Abstract:
:Recently, we have generated transgenic mice (designated as SJLB) carrying human N279K mutant tau, one of the tau mutations causing parkinsonism linked to chromosome 17 (FTDP-17). SJLB mice mimic some features of behavioral alterations and neuronal pathology of patients with Alzheimer's disease. To investigate how tau dysfunctions cause these features, we examined the expression and phosphorylation levels in SJLB mouse hippocampal proteins using a phosphosensor dye in two-dimensional poly acrylamide gel electrophoresis analysis and mass spectrometry. Calreticulin and tubulin beta4 are significantly more phosphorylated, and heat shock cognate 71 kDa protein, tubulin beta2, vacuolar ATP synthase catalytic subunit A, alpha-internexin, alpha-enolase, ubiquitin carboxyl-terminal hydrolase isozyme L1, and complexin-2 are significantly less phosphorylated in SJLB mice than control mice. These proteins could be new targets for elucidating underlying mechanisms and therapeutic intervention in neurodegenerative diseases.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Takano M,Otani M,Sakai A,Kadoyama K,Matsuyama S,Matsumoto A,Takenokuchi M,Sumida M,Taniguchi Tdoi
10.1097/WNR.0b013e328333b0e0subject
Has Abstractpub_date
2009-12-09 00:00:00pages
1648-53issue
18eissn
0959-4965issn
1473-558Xjournal_volume
20pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::The pattern of distribution and co-localization of nitric oxide synthase (NOS) and quinacrine fluorescence (indicative of vesicular adenosine 5'-triphosphate, ATP), and co-localization of NADPH-diaphorase (NADPH-d) activity and NOS-immunoreactivity in the myenteric plexus of pre-term human fetal (6-17 weeks of gestati...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200001170-00002
更新日期:2000-01-17 00:00:00
abstract::The regulation of glucocorticoid receptors and nuclear factor kappaB was evaluated in the spiral ganglion neurons after 4 h of restraint stress in the mouse cochlea. Immediately after restraint stress, glucocorticoid receptor protein expression was not altered in spiral ganglion neurons even though both the plasma cor...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000220131.24468.e7
更新日期:2006-06-26 00:00:00
abstract::Using in situ hybridization histochemistry and immunocytochemistry the induction of immediate early genes (IEGs) was studied in the rat superior cervical ganglion (SCG) after deafferentation, axotomy and sialectomy (removal of the submandibular gland). Control SCGs showed very low levels of IEGs, whereby Fos proteins ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199301000-00009
更新日期:1993-01-01 00:00:00
abstract::The present study examined the sleep-wake cycle effects of microinjections of yohimbine, an adrenergic antagonist, and atropine, a cholinergic antagonist, into the cerebral ventricle of clomipramine-induced depressed rats. Yohimbine microinjection caused a significant reduction in the total duration and the number of ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200209160-00006
更新日期:2002-09-16 00:00:00
abstract::Olfactory cues can elicit intense emotional responses. This study used fMRI in male common marmoset monkeys to identify brain areas associated with sexual arousal in response to odors of ovulating female monkeys. Under light anesthesia, monkeys were secured in a specially designed restrainer and positioned in a 9.4 T ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200107200-00037
更新日期:2001-07-20 00:00:00
abstract::Texas Red-labelled dextran with a mol. wt of 3000 g mol-1, a marker for the extracellular space, was injected unilaterally into the neostriatum of adult rats (0.3-30 micrograms microliter-1) and its distribution evaluated 1 min to 5 h later. Diffusion in the neuropil was observed with clearance starting after 30 min. ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199505090-00014
更新日期:1995-05-09 00:00:00
abstract::Dopaminergic neurotransmission is thought to be involved in reward-related incentive learning and addictive behaviour. Amphetamine will alter glycogen synthase kinase-3β (GSK-3β) activity by increasing dopamine transporter efflux rates. We investigated the hypothesis that Wnt signalling will be altered in rat nucleus ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328357d868
更新日期:2012-10-03 00:00:00
abstract::In the adult brain, neural proliferation is almost absent and neurons are generally not renewed. By contrast, in the olfactory organ, olfactory neurons are produced continuously throughout life. To investigate whether specific cell cycle inhibitors are involved in the control of neural quiescence in adulthood, we comp...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200110080-00029
