Paraventricular nucleus injections of naloxone methiodide inhibit NPY's effects on energy substrate utilization.

Abstract:

:Microinjection of neuropeptide Y (NPY) into the paraventricular nucleus (PVN) of the hypothalamus stimulates eating and increases respiratory quotient. In contrast, administration of opioid receptor antagonists reduces food intake and suppresses NPY-induced feeding. The present study examined whether naloxone methiodide, an opioid antagonist, would suppress the potentiation of NPY on energy substrate utilization, when injected into the PVN. Naloxone methiodide was injected at doses of 0.1 and 1.0 g, 10 min prior to NPY treatment. NPY was administered immediately prior to the start of the nocturnal period and RQ was determined using an open-circuit calorimeter. Doses of 50 and 100 pmol NPY alone evoked reliable increases in RQ within 30min of treatment. Following naloxone methiodide pretreatment, the stimulatory action of NPY was significantly attenuated. These data indicate that opioid receptors in the PVN influence the action of NPY on energy substrate utilization.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Currie PJ,Coscina DV,Moretti J,Avellino MD

doi

10.1097/00001756-200003200-00016

subject

Has Abstract

pub_date

2000-03-20 00:00:00

pages

733-5

issue

4

eissn

0959-4965

issn

1473-558X

journal_volume

11

pub_type

杂志文章
  • Selective suppression of type B monoamine oxidase immunoreactivity in the raphe nuclei following MPTP administration in the cat.

    abstract::Using immunohistochemistry, we investigated in the cat the effects of MPTP, a Parkinsonian syndrome-inducing substance, on brain type B monoamine oxidase (MAO-B) which is responsible for the conversion of MPTP to its neurotoxic product (MPP+). Intraperitoneal administration of MPTP (5 mg kg-1 daily for 5 days) caused ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199501000-00024

    authors: Lin JS,Hou Y,Kitahama K,Jouvet M

    更新日期:1995-01-26 00:00:00

  • Mesencephalic astrocyte-derived neurotrophic factor enhances nigral gamma-aminobutyric acid release.

    abstract::Mesencephalic astrocyte-derived neurotrophic factor (MANF) - one of a new class of astrocyte-derived human proteins--selectively promotes the survival of dopamine neurons of the ventral midbrain. Using the whole-cell clamp technique, we looked for acute effects of MANF on gamma-aminobutyric acid type A (GABAA) recepto...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000201504.23255.bc

    authors: Zhou C,Xiao C,Commissiong JW,Krnjević K,Ye JH

    更新日期:2006-02-27 00:00:00

  • 192 IgG-saporin abolishes p75 neurotrophin receptor immunoreactivity in rat SCN.

    abstract::The rat suprachiasmatic (SCN) contains a dense plexus of low-affinity p75 neurotrophin receptor (p75NTR)-immunoreactivity. In some SCN neurons, p75NTR is co-localized with vasoactive intestinal peptide (VIP). The present study examines the effect of third ventricle administration of 192 IgG-saporin immunotoxin on p75N...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199810050-00012

    authors: Moga MM

    更新日期:1998-10-05 00:00:00

  • Improved fluorophore separation with IMS confocal microscopy.

    abstract::Some of the most extensively used fluorophores for multicolour fluorescence labelling of tissue, such as Lucifer yellow, fluorescein, Cyanine-3.18 and rhodamine, all have the disadvantage of being difficult to separate spectrally due to their broad and overlapping emission spectra. With the intensity-modulated multipl...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199505300-00024

    authors: Carlsson K,Ulfhake B

    更新日期:1995-05-30 00:00:00

  • Neuroactive steroids modulate GABA inhibition of hypothalamic somatostatin release.

    abstract::The reduced steroids 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) and 3 alpha,21-di-hydroxy-5 alpha-pregnan-20-one (allotetrahydroDOC) are potent ligands of GABAA receptors. This study examined the possible modulatory effect of these metabolites on GABA inhibition of somatostatin release in cultured hypot...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199510020-00025

    authors: Tapia-Arancibia L,André M,Belmar J,Arancibia S

    更新日期:1995-10-02 00:00:00

  • Contributions of frontal and medial temporal regions to verbal episodic memory: a PET study.

