Abstract:
:The effect of neonatal axotomy on the maturation of motoneurone somadendritic morphology was studied in identified motoneurones innervating the ankle dorsiflexor muscles tibialis anterior (TA) and extensor digitorum longus (EDL) of the rat by intracellular injection of Lucifer Yellow and confocal microscopy. At birth, the entire somatodendritic surface is covered with fine filopodial growth-associated processes. These are eliminated from the soma and proximal dendrites during the first postnatal week as part of a somatofugal process of dendritic maturation. Following neonatal axotomy, the postnatal elimination of growth associated processes was halted and new, axonal-like processes were seen to sprout from the soma and proximal dendrites in some of the axotomized motoneurones. These results indicate that synaptic interaction with the target muscle during the early postnatal period is essential for the maturation of the somatodendritic receptive surface of the motoneurone.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Dekkers J,Navarrete Rdoi
10.1097/00001756-199805110-00051subject
Has Abstractpub_date
1998-05-11 00:00:00pages
1523-7issue
7eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::We describe a method for applying the carbocyanine dye DiI to the rat heart that takes advantage of the dye's lipophilic properties and its ability to diffuse easily into tissues, and results in specific retrograde labelling of cardiac vagal preganglionic neurones in the medulla oblongata. Most of the labelled neurone...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199904260-00004
更新日期:1999-04-26 00:00:00
abstract::Motor imagery paradigms can be used to investigate motor preparation. We used positron emission tomography to compare regional cerebral blood flow (rCBF) in patients with Parkinson's disease and normal controls under three conditions: rest, motor imagery and motor execution. In controls, imagery activated bilateral do...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200103260-00040
更新日期:2001-03-26 00:00:00
abstract::Net-like structures surrounding several types of neurones contain glycoconjugates which are detectable by lectins specific for N-acetylgalactosamine. Wisteria floribunda agglutinin (WFA) was introduced as a further marker for the visualization of such perineuronal nets, which were also revealed in regions of the rat b...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199210000-00012
更新日期:1992-10-01 00:00:00
abstract:OBJECTIVE:We sought to determine whether cortical excitability, measured via transcranial magnetic stimulation (TMS), is associated with cognition in healthy individuals and whether gender and education have an impact on this relationship. METHODS:Fifty-four healthy individuals (31 males, mean age = 41.94, SD = 21.98;...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001392
更新日期:2020-03-04 00:00:00
abstract::Using reverse transcription-polymerase chain reaction and in situ hybridization, we investigated the expression and cellular localization of ciliary neurotrophic factor receptor alpha (CNTFRalpha) in the rat retina following optic nerve transection (ONT). Following ONT, a signal for CNTFRalpha mRNA appeared in a layer...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200011270-00057
更新日期:2000-11-27 00:00:00
abstract::To investigate the origin of high-frequency somatosensory evoked potential (SEP) components, we recorded median nerve SEPs from the scalp and the depth in six monkeys. Laminar field potentials were analyzed in area 3b (N10; corresponding to human N20) and area 1 (P12; corresponding to human P25). After digital filteri...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200008210-00042
更新日期:2000-08-21 00:00:00
abstract::We investigated the effects of 2,2,2-trichloroethanol (TCE), the active metabolite of chloral hydrate, on large-conductance calcium-activated K+ channels (BKCa channels) of dorsal root ganglion (DRG) neurones. In outside-out patches, 2 and 5 mM TCE increased the open probability of BKCa channels to 1.7-fold and 2.8-fo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200205070-00023
更新日期:2002-05-07 00:00:00
abstract::There are remarkable behavioral, neural, and genetic similarities between song learning in songbirds and speech acquisition in human infants. Previously, we have argued that this parallel cannot be extended to the level of sentence syntax. Although birdsong can indeed have a complex structure, it lacks the combinatori...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32834f1765
更新日期:2012-02-15 00:00:00
abstract::In this study, the brainstem-spinal cord preparation isolated from newborn rats, an established model for the study of the hypoxic respiratory depression (HRD), has been used. The comparison of Fos expression in ponto-medullary areas in these preparations placed either in normoxic or hypoxic conditions suggests that o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200112210-00012
更新日期:2001-12-21 00:00:00
abstract::An important issue regarding the neural basis of major depression is whether the functional brain changes associated with the affect disturbance seen in this syndrome are similar to those that accompany transient sadness in normal subjects. To address this question, we carried out an fMRI study using an emotional acti...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199810050-00022
更新日期:1998-10-05 00:00:00
abstract::Pharmacologically distinct NMDA-glutamate receptor subtypes have been reported in brain. We have studied the developmental expression of the mRNA encoding the NMDA receptor NR2C subunit in the rat brain by in situ hybridization. In contrast with the adult where no hybridization signal was detected in the hippocampus, ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199304000-00018
更新日期:1993-04-01 00:00:00
abstract::Bicuculline- and baclofen-insensitive GABA receptors (GABAC receptors) on bipolar cells acutely dissociated from carp retina were investigated with using the whole-cell patch-clamp recording technique. The currents of these cells mediated by GABAC receptors showed striking desensitization, even at low concentrations o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199704140-00003
更新日期:1997-04-14 00:00:00
abstract::Reading is a learned skill that is likely influenced by both brain maturation and experience. Functional imaging studies have identified brain regions important for skilled reading, but the structural brain changes that co-occur with reading acquisition remain largely unknown. We investigated maturational volume chang...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000121
更新日期:2014-03-26 00:00:00
abstract::Recently it has been reported that a missense G(88)C mutation within exon 3 and a missense G(209)A mutation within exon 4 of the alpha-synuclein gene were linked to familial Parkinson's Disease (PD). We decided to investigate if these and any other mutations in exons 3 and 4 of the alpha-synuclein gene could be detect...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199812010-00029
