11-06 00:00:00
abstract：:Neuronal activity-induced gene expression modulates the function and plasticity of the nervous system. It is unknown whether and to what extent neuronal activity may trigger changes in chromatin accessibility, a major mode of epigenetic regulation of gene expression. Here we compared chromatin accessibility landscapes...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4494
更新日期：2017-03-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-020-00710-7
更新日期：2020-11-01 00:00:00
abstract：:In the version of this article initially published, the traces in Fig. 1j and in Fig. 1k, right, were duplicated from the corresponding traces in Fig. 1c, bottom, and Fig. 1d, bottom right. The error has been corrected in the HTML and PDF versions of the article. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-018-0183-4
更新日期：2018-09-01 00:00:00
abstract：:Information analysis shows that face-selective neurons in inferior temporal cortex encode different stimulus attributes early and late in their response to the same image. ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/13149
更新日期：1999-10-01 00:00:00
abstract：:Brain tumor initiating cells (BTICs) co-opt the neuronal high affinity glucose transporter, GLUT3, to withstand metabolic stress. We investigated another mechanism critical to brain metabolism, mitochondrial morphology, in BTICs. BTIC mitochondria were fragmented relative to non-BTIC tumor cell mitochondria, suggestin...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3960
更新日期：2015-04-01 00:00:00
abstract：:Although it has long been known that cultured embryonic stem cells can generate neurons, the lineage relationships with their immediate precursors remain unclear. We report here that selection of highly proliferative stem cells followed by treatment with retinoic acid generated essentially pure precursors that markers...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1301
更新日期：2004-09-01 00:00:00
abstract：:We studied how the posterior parietal cortex combines new information with ongoing activity dynamics as mice accumulate evidence during a virtual navigation task. Using new methods to analyze population activity on single trials, we found that activity transitioned rapidly between different sets of active neurons. Eac...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4403
更新日期：2016-12-01 00:00:00
abstract：:Histone deacetylases (HDACs) are major epigenetic regulators. We show that HDAC1 and HDAC2 functions are critical for myelination of the peripheral nervous system. Using mouse genetics, we have ablated Hdac1 and Hdac2 specifically in Schwann cells, resulting in massive Schwann cell loss and virtual absence of myelin i...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2762
更新日期：2011-04-01 00:00:00
abstract：:It is often assumed that all neurons of the same cell type have identical intrinsic properties, both within an animal and between animals. We exploited the large size and small number of unambiguously identifiable neurons in the crab stomatogastric ganglion to test this assumption at the level of channel mRNA expressi...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1639
更新日期：2006-03-01 00:00:00
abstract：:The specification of area identities in the cerebral cortex is a complex process, primed by intrinsic cortical cues and refined after the arrival of afferent fibers from the thalamus. Little is known about the genetic control of the early steps of this process, but the distinctive expression pattern of the homeogene E...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/76630
更新日期：2000-07-01 00:00:00
abstract：:Much of the information processing in the brain occurs at the level of local circuits; however, the mechanisms underlying their initial development are poorly understood. We sought to examine the early development and plasticity of local excitatory circuits in the optic tectum of Xenopus laevis tadpoles. We found that...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn2076
更新日期：2008-04-01 00:00:00
abstract：:Ongoing sensory input is critical for shaping internal representations of the external world. Conversely, a lack of sensory input can profoundly perturb the formation of these representations. The olfactory system is particularly vulnerable to sensory deprivation, owing to the widespread prevalence of allergic, viral ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3186
更新日期：2012-09-01 00:00:00
abstract：:Sharp wave-associated field oscillations (∼200 Hz) of the hippocampus, referred to as ripples, are believed to be important for consolidation of explicit memory. Little is known about how ripples are regulated by other brain regions. We found that the median raphe region (MnR) is important for regulating hippocampal r...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3998
更新日期：2015-05-01 00:00:00
abstract：:A decade after speech was first decoded from human brain signals, accuracy and speed remain far below that of natural speech. Here we show how to decode the electrocorticogram with high accuracy and at natural-speech rates. Taking a cue from recent advances in machine translation, we train a recurrent neural network t...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-0608-8
更新日期：2020-04-01 00:00:00
