The beta-amyloid epitope masking activity in human brain is identified as albumin.

Abstract:

:Human brain homogenate proteins were analyzed for binding and processing activity in relation to brain beta-amyloid precursor protein (APP). The homogenate was purified by arginine-Sepharose 4B affinity chromatography, which traps proteins with affinity to certain groups of arginine residue, such as serine proteases and zymogens. A 69 kDa protein that masks epitope(s) of brain APP was found in a weakly bound fraction. The nature of the 69 kDa brain protein was identified as albumin by N-terminal amino acid sequencing and Western blot analysis using anti-human albumin antibody. Western blot analysis with domain-specific anti-APP antibodies revealed that the masking activity is complete for beta-amyloid epitope(s), but incomplete for cytoplasmic and extracellular domain epitopes, suggesting that the interaction site of the albumin is beta-amyloid itself. Therefore, it seems that brain albumin is not merely a carrier protein for beta-amyloid in cerebrospinal fluid, but also a modulator which interferes with processing of beta-amyloid precursor protein and its peptides.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Matsumoto A,Minami M,Matsumoto R

doi

10.1097/00001756-199710200-00021

subject

Has Abstract

pub_date

1997-10-20 00:00:00

pages

3297-301

issue

15

eissn

0959-4965

issn

1473-558X

journal_volume

8

pub_type

杂志文章
  • Neurophysiological evidence for the country-of-origin effect: an event-related potential study.

    abstract::Consumers often rely on observable cues that hint at the hidden quality of a product. The aim of this study was to investigate brain activities associated with the country-of-origin (COO) effect and consumer evaluation of a product design. Electroencephalogram recordings were used to observe event-related brain potent...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000102

    authors: Min BK,Cho K,Sung J,Cho E

    更新日期:2014-03-05 00:00:00

  • Desensitizing GABAC receptors on carp retinal bipolar cells.

    abstract::Bicuculline- and baclofen-insensitive GABA receptors (GABAC receptors) on bipolar cells acutely dissociated from carp retina were investigated with using the whole-cell patch-clamp recording technique. The currents of these cells mediated by GABAC receptors showed striking desensitization, even at low concentrations o...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199704140-00003

    authors: Han MH,Li Y,Yang XL

    更新日期:1997-04-14 00:00:00

  • On the origin of Alzheimer's disease: a hypothesis.

    abstract::There is no unifying hypothesis to account for the anatomical distribution of neuropathology, the involvement of beta-amyloid precursor protein (beta APP) and the role of increasing age in triggering the Alzheimer disease process. We report here that layer II pre-alpha neurones in transentorhinal and entorhinal cortex...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199301000-00001

    authors: Roberts GW,Nash M,Ince PG,Royston MC,Gentleman SM

    更新日期:1993-01-01 00:00:00

  • Modelling transfer characteristics of vestibular neurons in the fastigial nucleus of the behaving monkey on the basis of canal-otolith interaction.

    abstract::The interaction of vestibular inputs with different dynamic and spatial behavior, i.e., canal-otolith interaction, leads to spatio-temporal convergence. Vestibular neurons in the fastigial nucleus often exhibit spatio-temporal convergence. The present report demonstrates that the discharge rates of most vestibular neu...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200205070-00013

    authors: Wilden A,Glasauer S,Kleine JF,Büttner U

    更新日期:2002-05-07 00:00:00

  • Selective interference reveals dissociation between memory for location and colour.

    abstract::The aim was to study whether there is indication of a dissociation in processing of visuospatial and colour information in working memory in humans. Experimental subjects performed visuospatial and colour n-back tasks with and without visuospatial and colour distractive stimuli presented in the middle of the delay per...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199908020-00002

    authors: Vuontela V,Rämä P,Raninen A,Aronen HJ,Carlson S

    更新日期:1999-08-02 00:00:00

  • White matter integrity and math performance in pediatric multiple sclerosis: a diffusion tensor imaging study.

    abstract::Multiple sclerosis is associated with reduced white matter integrity and deficits in key cognitive processes important for arithmetic. This study examined the relationship between white matter microstructure and academic ability in 31 youths with multiple sclerosis (aged 11-19 years) and 34 demographically matched con...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32834dc301

    authors: Till C,Deotto A,Tipu V,Sled JG,Bethune A,Narayanan S,Arnold DL,Banwell BL

