Abstract:
:The present study examined the sleep-wake cycle effects of microinjections of yohimbine, an adrenergic antagonist, and atropine, a cholinergic antagonist, into the cerebral ventricle of clomipramine-induced depressed rats. Yohimbine microinjection caused a significant reduction in the total duration and the number of REM sleep episodes compared to control saline injections. Atropine microinjection caused a significant reduction in the total duration and the number of REM sleep episodes without changing the REM sleep latency compared to control saline microinjection. These results show for the first time that the REM sleep disturbances observed in clomipramine-treatment induced depressed rats can be attenuated by increasing and decreasing the brain noradrenergic and cholinergic activities, respectively.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Mavanji V,Datta Sdoi
10.1097/00001756-200209160-00006subject
Has Abstractpub_date
2002-09-16 00:00:00pages
1603-6issue
13eissn
0959-4965issn
1473-558Xjournal_volume
13pub_type
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