Adenovirus-mediated gene transfer of basic fibroblast growth factor promotes the survival of primary-cultured rat neuronal cells.

abstract：:Anti-leucine-rich glioma inactivated 1 (anti-LGI1) encephalitis is one of the most frequently encountered forms of autoimmune encephalitis. Many patients with anti-LGI1 encephalitis develop permanent hippocampal neuron loss and chronic neuropsychiatric symptoms, suggesting that LGI antibodies (Ab) might have a neuroto...

journal_title：Neuroreport

authors： Ayşit-Altuncu N,Ulusoy C,Öztürk G,Tüzün E

更新日期：2018-08-01 00:00:00

abstract：:Papaverine is a non-specific vasodilatory drug, which was found to unexpectedly cause opening of the blood-brain barrier (BBB). We studied the expression of two endothelial cell related markers, endothelial barrier antigen (EBA) as a marker of BBB intactness, and matrix metalloproteinase-9 (MMP-9), an extracellular ma...

journal_title：Neuroreport

authors： Bhattacharjee AK,Kondoh T,Ikeda M,Kohmura E

更新日期：2002-12-03 00:00:00

abstract：:The whole cell configuration of the patch clamp technique was used to study the biophysical and pharmacological properties of voltage activated Ca2+ channel currents on hippocampal neurones cultured in the presence or absence of foetal calf serum. In the presence of serum cells were intensively immunostained with neur...

journal_title：Neuroreport

authors： Bertollini L,Cattaneo A,Cherubini E

更新日期：1995-04-19 00:00:00

abstract：:Using NADPH-diaphorase (NADPH-d) staining as a marker for the enzyme nitric oxide synthase (NOS) we investigated the possible sites of nitric oxide (NO) synthesis in the olfactory pathways of an insect brain. Staining of frozen sections revealed NADPH-d activity in neurones and in glial cells. A cluster of intensely s...

journal_title：Neuroreport

authors： Bicker G,Hähnlein I

更新日期：1995-01-26 00:00:00

abstract：:Insulin-like growth factor (IGF)-I is essential for cerebellar granule neuron survival and a decline in IGF-I is implicated in various age-dependent processes. Here we show that IGF-I mRNA levels are decreased in the cerebellum of old rats compared with young rats and this was associated with increased cell death and ...

journal_title：Neuroreport

authors： Pañeda C,Arroba AI,Frago LM,Holm AM,Rømer J,Argente J,Chowen JA

更新日期：2003-08-26 00:00:00

abstract：OBJECTIVE:This study aimed to observe the effect of glutamine (Gln) on brain damage in septic rats and explore its possible mechanism. METHODS:Ninety-three Sprague-Dawley rats were randomly divided into five groups: sham operation group, sepsis group, Gln-treated group, quercetin/Gln-treated group, and alloxan/Gln-tre...

journal_title：Neuroreport

authors： Wang J,Lu X,Zheng K,Jing L

更新日期：2021-01-18 00:00:00

abstract：:Emerging evidence has suggested that alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) protects neurons from glutamate-induced neurotoxicity. In this study, we examined the effect of AMPA on the cell surface expression of the N-methyl-D-aspartate (NMDA) receptor, a central player in glutamate-induced neurot...

journal_title：Neuroreport

authors： Nishimoto T,Kihara T,Akaike A,Niidome T,Sugimoto H

更新日期：2009-01-28 00:00:00

abstract：:We studied the neural substrate of anticipation and learning of smooth pursuit eye movements in humans using fMRI. Both predictable and non-predictable eye movements, compared to baseline, activated a common network previously associated with oculomotor function. The temporal dynamics of activity in a subset of these ...

journal_title：Neuroreport

authors： Schmid A,Rees G,Frith C,Barnes G

更新日期：2001-05-25 00:00:00

abstract：:Temporal changes of serotonin (5-HT) content in the median (MRN) and dorsal (DRN) raphe nuclei were measured in rats kept under various lighting conditions. Serotonin content in the MRN and DRN under light-dark (LD) condition showed diurnal rhythmicity, with a peak during early light phase and a trough during the dark...

journal_title：Neuroreport

authors： Cagampang FR,Yamazaki S,Otori Y,Inouye SI

更新日期：1993-10-25 00:00:00

abstract：:Oleic acid, a cis-unsaturated free fatty acid, is proposed to be involved in the protein kinase C (PKC) activation pathway. Its biological actions, however, have not been well-characterized. We examined the effects of oleic acid on acetylcholine (ACh)-gated channel currents using Torpedo nicotinic ACh receptors expres...