更新日期:2001-10-08 00:00:00
abstract::In order to accomplish desired movements, the nervous system must specify the movement dynamics: it must provide a signal that compensates for the mechanical constraints encountered during movement. Here we tested whether the population activity of Purkinje cells in the cerebellum specifies the dynamics for pursuit ey...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200004070-00029
更新日期:2000-04-07 00:00:00
abstract::The distribution of inositol 1,4,5-triphosphate 3-kinase (IP3 3-kinase) in the gerbil hippocampus was studied before and after transient ischaemia, by immunohistochemistry and immunoblot with monoclonal antibody to IP3 3-kinase. In control gerbils, intense IP3 3-kinase immunoreactivity was localized in the dendritic f...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199403000-00012
更新日期:1994-03-21 00:00:00
abstract::As manifestations of prion diseases include disturbances of hypothalamic and pituitary functions, we tested the hypothesis that the cellular prion protein (PrPC) has a role as modulator of the hypothalamic-pituitary-adrenal axis. The level of corticosterone and adrenocorticotropic hormone were compared in PrPC null (P...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32830f1e90
更新日期:2008-10-08 00:00:00
abstract::Previous studies suggest that there is a dopamine lowering process during major depressive episodes (MDE). To investigate this, we measured the dopamine transporter binding potential (DAT BP) in the striatum of depressed and healthy subjects using [(11)C]RTI-32 PET. The DAT, a predominantly presynaptic receptor, decre...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200112210-00052
更新日期:2001-12-21 00:00:00
abstract::We used whole-cell recording to identify, for the first time, GABAergic tonic current in subpopulations of substantia gelatinosa neurons in mouse spinal cord slices. Application of the gamma-aminobutyric acid type A receptor antagonist bicuculline revealed tonic currents in 49 of 73 substantia gelatinosa neurons. Thes...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000230515.86090.bc
更新日期:2006-08-21 00:00:00
abstract::Alpha-Synuclein is a major component of neuronal and glial cytoplasmic inclusions in multiple system atrophy (MSA), one of the alpha-synucleinopathies. Recent studies have shown that beta-synuclein, a homolog of alpha-synuclein, inhibits alpha-synuclein aggregation in vitro. We immunohistochemically examined the MSA b...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200310060-00005
更新日期:2003-10-06 00:00:00
abstract::Cisplatin is a widely used chemotherapeutic drug, but one of its side effects is ototoxicity. Epigenetic-related drugs, such as lysine-specific demethylase 1 (LSD1) inhibitors, have been reported to protect against cisplatin-induced hair cell loss by preventing demethylation of histone H3K4 (H3K4me2). However, the pro...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000386
更新日期:2015-06-17 00:00:00
abstract::Little is known regarding opioid receptors in the human cerebellum. The present [11C]diprenorphine PET study investigated opioid receptor binding in the human cerebellum in vivo, and showed a differential binding level in cerebellar cortex, vermis and dentate nuclei. The additional study in vitro of opioid receptors i...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199902250-00032
更新日期:1999-02-25 00:00:00
abstract::Sex differences in event-related potentials were examined in 23 women and 24 men during a mental rotation task. We found an early (130-400 ms) and a late (400-700 ms) ERP mental rotation effect. The late rotation effect, which is thought to indicate the onset of the cognitive process of mental rotation, emerged about ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f519b3
更新日期:2008-02-12 00:00:00
abstract::Male Bengalese finches sing complex song sequences during courtship. To examine the female perception of sequence complexity, we tested female auditory processing with respect to sequential differences in the caudomedial nidopallium and caudomedial mesopallium. Repeated song presentations caused lower expression of th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833730b7
更新日期:2010-04-21 00:00:00
abstract:OBJECTIVE:Cervical spondylotic myelopathy is regarded as a chronic, special incomplete spinal cord injury, so the sensory components transmitted to thalamus decreased after distal spinal cord injury, which lead the disturbance of thalamus-cortex circuits, which might explain the alterations of clinical function of cerv...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001346