    abstract::Using PET, subtraction and correlation analysis were jointly employed to determine the specific and complementary contributions of frontal and medial temporal regions to verbal episodic encoding and retrieval processes. Subtraction analysis highlighted prefrontal rCBF increases which were predominantly left-sided duri...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200106130-00044

    authors: Bernard F,Desgranges B,Platel H,Baron JC,Eustache F

    更新日期:2001-06-13 00:00:00

  • In vivo gamma imaging of the secondary tumors of transplanted human fetal striatum neural stem cells-derived primary tumor cells.

    abstract::This study describes gamma-imaging of the secondary tumors from the transplanted human fetal striatum neural stem cells-derived primary tumor cells in nude mice. The subcutaneous primary tumors were detected to express integrin alphavbeta3, and the corresponding cells were isolated and enriched in vitro, then transpla...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e328303c020

    authors: He Q,Liu Z,Jia B,Li X,Shi J,Zhang J,Lan F,Yang Z,Liu Y,Shen L,Wang F

    更新日期:2008-07-02 00:00:00

  • Stimulus novelty and emotion perception: the near absence of habituation in the visual cortex.

    abstract::In rapid serial visual presentation of pictures, an early event-related brain potential component shows enlarged negativity over occipital regions for emotional pictures compared with neutral pictures. The present study examined whether the processing of emotional target pictures varies as a function of stimulus repet...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000203355.88061.c6

    authors: Schupp HT,Stockburger J,Codispoti M,Junghöfer M,Weike AI,Hamm AO

    更新日期:2006-03-20 00:00:00

  • Activity in the human primary motor cortex related to arm and finger movements.

    abstract::With the purpose of mapping representations of the finger and proximal arm in the human primary motor cortex (MI), we measured regional cerebral blood flow (rCBF) in eight right-handed normal volunteers during self-paced finger and proximal arm movements. Each movement activated two different fields in MI, one located...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199501000-00003

    authors: Kawashima R,Itoh H,Ono S,Satoh K,Furumoto S,Gotoh R,Koyama M,Yoshioka S,Takahashi T,Yanagisawa T

    更新日期:1995-01-26 00:00:00

  • The T. cruzi trans-sialidase induces PC12 cell differentiation via MAPK/ERK pathway.

    abstract::The trans-sialidase (TS) of Trypanosoma cruzi induces survival and differentiation of neuronal and glial cells. This mechanism underlying survival is via phosphatidylinositol 3-kinase (PI3K) but how TS promotes neuronal differentiation remained to be determined. Here we show that TS-induced neurite outgrowth in PC12 c...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200112040-00022

    authors: Chuenkova MV,Pereira MA

    更新日期:2001-12-04 00:00:00

  • Slow wave sleep is accompanied by release of certain amino acids in the thalamus of cats.

    abstract::To determine whether EEG synchronization in sleep has a metabolic equivalent, we investigated state-dependent changes in extracellular concentrations of amino acids. In vivo microdialysis studies were performed in the ventroposterolateral (VPL) nuclei of the thalamus of cats during natural slow wave sleep (SWS), wakin...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199703240-00025

    authors: Kékesi KA,Dobolyi A,Salfay O,Nyitrai G,Juhász G

    更新日期:1997-03-24 00:00:00

  • Distribution of Smoothened at hippocampal mossy fiber synapses.

    abstract::The seven-transmembrane receptor Smoothened is essential for hedgehog signal transduction. In adulthood, the highest density of Smoothened mRNA is found in the granule cell layer of the dentate gyrus. There, Smoothened expression is regulated by the synaptic activity involving the glutamatergic transmission. The preci...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32801421ce

    authors: Masdeu C,Bernard V,Faure H,Traiffort E,Ruat M

    更新日期:2007-03-05 00:00:00

  • Dynamic reorganization of referred sensations by movements of phantom limbs.

    abstract::After amputation of an arm the sensory map of the body changes radically, causing the sensory input from face to 'invade' the original hand area in the brain. As a result, touching the face of the amputee evokes tactile sensations on the phantom. These sensory referrals from the face to phantom hand occur in a stable,...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32833be9ab

    authors: Ramachandran VS,Brang D,McGeoch PD

    更新日期:2010-07-14 00:00:00

  • Characterization of labeled neural progenitor cells for magnetic targeting.

    abstract::For many diseases and injuries of the central nervous system, transplantation of neural progenitor cells is being evaluated as a possible treatment option. Although local, intravenous and subarachnoid injections have been reported as administration methods of neural progenitor cells, each of these methods has limitati...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Hamasaki T,Tanaka N,Ishida O,Yanada S,Kamei N,Fujiwara Y,Nishida K,Nakanishi K,Sharman P,Kawamata S,Ochi M

