Abstract：
:We show that a natural behavior, exploration of a novel environment, causes DNA double-strand breaks (DSBs) in neurons of young adult wild-type mice. DSBs occurred in multiple brain regions, were most abundant in the dentate gyrus, which is involved in learning and memory, and were repaired within 24 h. Increasing neuronal activity by sensory or optogenetic stimulation increased neuronal DSBs in relevant but not irrelevant networks. Mice transgenic for human amyloid precursor protein (hAPP), which simulate key aspects of Alzheimer's disease, had increased neuronal DSBs at baseline and more severe and prolonged DSBs after exploration. Interventions that suppress aberrant neuronal activity and improve learning and memory in hAPP mice normalized their levels of DSBs. Blocking extrasynaptic NMDA-type glutamate receptors prevented amyloid-β (Aβ)-induced DSBs in neuronal cultures. Thus, transient increases in neuronal DSBs occur as a result of physiological brain activity, and Aβ exacerbates DNA damage, most likely by eliciting synaptic dysfunction.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Suberbielle E,Sanchez PE,Kravitz AV,Wang X,Ho K,Eilertson K,Devidze N,Kreitzer AC,Mucke Ldoi
10.1038/nn.3356subject
Has Abstractpub_date
2013-05-01 00:00:00pages
613-21issue
5eissn
1097-6256issn
1546-1726pii
nn.3356journal_volume
16pub_type
杂志文章abstract：:Neurons in many species have large receptive fields that are selective for specific optic flow fields. Here, we studied the neural mechanisms underlying flow field selectivity in lobula plate tangential cells (LPTCs) of the blowfly. Among these cells, the H2 cell responds preferentially to visual stimuli approximating...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1769
更新日期：2006-10-01 00:00:00
abstract：:Human observers adapted to complex biological motions that distinguish males from females: viewing the gait of one gender biased judgments of subsequent gaits toward the opposite gender. This adaptation was not simply due to local features of the stimuli but instead relied upon the global motion of the figures. These ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1710
更新日期：2006-06-01 00:00:00
abstract：:We investigated the regulation of T-type channels by Rho-associated kinase (ROCK). Activation of ROCK via the endogenous ligand lysophosphatidic acid (LPA) reversibly inhibited the peak current amplitudes of rat Ca(v)3.1 and Ca(v)3.3 channels without affecting the voltage dependence of activation or inactivation, wher...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1921
更新日期：2007-07-01 00:00:00
abstract：:The brain transforms physical sensory stimuli into meaningful perceptions. In animals making choices about sensory stimuli, neuronal activity in successive cortical stages reflects a progression from sensation to decision. Feedforward and feedback pathways connecting cortical areas are critical for this transformation...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4356
更新日期：2016-09-01 00:00:00
abstract：:Hippocampal CA1 pyramidal neurons have frequently been regarded as a homogeneous cell population in biophysical, pharmacological and modeling studies. We found robust differences between pyramidal neurons residing in the deep and superficial CA1 sublayers in rats. Compared with their superficial peers, deep pyramidal ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2894
更新日期：2011-08-07 00:00:00
abstract：:UTX is a chromatin modifier required for development and neural lineage specification, but how it controls these biological processes is unclear. To determine the molecular mechanisms of UTX, we identified novel UTX protein interaction partners. Here we show that UTX and 53BP1 directly interact and co-occupy promoters...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0328-5
更新日期：2019-03-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2540
更新日期：2010-06-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/6368
更新日期：1999-03-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1377
更新日期：2005-02-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3905
更新日期：2015-02-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2172
更新日期：2008-09-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0353-z
更新日期：2019-04-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn884
更新日期：2002-08-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1121
更新日期：2003-10-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.3234
更新日期：2012-11-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3215
更新日期：2012-10-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1038/nn945
更新日期：2002-11-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/393
更新日期：1998-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/nn.4457
更新日期：2017-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/nn0901-894
更新日期：2001-09-01 00:00:00
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更新日期：2011-10-23 00:00:00
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更新日期：2010-05-01 00:00:00
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pub_type： 评论,新闻
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更新日期：2010-09-01 00:00:00
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更新日期：2005-05-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2004-02-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
