Abstract:
:The slow compensatory phases of the vestibulo-ocular reflex (VOR) in the rabbit tend to drift and the drift reverses the direction. This periodic alternating drift (PAD) has two peculiar characteristics: (1) it is induced by sinusoidal vestibular stimulation in naive animals, being evoked immediately after stimulus onset and persisting after the end of stimulation; (2) the peak velocity and period of the drift are dependent on stimulus amplitude. PAD of the rabbit has strong similarities with PAN, a periodic alternating nystagmus observed in humans with cerbellar disorders and in monkeys after nodulo-uvulectomy, although its peak velocity is smaller. It is hypothesized that PAD is due to a slight instability, caused by vestibular stimulation in darkness, of the cerebellar adaptive loop, which exerts a variable gain control on the time constant of the velocity storage integrator.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Ferraresi A,Azzena GB,Troiani Ddoi
10.1097/00001756-200107030-00017subject
Has Abstractpub_date
2001-07-03 00:00:00pages
1847-50issue
9eissn
0959-4965issn
1473-558Xjournal_volume
12pub_type
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