    更新日期:2005-10-17 00:00:00

  • Effects of Panax notoginseng saponin on α, β, and γ secretase involved in Aβ deposition in SAMP8 mice.

    abstract::Our previous studies have shown that Panax notoginseng saponins (PNS) play a protective role in learning dysfunction of Alzheimer's disease, inhibit the deposition of Aβ1-40 and Aβ1-42, and reduce the content of App in the brain of SAMP8. In this study, we aimed to investigate the effects of PNS on α, β, and γ secreta...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000048

    authors: Huang J,Wu D,Wang J,Li F,Lu L,Gao Y,Zhong Z

    更新日期:2014-01-22 00:00:00

  • pH transients due to monosynaptic activation of GABAA receptors in rat hippocampal slices.

    abstract::Extracellular pH transients were evoked in rat hippocampal brain slices by activation of a monosynaptic inhibitory pathway following pharmacological blockade of glutaminergic transmission. Repetitive stimulation in stratum radiatum near the recording site in stratum pyramidale evoked an immediate alkaline shift which ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199201000-00028

    authors: Kaila K,Paalasmaa P,Taira T,Voipio J

    更新日期:1992-01-01 00:00:00

  • Birdsong neurolinguistics: songbird context-free grammar claim is premature.

    abstract::There are remarkable behavioral, neural, and genetic similarities between song learning in songbirds and speech acquisition in human infants. Previously, we have argued that this parallel cannot be extended to the level of sentence syntax. Although birdsong can indeed have a complex structure, it lacks the combinatori...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32834f1765

    authors: Beckers GJ,Bolhuis JJ,Okanoya K,Berwick RC

    更新日期:2012-02-15 00:00:00

  • N-methyl D-aspartate induced mechanical allodynia is blocked by nitric oxide synthase and cyclooxygenase-2 inhibitors.

    abstract::The role of spinal NMDA receptors in mechanical nociceptive processing was assessed in sheep. Intrathecal NMDA (2 nmol-1 micromol) produced a significant reduction in mechanical withdrawal thresholds. This effect was attenuated by pretreatment with the NMDA receptor antagonist MK801 (100 nmol), the cyclooxygenase-2 (C...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199902250-00002

    authors: Dolan S,Nolan AM

    更新日期:1999-02-25 00:00:00

  • Presynaptic exocytosis regulates NR2A mRNA expression in cultured neocortical neurones.

    abstract::N-methyl-D-aspartate (NMDA) receptors are hetero-oligomeric receptor-channel complexes composed of NR1 and NR2 subunits. Subunit composition determines the properties of NMDA receptor subtypes. However, the molecular mechanisms regulating their subunit composition are unknown. Using reverse transcription (RT)-competit...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199712010-00015

    authors: Hoffmann H,Hatt H,Gottmann K

    更新日期:1997-12-01 00:00:00

  • Gender differences in cerebral ascorbate levels and ascorbate loss in ischemia.

    abstract::Ascorbate and glutathione (GSH) are the primary water-soluble antioxidants in the CNS. Oxidative stress, sometimes indicated by loss of these antioxidants, has been linked to several clinical and experimental conditions, including cerebral ischemia. These conditions are also gender-linked, with greater incidence or se...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199507310-00005

    authors: Ferris DC,Kume-Kick J,Russo-Menna I,Rice ME

    更新日期:1995-07-31 00:00:00

  • Change of vanilloid receptor 1 expression in dorsal root ganglion and spinal dorsal horn during inflammatory nociception induced by complete Freund's adjuvant in rats.

    abstract::The present study aimed to systematically observe the change of vanilloid receptor 1 (VR1) during inflammatory nociception induced by intraplantar injection of complete Freund's adjuvant (CFA) into the left hind paw in rats. Hot plate latency (HPL) was used to evaluate resulting thermal hyperalgesia and immunohistoche...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200403220-00016

    authors: Luo H,Cheng J,Han JS,Wan Y

    更新日期:2004-03-22 00:00:00

  • NMDA receptor blockade reverses motor response alterations induced by levodopa.

    abstract::Motor fluctuations that ultimately complicate the response of most parkinsonian patients to levodopa therapy might represent a form of behavioral or neuronal plasticity. Since various forms of neuronal plasticity appear to be mediated by glutamate transmission through the N-methyl-D-aspartate (NMDA) receptor, the effe...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199412000-00045

    authors: Engber TM,Papa SM,Boldry RC,Chase TN

    更新日期:1994-12-20 00:00:00

  • Expression of the kallikrein gene family in normal and Alzheimer's disease brain.