更新日期:2020-03-25 00:00:00
abstract::GLAST is a glial glutamate transporter; mRNA for a splice variant, GLAST1a, which lacks exon 3, has previously been identified. To detect GLAST1a protein, we generated antibodies against a peptide sequence encompassing the splice site. We demonstrate by Western blotting and immunocytochemistry the expression of GLAST1...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328010b898
更新日期:2006-12-18 00:00:00
abstract::The gene expression of cholecystokinin (CCK), a neuropeptide with anti-opioid properties, has been reported to be upregulated in some primary sensory neurons after a peripheral nerve lesion. We have recently demonstrated that the upregulation of CCK mRNA is not accompanied by an increased potassium-evoked release CCK-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200101220-00018
更新日期:2001-01-22 00:00:00
abstract::Correcting for eddy currents, movement-induced distortion and gradient inhomogeneities is imperative when processing diffusion MRI (dMRI) data, but is highly computing resource-intensive. Recently, Compute Unified Device Architecture (CUDA) was implemented for the widely-used eddy-correction software, 'eddy', which re...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001475
更新日期:2020-07-10 00:00:00
abstract::To investigate the neurobiological bases of visual hallucinations in dementia with Lewy bodies (DLB), regional cerebral glucose metabolism was compared among three patient groups; DLB with visual hallucinations, DLB without visual hallucinations and Alzheimer's disease (AD) without visual hallucinations. The regional ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199906230-00020
更新日期:1999-06-23 00:00:00
abstract::NMR signal intensities in five regions of the midsagittal corpus callosum were measured in autism patients and normal controls. An age-related increase in signal was observed in the anterior regions in both groups. No significant differences in intensity were detected between the groups. The finding of normal myelinat...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199506090-00006
更新日期:1995-06-19 00:00:00
abstract::Expression of monocarboxylate transporter MCT1 was studied in archival tissues from human CNS using antibodies to the carboxyl-terminal end of MCT1. Sections of neocortex, hippocampus and cerebellum of brains from 10 adult autopsy patients who died from other than CNS disease, and from archival surgical biopsy specime...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200103260-00030
更新日期:2001-03-26 00:00:00
abstract::ErbBs are a family of receptors involved in the trophic maintenance of Schwann cells. Little is known about their expression changes during peripheral nerve regeneration. The aim of this study was thus to investigate variations in ErbBs after end-to-end and end-to-side nerve regeneration in the rat median nerve model....
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32831313ef
更新日期:2008-10-29 00:00:00
abstract::STC-1 cells have been established as an enteroendocrine cell line from the small intestine. By monitoring the level of intracellular Ca using a calcium-imaging technique, cellular responses of intestinal STC-1 cells to compounds of five basic tastants were investigated. Although this cell line was known to respond to ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f242d3
更新日期:2007-12-03 00:00:00
abstract::Systemic administration of DL-fenfluramine (20 mg kg-1), an indirect serotonergic agonist, induced widespread FOS-like protein in the rat caudate putamen (CPu), paraventricular nucleus (PVn) of the hypothalamus and several intralaminar thalamic nuclei. To ascertain whether the dopaminergic nigrostriatal system coordin...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199508000-00021
更新日期:1995-08-21 00:00:00
abstract::A double-stranded DNA end-binding factor with high levels of expression in brain and testis of adult mice was identified as the Ku protein, earlier described as an autoantigen in connective tissue diseases and found to be essential for recombination of the immunoglobulin genes and DNA repair. High Ku levels were found...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199806220-00044
更新日期:1998-06-22 00:00:00
abstract::To investigate the origin of high-frequency somatosensory evoked potential (SEP) components, we recorded median nerve SEPs from the scalp and the depth in six monkeys. Laminar field potentials were analyzed in area 3b (N10; corresponding to human N20) and area 1 (P12; corresponding to human P25). After digital filteri...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200008210-00042
更新日期:2000-08-21 00:00:00