journal_title：Neuroreport

authors： Nishizaki T,Ikeuchi Y,Matsuoka T,Sumikawa K

更新日期：1997-02-10 00:00:00

abstract：:The effect of neonatal axotomy on the maturation of motoneurone somadendritic morphology was studied in identified motoneurones innervating the ankle dorsiflexor muscles tibialis anterior (TA) and extensor digitorum longus (EDL) of the rat by intracellular injection of Lucifer Yellow and confocal microscopy. At birth,...

journal_title：Neuroreport

authors： Dekkers J,Navarrete R

更新日期：1998-05-11 00:00:00

abstract：:It is widely accepted that prostaglandin (PG) E2 is the principal pro-inflammatory prostanoid and plays an important role in inflammatory pain. However whether PGE2 is involved in neuropathic pain remains unknown. PGE2 is produced from arachidonic acid via PGH2 by at least three PGE synthases (PGES), cytosolic PGES (c...

journal_title：Neuroreport

authors： Mabuchi T,Kojima H,Abe T,Takagi K,Sakurai M,Ohmiya Y,Uematsu S,Akira S,Watanabe K,Ito S

更新日期：2004-06-28 00:00:00

abstract：:Positron emission tomography (PET) was used to investigate cerebral organization in seven subjects who had Mandarin Chinese as their native language (L1), and learned English (L2) later in life. When activation from word repetition was subtracted from verb generation in L1 and L2, CBF increases were observed for both ...

journal_title：Neuroreport

authors： Klein D,Milner B,Zatorre RJ,Zhao V,Nikelski J

更新日期：1999-09-09 00:00:00

abstract：:Elevations of cytosolic free Ca2+ concentration ([Ca2+]i) induced by addition of ATP have been compared in rat dorsal horn neurones in slices and after their isolation. ATP application induced in neurones in situ a rise of [Ca2+]i by 201 +/- 12 nM. In Ca2+-free external solution the rise was 156 +/- 14 nM (n = 45 of 7...

journal_title：Neuroreport

authors： Kruglikov I,Shutov L,Potapenko E,Voitenko N,Kostyuk P

更新日期：2001-11-16 00:00:00

abstract：:BALB/c mice were trained in a partial acquisition session of an appetitive bar-pressing task. They then received an immediate post-acquisition i.p. injection of either saline or apamin 0.2 mg kg-1. Each group was submitted to a retention test that was delayed either 25, 85 or 180 min after initial acquisition. In sali...

journal_title：Neuroreport

authors： Belcadi-Abbassi W,Destrade C

更新日期：1995-06-19 00:00:00

abstract：:Alpha-Synuclein is a major component of neuronal and glial cytoplasmic inclusions in multiple system atrophy (MSA), one of the alpha-synucleinopathies. Recent studies have shown that beta-synuclein, a homolog of alpha-synuclein, inhibits alpha-synuclein aggregation in vitro. We immunohistochemically examined the MSA b...

journal_title：Neuroreport

authors： Mori F,Nishie M,Yoshimoto M,Takahashi H,Wakabayashi K

更新日期：2003-10-06 00:00:00

abstract：:Retinal light exposure induces several immediate-early genes in the hypothalamic suprachiasmatic nucleus (SCN), which contains the major circadian pacemaker of mammals. Clock-controlled and light-induced genes expressed in the SCN such as c- and contain upstream regulatory elements similar to those of the major immedi...

journal_title：Neuroreport

authors： Sigworth LA,Liao L,Chandler TR,Geusz ME

更新日期：2003-03-03 00:00:00

abstract：:One approach to understanding the function of presenilin 1 (PS1), is to discover those proteins with which it interacts. Evidence for a function in developmental patterning came from C. elegans, in which a PS homologue was identified by screening for suppressors of a mutation in Notch/lin-12, a gene which specifies ce...

journal_title：Neuroreport

authors： Zhou J,Liyanage U,Medina M,Ho C,Simmons AD,Lovett M,Kosik KS

更新日期：1997-04-14 00:00:00

abstract：:Event-related potentials (ERPs) were measured from 24 chronic closed head injury (CHI) patients and 18 age- and education-matched controls. The oddball paradigm was applied while subjects were watching a silent movie. The standard (p=0.8) sound of 75 ms duration had a basic frequency of 500 Hz with harmonic partials o...

journal_title：Neuroreport

authors： Kaipio ML,Novitski N,Tervaniemi M,Alho K,Ohman J,Salonen O,Näätänen R

更新日期：2001-05-25 00:00:00

abstract：:The benzodiazepine, lorazepam enhances the efficiency of local, inhibitory GABA(A) synapses in the cortex, which stabilize postsynaptic, excitatory activity by synchronizing their own discharges at around 40 Hz. Treatment with lorazepam has also been shown to adversely influence detection performance in perceptual tas...

