Hypothalamic-pituitary-adrenal axis disregulation in PrPC-null mice.

Abstract:

:As manifestations of prion diseases include disturbances of hypothalamic and pituitary functions, we tested the hypothesis that the cellular prion protein (PrPC) has a role as modulator of the hypothalamic-pituitary-adrenal axis. The level of corticosterone and adrenocorticotropic hormone were compared in PrPC null (PrP 0/0) and wild-type (PrP+/+) mice. PrP 0/0 showed hypercorticism during the dark part of day. After acute stress, corticosterone and adrenocorticotropic hormone increased similarly in PrP+/+ and PrP 0/0 mice. Adrenocorticotropic hormone, however, remained elevated in PrP+/+ 0/0 mice at corticosterone levels that are inhibitory in PrP mice. Pretreatment with corticosterone or dexamethasone inhibited stress-induced elevation of adrenocorticotropic hormone in PrP+/+ but not in PrP 0/0 mice. Thus, PrPC may play a role in the negative feedback regulation of axis.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Sanchez-Alavez M,Criado JR,Klein I,Moroncini G,Conti B

doi

10.1097/WNR.0b013e32830f1e90

subject

Has Abstract

pub_date

2008-10-08 00:00:00

pages

1473-7

issue

15

eissn

0959-4965

issn

1473-558X

pii

00001756-200810080-00006

journal_volume

19

pub_type

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