    更新日期:2011-12-21 00:00:00

  • Quadrupedal locomotor movements in monkeys (M. Fuscata) on a treadmill: kinematic analyses.

    abstract::Three adult Japanese monkeys (M. fuscata: body weights 4.5-8.5 kg) were trained to walk quadrupedally on a surface of a moving treadmill (walking length and width: 150 cm and 60 cm, treadmill speed: 0.4-1.7 m s-1. At any different constant treadmill velocity, the monkeys exhibited a diagonal pattern of locomotor movem...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199610020-00004

    authors: Mori S,Miyashita E,Nakajima K,Asanome M

    更新日期:1996-10-02 00:00:00

  • Antinociceptive effect of morphine microinjections into the spinal trigeminal subnucleus oralis.

    abstract::We analysed the effects of morphine microinjections (0.2 microliter) into the subnucleus oralis (SNO), i.e. the rostral division of the spinal trigeminal nucleus, on the formalin test adapted for orofacial pain. Duration of rubbing following an injection (50 microliters) of formalin solution (1.5%) in the right upper ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199501000-00034

    authors: Luccarini P,Cadet R,Saade M,Woda A

    更新日期:1995-01-26 00:00:00

  • Kainic acid-induced seizures activate GSK-3β in the hippocampus of D2R-/- mice.

    abstract::Dopamine D2 receptor (D2R) signalling is implicated in limbic seizure propagation and seizure-induced neurodegeneration. D2R-/- mice display increased susceptibility to kainic acid (KA) seizures and seizure-induced apoptosis of hippocampal neurons. Here we further investigated the molecular pathways of KA-induced apop...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32833d5891

    authors: Tripathi PP,Santorufo G,Brilli E,Borrelli E,Bozzi Y

    更新日期:2010-08-23 00:00:00

  • Orthovanadate induces cell death in rat dentate gyrus primary culture.

    abstract::The aim of this study was to define the effects of a potent inhibitor of tyrosine phosphatases, sodium orthovanadate (0.1-100 microM for up to 48 h), on dentate gyrus cells (DGC) in culture. Treatment with 100 microM orthovanadate evoked a delayed form of cell death. To examine the possible involvement of apoptosis in...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199707280-00011

    authors: Figiel I,Kaczmarek L

    更新日期:1997-07-28 00:00:00

  • Grape polyphenols protect neurodegenerative changes induced by chronic ethanol administration.

    abstract::Increased oxidative stress in the brain due to chronic ethanol consumption is known to result in a number of neurodegenerative changes. This study was designed to test whether dietary supplementation of grape polyphenols (GP) can offer protection to the neurodegenerative changes resulting from chronic ethanol consumpt...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199901180-00018

    authors: Sun GY,Xia J,Draczynska-Lusiak B,Simonyi A,Sun AY

    更新日期:1999-01-18 00:00:00

  • Abnormal anterior cingulum in patients with schizophrenia: a diffusion tensor imaging study.

    abstract::Diffusion tensor imaging (DTI) can non-invasively examine the molecular diffusion of water in vivo and directly reflects the anatomical integrity of neural fibers in white matter. Fractional anisotropy (FA) can be calculated from DTI data, and utilized to evaluate white matter integrity. DTI was performed on 30 patien...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200310060-00015

    authors: Sun Z,Wang F,Cui L,Breeze J,Du X,Wang X,Cong Z,Zhang H,Li B,Hong N,Zhang D

    更新日期:2003-10-06 00:00:00

  • Reproductive senescence predicts cognitive decline in aged female monkeys.

    abstract::The present investigation provide evidences from a non-human primate model that naturally occurring menopause predicts a prominent signature of age-related cognitive decline. Young and aged rhesus monkeys were tested on a delayed response (DR) task known to the sensitive to aging, and reproductive status was evaluated...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199705260-00048

    authors: Roberts JA,Gilardi KV,Lasley B,Rapp PR

    更新日期:1997-05-27 00:00:00

  • The functional neuroanatomy of major depression: an fMRI study using an emotional activation paradigm.

    abstract::An important issue regarding the neural basis of major depression is whether the functional brain changes associated with the affect disturbance seen in this syndrome are similar to those that accompany transient sadness in normal subjects. To address this question, we carried out an fMRI study using an emotional acti...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199810050-00022

    authors: Beauregard M,Leroux JM,Bergman S,Arzoumanian Y,Beaudoin G,Bourgouin P,Stip E

