Abstract:
:We used multiple-labelling immunofluorescence, intracellular dye injection, electrophysiological recording and confocal microscopy to examine the expression of immunoreactivity to protein kinase C (PKC) and protein kinase A (PKA) in sympathetic ganglia of guinea-pigs. PKCalpha and PKCgamma were widespread in vasoconstrictor and pilomotor neurons. High levels of PKA RIIalpha and RIIbeta were restricted to neurons that lacked significant expression of PKC, including somatostatin-containing neurons projecting to the gut, and non-noradrenergic vasodilator neurons. In coeliac ganglia, most neurons with PKC contained neuropeptide Y and displayed phasic patterns of action potential firing, often with a long after-hyperpolarization. Tonically firing neurons lacked both neuropeptide Y and PKC. These results show remarkably pathway-specific expression of protein kinases in functionally identified populations of sympathetic neurons.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Gibbins IL,Matthew SE,Jobling Pdoi
10.1097/00001756-199904060-00015subject
Has Abstractpub_date
1999-04-06 00:00:00pages
975-9issue
5eissn
0959-4965issn
1473-558Xjournal_volume
10pub_type
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