Post-test apamin injection suppresses a Kamin-like effect following a learning session in mice.

Abstract:

:BALB/c mice were trained in a partial acquisition session of an appetitive bar-pressing task. They then received an immediate post-acquisition i.p. injection of either saline or apamin 0.2 mg kg-1. Each group was submitted to a retention test that was delayed either 25, 85 or 180 min after initial acquisition. In saline-injected groups retention of the original training was a U-shaped function of intersession interval with a significant drop in performance (Kamin-like effect) at the 85 min time interval. In contrast, at this same time, apamin injected subjects made significantly more reinforced responses than control animals. The suppression of the Kamin-like effect by apamin could be a consequence of an acceleration of the neuronal mechanisms implicated in consolidation and long-term memory storage processes.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Belcadi-Abbassi W,Destrade C

doi

10.1097/00001756-199506090-00016

subject

Has Abstract

pub_date

1995-06-19 00:00:00

pages

1293-6

issue

9

eissn

0959-4965

issn

1473-558X

journal_volume

6

pub_type

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