Memory-related changes of nitric oxide synthase activity and nitrite level in rat brain.

Abstract:

:The changes of nitric oxide synthase (NOS) activity and nitrite level in rat brain regions after spatial learning were investigated. NOS activity was assayed by conversion of [3H]L-arginine to [3H]L-citrulline, and a sensitive fluorometric assay for quantification of nitrite was used. Compared with sham-trained rats, NOS activity and nitrite level in hippocampus and cortex, and also the nitrite level in cerebellum, was elevated significantly one day after rats had learnt a water-rewarded spatial alteration task. These results suggest a spatial memory-related changes of endogenous NO in rat brain, and support the idea that NO participates in learning and memory processes.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Chen J,Zhang S,Zuo P,Tang L

doi

10.1097/00001756-199705060-00040

subject

Has Abstract

pub_date

1997-05-06 00:00:00

pages

1771-4

issue

7

eissn

0959-4965

issn

1473-558X

journal_volume

8

pub_type

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