Abstract:
:BALB/c mice were trained in a partial acquisition session of an appetitive bar-pressing task. They then received an immediate post-acquisition i.p. injection of either saline or apamin 0.2 mg kg-1. Each group was submitted to a retention test that was delayed either 25, 85 or 180 min after initial acquisition. In saline-injected groups retention of the original training was a U-shaped function of intersession interval with a significant drop in performance (Kamin-like effect) at the 85 min time interval. In contrast, at this same time, apamin injected subjects made significantly more reinforced responses than control animals. The suppression of the Kamin-like effect by apamin could be a consequence of an acceleration of the neuronal mechanisms implicated in consolidation and long-term memory storage processes.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Belcadi-Abbassi W,Destrade Cdoi
10.1097/00001756-199506090-00016subject
Has Abstractpub_date
1995-06-19 00:00:00pages
1293-6issue
9eissn
0959-4965issn
1473-558Xjournal_volume
6pub_type
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