    abstract::The human kallikrein gene family consists of 15 serine proteases. We examined the expression of the kallikrein genes in human cerebral cortex and hippocampus by RT-PCR and compared their expression between Alzheimer's disease (AD) and control tissue. KLK1, 4, 5, 6, 7, 8, 10, 11, 13 and 14 are expressed in both cerebra...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200108280-00031

    authors: Shimizu-Okabe C,Yousef GM,Diamandis EP,Yoshida S,Shiosaka S,Fahnestock M

    更新日期:2001-08-28 00:00:00

  • Three novel connexin26 gene mutations in autosomal recessive non-syndromic deafness.

    abstract::Since the first identification of an association between mutations in the connexin26 (Cx26) gene and autosomal recessive non-syndromic deafness it has been shown that several mutations in this gene cause recessive, sporadic, and dominant non-syndromic deafness. Three novel mutations in the Cx26 gene were identified in...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199906230-00010

    authors: Fuse Y,Doi K,Hasegawa T,Sugii A,Hibino H,Kubo T

    更新日期:1999-06-23 00:00:00

  • Voltage-activated intracellular calcium transients in thalamic relay cells and interneurons.

    abstract::The dynamics of intracellular calcium concentration ([Ca2+]i) following activation of low voltage-activated (LVA) and high voltage-activated (HVA) Ca2+ currents were studied in identified relay neurons and interneurons of the rat dorsal lateral geniculate nucleus (LGNd) in situ using Ca2+ imaging and patch-clamp techn...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199707280-00001

    authors: Munsch T,Budde T,Pape HC

    更新日期:1997-07-28 00:00:00

  • Successful outcomes of cochlear implantation in long-term unilateral deafness: brain plasticity?

    abstract::To investigate the implications of duration of deafness in the rehabilitation of unilateral deafness utilizing cochlear implantation. From the ongoing prospective cochlear implantation in unilateral deafness study, we looked at five adults who received a cochlear implant for long-term unilateral deafness. Speech perce...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3283642a93

    authors: Távora-Vieira D,Boisvert I,McMahon CM,Maric V,Rajan GP

    更新日期:2013-09-11 00:00:00

  • Effects of baicalin on diabetic neuropathic pain involving transient receptor potential vanilloid 1 in the dorsal root ganglia of rats.

    abstract::Diabetic peripheral neuropathy is the most common complication of diabetes mellitus and leads to sensory symptoms, including diabetic neuropathic pain (DNP). DNP is a major public health problem because it has a considerable impact on life quality of diabetes mellitus patients. Therefore, development of novel effectiv...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001138

    authors: Li P,Xiong DL,Sun WP,Xu SY

    更新日期:2018-12-05 00:00:00

  • Sex differences in functional activation patterns revealed by increased emotion processing demands.

    abstract::Two [O(15)] PET studies assessed sex differences regional brain activation in the recognition of emotional stimuli. Study I revealed that the recognition of emotion in visual faces resulted in bilateral frontal activation in women, and unilateral right-sided activation in men. In study II, the complexity of the emotio...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200402090-00001

    authors: Hall GB,Witelson SF,Szechtman H,Nahmias C

    更新日期:2004-02-09 00:00:00

  • Cl(-)-dependent excitotoxicity is associated with 3H2O influx in chick embryonic retina.

    abstract::The aim of this study was to show that Cl(-)-dependent excitotoxicity, with its characteristic cell swelling, involves actual water influx into the intracellular compartment. Taking advantage of the Ca2+ omission paradigm of Cl(-)-dependent excitotoxicity, in the chick embryonic neural retina ex vivo, which is associa...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200011270-00037

    authors: Burgos JS,Barat A,Ramirez G

    更新日期:2000-11-27 00:00:00

  • Free radical scavenger protects against inner hair cell loss after cochlear ischemia.

    abstract::We investigated the protective effects of edaravone, a free radical scavenger, against ischemic damage of inner hair cells (IHCs) in gerbils. Cochlear ischemia was induced in the animals by occluding the vertebral arteries bilaterally for 15 min. Edaravone (1 mg/kg, i.v.) or saline was administered 1 h after ischemia....

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200310060-00025

    authors: Maetani T,Hakuba N,Taniguchi M,Hyodo J,Shimizu Y,Gyo K

    更新日期:2003-10-06 00:00:00