    更新日期:1998-10-05 00:00:00

  • Thiamine deficiency alters APP but not presenilin-1 immunoreactivity in vulnerable brain regions.

    abstract::Presenilin-1 (PS-1) and amyloid precursor protein (APP) have been linked to the pathogenesis of Alzheimer's disease. While APP accumulation is well documented in several models of brain injury, the role of PS-1 levels in neurodegeneration, if any, remains to be elucidated. The current studies examined PS-1 and APP exp...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199707280-00041

    authors: Calingasan NY,Gandy SE,Gibson GE

    更新日期:1997-07-28 00:00:00

  • Late developmental deficits in force control in children with hemiplegia.

    abstract::Differences related to development were investigated using a finger isometric force task in children with cerebral palsy and control children. The increase in force and force control observed in controls did not take place in patients. In the younger subset of patients (< 10 years) the force produced by the non-affect...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200408260-00020

    authors: Smits-Engelsman BC,Rameckers EA,Duysens J

    更新日期:2004-08-26 00:00:00

  • Basal forebrain neurons adjacent to the globus pallidus co-express GABAergic and cholinergic marker mRNAs.

    abstract::Semi-quantitative single cell RT-PCR techniques were used to determine the expression of mRNAs related to GABAergic and cholinergic neurotransmission in neurons of the rat globus pallidus and adjacent basal forebrain region. Neurons of the globus pallidus expressed relatively high levels of GAD67 and GABA vesicular tr...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199806220-00004

    authors: Tkatch T,Baranauskas G,Surmeier DJ

    更新日期:1998-06-22 00:00:00

  • Serum immunoglobulins in brain tumours and lumbar disc diseases.

    abstract::Changes of serum immunoglobulin (Ig) concentrations may occur in both brain tumours and lumbar disc diseases (LDD). The purpose of this study was to investigate the changes of pre- and post-operative serum Ig levels in brain tumours and LDDs. Serum IgG, IgA and IgM levels were measured in 127 patients with brain tumou...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-200002070-00011

    authors: Yüceer N,Arasil E,Temiz C

    更新日期:2000-02-07 00:00:00

  • Role of nitric oxide in 2-deoxy-D-glucose-induced hypothermia in rats.

    abstract::The present study was designed to test the hypothesis that nitric oxide (NO) plays a role in 2-deoxy-D-glucose (2-DG)-induced hypothermia. The body temperature of awake, unrestrained rats was measured before and after the administration of 2-DG, or N(G)-nitro-L-arginine methyl ester (L-NAME; a non-selective NOS inhibi...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199909290-00041

    authors: Carnio EC,Almeida MC,Fabris G,Branco LG

    更新日期:1999-09-29 00:00:00

  • Development of voltage-dependent inward currents in dissociated newt retinal pigment epithelial cells in culture.

    abstract::The whole-cell patch-clamp technique was employed to investigate the development of voltage-gated currents in cultured newt retinal pigment epithelial (RPE) cells. Freshly dissociated RPE cells were inexcitable and mainly exhibited a voltage-gated outward K+ current. Within a few days in culture RPE cells began to fla...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199404000-00020

    authors: Sakai H,Saito T

    更新日期:1994-04-14 00:00:00

  • Event-related potentials in an emotional go/no-go task and remission of geriatric depression.

    abstract::Anterior cingulate integrity may be required for antidepressant response. To assess anterior cingulate processes related to treatment response, we studied error-related negativity and error positivity produced during an emotional go/no-go challenge, a task activating the rostral anterior cingulate. Twelve elderly pati...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e328013ceda

    authors: Alexopoulos GS,Murphy CF,Gunning-Dixon FM,Kalayam B,Katz R,Kanellopoulos D,Etwaroo GR,Klimstra S,Foxe JJ

    更新日期:2007-02-12 00:00:00

  • Histamine slows the onset of desensitization of rat cortical NMDA receptors.

    abstract::The effects of histamine on N-methyl-d-aspartate (NMDA) receptor-mediated ion current in cultured rat cortical neurones have been investigated by superfusion of voltage-clamped (-80 mV) cells with 100 mM NMDA and with various concentrations of histamine. In a subpopulation of the neurones tested (30/53), histamine (10...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199609020-00030

    authors: Zwart R,Blank T,Spiess J

    更新日期:1996-09-02 00:00:00

  • Endurance exercise-induced expression of autophagy-related protein coincides with anabolic expression and neurogenesis in the hippocampus of the mouse brain.

