Abstract:
:Insulin-like growth factor (IGF)-I is essential for cerebellar granule neuron survival and a decline in IGF-I is implicated in various age-dependent processes. Here we show that IGF-I mRNA levels are decreased in the cerebellum of old rats compared with young rats and this was associated with increased cell death and activation of caspases 3 and 9. Growth hormone-releasing peptide (GHRP)-6, a synthetic ligand for the ghrelin receptor, increased IGF-I mRNA levels, decreased cell death and inhibited caspase 3 and 9 activation in the cerebellum of aged rats. These results suggest that increasing IGF-I expression in the cerebellum can decrease cell death in aged rats via inhibition of caspase 3 and 9 activation.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Pañeda C,Arroba AI,Frago LM,Holm AM,Rømer J,Argente J,Chowen JAdoi
10.1097/00001756-200308260-00018subject
Has Abstractpub_date
2003-08-26 00:00:00pages
1633-5issue
12eissn
0959-4965issn
1473-558Xjournal_volume
14pub_type
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