journal_title：Neuroreport

authors： Elliott MA,Becker C,Boucart M,Müller HJ

更新日期：2000-10-20 00:00:00

abstract：:As manifestations of prion diseases include disturbances of hypothalamic and pituitary functions, we tested the hypothesis that the cellular prion protein (PrPC) has a role as modulator of the hypothalamic-pituitary-adrenal axis. The level of corticosterone and adrenocorticotropic hormone were compared in PrPC null (P...

journal_title：Neuroreport

authors： Sanchez-Alavez M,Criado JR,Klein I,Moroncini G,Conti B

更新日期：2008-10-08 00:00:00

abstract：:Human brain homogenate proteins were analyzed for binding and processing activity in relation to brain beta-amyloid precursor protein (APP). The homogenate was purified by arginine-Sepharose 4B affinity chromatography, which traps proteins with affinity to certain groups of arginine residue, such as serine proteases a...

journal_title：Neuroreport

authors： Matsumoto A,Minami M,Matsumoto R

更新日期：1997-10-20 00:00:00

abstract：:We used whole-cell recording to identify, for the first time, GABAergic tonic current in subpopulations of substantia gelatinosa neurons in mouse spinal cord slices. Application of the gamma-aminobutyric acid type A receptor antagonist bicuculline revealed tonic currents in 49 of 73 substantia gelatinosa neurons. Thes...

journal_title：Neuroreport

authors： Takahashi A,Mashimo T,Uchida I

更新日期：2006-08-21 00:00:00

abstract：:The aim of this study is to investigate the neural mechanism of extending a brand in a specific product category to other product categories. Facing two sequential stimuli in pairs consisting of beverage brand names (stimulus 1) and product names (stimulus 2) in other categories, 16 participants were asked to indicate...

journal_title：Neuroreport

authors： Ma Q,Wang X,Dai S,Shu L

更新日期：2007-07-02 00:00:00

abstract：:The changes of nitric oxide synthase (NOS) activity and nitrite level in rat brain regions after spatial learning were investigated. NOS activity was assayed by conversion of [3H]L-arginine to [3H]L-citrulline, and a sensitive fluorometric assay for quantification of nitrite was used. Compared with sham-trained rats, ...

journal_title：Neuroreport

authors： Chen J,Zhang S,Zuo P,Tang L

更新日期：1997-05-06 00:00:00

abstract：:Alopecia areata (AA) is a dermatosis involving the sudden occurrence of bald patches on the scalp. Although the aetiology is unknown, experimental data indicate that cutaneous microcirculation plays an important role. The skin is richly innervated by neuropeptidergic sensory nerves that help regulate microvascular cir...

journal_title：Neuroreport

authors： Rossi R,Del Bianco E,Isolani D,Baccari MC,Cappugi P

更新日期：1997-03-24 00:00:00

abstract：:Changes in the regulation, formation, and gating of connexin-based gap junction channels occur in various disorders. It has been shown that H and Ca are involved in the regulation of gap junctional communication. Ischemia-induced intracellular acidification and Ca overload lead to closure of gap junctions and inhibit ...

journal_title：Neuroreport

authors： Kucheryavykh LY,Benedikt J,Cubano LA,Skatchkov SN,Bukauskas FF,Kucheryavykh YV

更新日期：2017-03-01 00:00:00

abstract：:Synaptic vesicles contain a protein (agglutinin) which binds cell plasma membranes. The protein activity is titrated measuring the agglutination of rabbit trypsinized-fixed red blood cells induced by serial dilutions of purified vesicles. The protein is highly concentrated in vesicles: the specific activity is 150-fol...

journal_title：Neuroreport

authors： Popoli M,Paterno R

更新日期：1991-02-01 00:00:00

abstract：:Numerous reports have shown that cyclin-dependent kinase 5 (Cdk5), a proline-directed serine/threonine kinase, critically contributes to the induction and maintenance of chronic pain induced by peripheral inflammation and nerve injury. Recent evidence has also suggested the critical role of an epigenetic mechanism in ...

journal_title：Neuroreport

authors： Li K,Zhao GQ,Li LY,Wu GZ,Cui SS

更新日期：2014-10-01 00:00:00

abstract：:TA20 cDNA was previously cloned as a neurite outgrowth factor from a hybridoma of mouse and rat cells, NG108-15. To clarify the detailed function and tissue distribution of this gene, homologous sequences of rat and mouse were identified. The cloned sequences had no homology with known genes, and was designated as spr...

journal_title：Neuroreport

authors： Tohda C,Jacobowitz DM

更新日期：1999-07-13 00:00:00