Abstract:
:The first step in olfactory transduction is the recognition of odor molecules by membrane bound receptors belonging to the superfamily of G-protein coupled receptors; other members of this family are involved in neurotransmission. Based on the considerable homology between individual members of this family, we have investigated the ability of well-known neurotransmitter antagonists to block the olfactory response. Adrenergic and muscarinic antagonists were found to block some odor induced currents (45-55%) with an IC50 between 15 and 75 microM. By contrast, antagonists of glutamate and GABA receptors, which do not belong to this receptor superfamily, were ineffective. These results suggest that further pharmacological analysis may be useful for characterizing and classifying the family of odor receptors.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Firestein S,Shepherd GMdoi
10.1097/00001756-199208000-00001subject
Has Abstractpub_date
1992-08-01 00:00:00pages
661-4issue
8eissn
0959-4965issn
1473-558Xjournal_volume
3pub_type
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