    abstract::Autophagy and neurogenesis play a pivotal role in maintaining cellular homeostasis of neurons in the brain. Endurance exercise (EXE) serves as a potent regulator of both autophagy and neurogenesis in the hippocampus of the brain; however, the underlying molecular mechanisms of the dual expression remains unclear. Thus...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001431

    authors: Jang Y

    更新日期:2020-04-08 00:00:00

  • Modeling the control of reticular thalamic oscillations by neuromodulators.

    abstract::Compartmental models of thalamic reticular (RE) neurons were investigated based on current-clamp and voltage-clamp data. Spontaneous oscillations in the model arise from the interaction between inhibitory synaptic currents and the rebound burst of RE cells. These oscillations critically depend on the level of the rest...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199411000-00003

    authors: Destexhe A,Contreras D,Sejnowski TJ,Steriade M

    更新日期:1994-11-21 00:00:00

  • Acute ethanol decreases NPY mRNA but not POMC mRNA in the arcuate nucleus.

    abstract::The acute effects of ethanol and acetaldehyde on neuropeptide mRNA expression in the arcuate nucleus (ARC) was assessed. Acetaldehyde was increased in blood following ethanol with cyanamide (a potent inhibitor of aldehyde dehydrogenase) administration. Acetaldehyde is a toxin which can cause a variety of adverse effec...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200011090-00023

    authors: Kinoshita H,Jessop DS,Finn DP,Coventry TL,Roberts DJ,Ameno K,Ijiri I,Harbuz MS

    更新日期:2000-11-09 00:00:00

  • Neurometabolite changes in patients with complex regional pain syndrome using magnetic resonance spectroscopy: a pilot study.

    abstract::The aim of this study was to investigate distinct neurometabolites in the right and left thalamus and insula of patients with complex regional pain syndrome (CRPS) compared with healthy controls using proton magnetic resonance spectroscopy. Levels of N-acetylaspartate (NAA), N-acetylaspartylglutamate (NAAG), myo-inosi...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001168

    authors: Jung YH,Kim H,Jeon SY,Kwon JM,Kim YC,Lee WJ,Lee D,Lee JY,Moon JY,Kang DH

    更新日期:2019-01-16 00:00:00

  • TGFβ1 downregulates neurite outgrowth, expression of Ca2+ transporters, and mitochondrial dynamics of in vitro cerebellar granule cells.

    abstract::Acute injury to central nervous system (CNS) triggers neurodegenerative processes that can result in serious damage or complete loss of function. After injury, production of transforming growth factor β1 (TGFβ1) increases and initiates creation of a fibrotic scar that prevents normal growth, plasticity, and recovery o...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000106

    authors: Jaskova K,Pavlovicova M,Cagalinec M,Lacinova L,Jurkovicova D

    更新日期:2014-03-26 00:00:00

  • Potentiation and depression following stimulus interruption in young rat hippocampi.

    abstract::We examined the effect of stimulus interruption on dual component field EPSPs in the hippocampal CA1 region. Resuming test stimulation at 0.1 Hz after 10-60 min silent periods led to an increase of the response followed by a decline, involving AMPA and NMDA components to a similar extent. Similar changes were seen whe...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199904060-00005

    authors: Niu YP,Xiao MY,Karpefors M,Wigström H

    更新日期:1999-04-06 00:00:00

  • Evidence for a modulatory role of Ih on the firing of a subgroup of midbrain dopamine neurons.

    abstract::A previous investigation has suggested that the hyperpolarization-activated cation current Ih does not contribute to the spontaneous firing of midbrain dopaminergic neurons. This conclusion was reached using Cs(-1). We have re-examined this question with extracellular recordings in slices using the more specific block...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200102120-00015

    authors: Seutin V,Massotte L,Renette MF,Dresse A

    更新日期:2001-02-12 00:00:00

  • Nuclear translocation of DJ-1 protects adult neuronal stem cells in an MPTP mouse model of Parkinson's disease.

    abstract::DJ-1, originally identified as an oncogene product, is involved in multiple processes, including cellular transformation, the oxidative stress response, and transcriptional regulation. We had previously found that DJ-1 was closely associated with the proliferation and differentiation of cultured neuronal stem cells. I...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000956

    authors: Sun Y,Wang Y,Zhao X,Pu X

    更新日期:2018-03-07 00:00:00