abstract：:The painful sensations produced by a laceration, freeze, burn, muscle strain or internal injury are readily distinguishable because each is characterized by a particular sensory quality such as sharp, aching, burning or prickling. We propose that there are specific neural correlates of each pain quality, and here we u...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn955
更新日期：2002-11-01 00:00:00
abstract：:Cannabis is the most frequently used illicit psychoactive substance worldwide; around one in ten users become dependent. The risk for cannabis use disorder (CUD) has a strong genetic component, with twin heritability estimates ranging from 51 to 70%. Here we performed a genome-wide association study of CUD in 2,387 ca...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0416-1
更新日期：2019-07-01 00:00:00
abstract：:Dendritic spines are motile structures that contain high concentrations of filamentous actin. Using hippocampal neurons expressing fluorescent actin and the method of fluorescence recovery after photobleaching, we found that 85 +/- 2% of actin in the spine was dynamic, with a turnover time of 44.2 +/- 4.0 s. The rapid...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn811
更新日期：2002-03-01 00:00:00
abstract：:In Huntington's disease (HD), expansion of CAG codons in the huntingtin gene (HTT) leads to the aberrant formation of protein aggregates and the differential degeneration of striatal medium spiny neurons (MSNs). Modeling HD using patient-specific MSNs has been challenging, as neurons differentiated from induced plurip...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0075-7
更新日期：2018-03-01 00:00:00
abstract：:Several ion channels are thought to be directly modulated by nitric oxide (NO), but the molecular basis of this regulation is unclear. Here we show that the NMDA receptor (NMDAR)-associated ion channel was modulated not only by exogenous NO but also by endogenous NO. Site-directed mutagenesis identified a critical cys...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/71090
更新日期：2000-01-01 00:00:00
abstract：:Neuronal development, plasticity and survival require activity-dependent synapse-to-nucleus signaling. Most studies implicate an activity-dependent regulation of gene expression in this phenomenon. However, little is known about other nuclear functions that are regulated by synaptic activity. Here we show that a newly...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1867
更新日期：2007-04-01 00:00:00
abstract：:Neurons in thalamorecipient layers of sensory cortices integrate thalamocortical and intracortical inputs. Although we know that their functional properties can arise from the convergence of thalamic inputs, intracortical circuits could also be involved in thalamocortical transformations of sensory information. We sil...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3494
更新日期：2013-09-01 00:00:00
abstract：:Neuronal migration disorders such as lissencephaly and subcortical band heterotopia are associated with epilepsy and intellectual disability. DCX, PAFAH1B1 and TUBA1A are mutated in these disorders; however, corresponding mouse mutants do not show heterotopic neurons in the neocortex. In contrast, spontaneously arisen...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3729
更新日期：2014-07-01 00:00:00
abstract：:Trial-to-trial variability in the blood oxygen level-dependent (BOLD) response of functional magnetic resonance imaging has been shown to be relevant to human perception and behavior, but the sources of this variability remain unknown. We demonstrate that coherent spontaneous fluctuations in human brain activity accou...
journal_title：Nature neuroscience
pub_type： 临床试验,杂志文章
doi：10.1038/nn1616
更新日期：2006-01-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-020-00723-2
更新日期：2020-11-01 00:00:00
abstract：:Trafficking of AMPA receptors (AMPARs) is important for many forms of synaptic plasticity. However, the link between activity and resulting synaptic alterations is not fully understood. We identified a direct interaction between N-ethylmaleimide-sensitive fusion protein (NSF), an ATPase involved in membrane fusion eve...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2624
更新日期：2010-10-01 00:00:00
abstract：:What neural activity in motor cortex represents and how it controls ongoing movement remain unclear. Suggestions that cortex generates low-level muscle control are discredited by correlations with higher-level parameters of hand movement, but no coherent alternative exists. I argue that the view of low-level control i...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/73964
更新日期：2000-04-01 00:00:00
abstract：:Nature Neuroscience presents a special issue of recent advances on shared mechanisms underlying neurodegenerative disease. ...
journal_title：Nature neuroscience
pub_type： 社论
doi：10.1038/s41593-018-0250-x
更新日期：2018-10-01 00:00:00
abstract：:In mammals, olfaction is often used to distinguish individuals on the basis of their unique odor types (genetically programmed body odors). Parental-offspring recognition behavior is mediated, in part, by learning and processing of different odor types and is crucial for reproductive success. Maternal recognition beha...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2550
更新日期：2010-06-01 00:00:00