更新日期:1998-12-01 00:00:00
abstract::Studies in zebra finches failed to demonstrate the involvement of the NIf, a higher-order song nucleus afferent to the HVc, in the production of learned song. The song of the Bengalese finch, a related species, has a higher level of temporal organization; multiple song phrases are organized into a song. We hypothesize...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200007140-00007
更新日期:2000-07-14 00:00:00
abstract::Skin sensory nerve nocifensor functions were investigated non-invasively in rats by measuring neurogenic inflammation and blister healing-rate after unilateral hindlimb denervation. Axon reflexes were evoked by transdermal iontophoresis of acetylcholine (ACh) or noxious electrical stimulation (TNS). Sodium nitroprussi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199305000-00001
更新日期:1993-05-01 00:00:00
abstract::Glutamate excitotoxicity has been suggested to play a role in amyotrophic lateral sclerosis (ALS), yet it remains unclear why some groups of motoneurons (MNs) are more vulnerable to degeneration than others. Our aim was to compare, in normal adult rats, the expression of Group I metabotropic glutamate receptors (mGluR...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200107030-00027
更新日期:2001-07-03 00:00:00
abstract::Music is an essential communication tool that can convey emotional information. Segmentation of a sound stream of music at event boundaries is necessary for identification and extraction of musical context and features. To investigate recognition of music termination structure, or cadence, we composed music sequences ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000160
更新日期:2014-07-09 00:00:00
abstract::We examined differences in brain activity in response to two types of mechanical stimulation, which have been reported previously as being perceptually indistinguishable but having different impacts on autonomic reflexes. As an indicator of brain activity, glucose metabolism was evaluated by PET with 2-[F]fluoro-2-deo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32836164d4
更新日期:2013-05-29 00:00:00
abstract::Whole-cell recordings in voltage-clamp mode were performed on acutely isolated neurones from rat neocortex and neostriatum to examine the effects of the anticonvulsant phenytoin on a non-inactivating (persistent) Na+ current (INaP). INaP was chosen because it enhances neuronal excitability near firing threshold, which...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199509000-00017
更新日期:1995-09-11 00:00:00
abstract::Astrocytes induce blood-brain barrier (BBB) properties in brain endothelial cells (EC)*O(2)*, generated in blood and EC, opens the BBB. Hence, high activity of superoxide dismutase (SOD) is a prerequisite for normal BBB function. Therefore, the influence of rat astrocytes on the expression of manganese (Mn)SOD in rat ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200108080-00045
更新日期:2001-08-08 00:00:00
abstract::The ATP-gated cation channel P2X3 is expressed selectively by rat sensory neurones, and may play a role in nociception by binding ATP released from damaged or inflamed tissues. However, the distribution of this channel in human sensory neurons is not known. Using a specific antibody, we have demonstrated intense P2X3 ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200004070-00019
更新日期:2000-04-07 00:00:00
abstract::The hypothesis that reactive free radical species (ROS) may contribute to the pathogenesis of Duchenne muscular dystrophy (DMD) has been suggested previously, but experimental data obtained in support of the above have to date proved inconclusive. The recent discovery that nitric oxide synthase (required for muscle re...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199612200-00070
更新日期:1996-12-20 00:00:00
abstract::The effect of centrally administered bombesin on core temperature was investigated in rats which had been chronically fitted with a cannula in the third cerebral ventricle and with an intraperitoneal temperature-monitoring radiotransmitter. Intracerebroventricularly administered bombesin (0.01, 0.1 or 1 microgram) res...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199403000-00026
更新日期:1994-03-21 00:00:00
abstract::Ts65DN mice were developed as a model of Down syndrome (DS); they are trisomic for the distal segment of chromosome 16 (MMU16), which contains genes syntenic with some of the genes located on the critical region of human chromosome 21 (HSA21). Since behavioral and neurochemical disturbances have been observed in this ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199711100-00012
更新日期:1997-11-10 00:00:00
abstract::In rapid serial visual presentation of pictures, an early event-related brain potential component shows enlarged negativity over occipital regions for emotional pictures compared with neutral pictures. The present study examined whether the processing of emotional target pictures varies as a function of stimulus repet...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000203355.88061.c6
更新日期:2006-03-20 00:00:00
abstract::The restriction of herpes virus latency to mammalian sensory ganglia has led to a search for tissue-specific regulatory molecules in these neurons which alter viral gene expression. Based primarily on work in sensory-related cell lines, several prior reports have suggested that the POU-domain transcription factor Oct-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199611250-00003
更新日期:1996-11-25 00:00:00
abstract::Peripheral nervous system injury may be corrected by surgical repair, but in many cases this is not possible and will result in loss of motor and sensory function. Schwann cells provide many neurotrophic signals essential for axon regeneration and immediately after injury inflammatory cytokines are released necessary ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200403010-00022
更新日期:2004-03-01 00:00:00
abstract::Nogo-66 receptor was first identified in neurons. Recently, it was demonstrated in glial cells as well. Our previous study on the expression of Nogo-66 receptor in the cerebellum of the rat surprisingly found its location at the glial gap junctions. Here, we present our study on Nogo-66 receptor in the rat posterior p...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200604240-00010
更新日期:2006-04-24 00:00:00
abstract::Retinal light exposure induces several immediate-early genes in the hypothalamic suprachiasmatic nucleus (SCN), which contains the major circadian pacemaker of mammals. Clock-controlled and light-induced genes expressed in the SCN such as c- and contain upstream regulatory elements similar to those of the major immedi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200303030-00029
更新日期:2003-03-03 00:00:00