Paraventricular nucleus injections of naloxone methiodide inhibit NPY's effects on energy substrate utilization.


:Microinjection of neuropeptide Y (NPY) into the paraventricular nucleus (PVN) of the hypothalamus stimulates eating and increases respiratory quotient. In contrast, administration of opioid receptor antagonists reduces food intake and suppresses NPY-induced feeding. The present study examined whether naloxone methiodide, an opioid antagonist, would suppress the potentiation of NPY on energy substrate utilization, when injected into the PVN. Naloxone methiodide was injected at doses of 0.1 and 1.0 g, 10 min prior to NPY treatment. NPY was administered immediately prior to the start of the nocturnal period and RQ was determined using an open-circuit calorimeter. Doses of 50 and 100 pmol NPY alone evoked reliable increases in RQ within 30min of treatment. Following naloxone methiodide pretreatment, the stimulatory action of NPY was significantly attenuated. These data indicate that opioid receptors in the PVN influence the action of NPY on energy substrate utilization.






Currie PJ,Coscina DV,Moretti J,Avellino MD




Has Abstract


2000-03-20 00:00:00












  • Selective suppression of type B monoamine oxidase immunoreactivity in the raphe nuclei following MPTP administration in the cat.

    abstract::Using immunohistochemistry, we investigated in the cat the effects of MPTP, a Parkinsonian syndrome-inducing substance, on brain type B monoamine oxidase (MAO-B) which is responsible for the conversion of MPTP to its neurotoxic product (MPP+). Intraperitoneal administration of MPTP (5 mg kg-1 daily for 5 days) caused ...


    pub_type: 杂志文章


    authors: Lin JS,Hou Y,Kitahama K,Jouvet M

    更新日期:1995-01-26 00:00:00

  • Mesencephalic astrocyte-derived neurotrophic factor enhances nigral gamma-aminobutyric acid release.

    abstract::Mesencephalic astrocyte-derived neurotrophic factor (MANF) - one of a new class of astrocyte-derived human proteins--selectively promotes the survival of dopamine neurons of the ventral midbrain. Using the whole-cell clamp technique, we looked for acute effects of MANF on gamma-aminobutyric acid type A (GABAA) recepto...


    pub_type: 杂志文章


    authors: Zhou C,Xiao C,Commissiong JW,Krnjević K,Ye JH

    更新日期:2006-02-27 00:00:00

  • 192 IgG-saporin abolishes p75 neurotrophin receptor immunoreactivity in rat SCN.

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    pub_type: 杂志文章


    authors: Moga MM

    更新日期:1998-10-05 00:00:00

  • Improved fluorophore separation with IMS confocal microscopy.

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    pub_type: 杂志文章


    authors: Carlsson K,Ulfhake B

    更新日期:1995-05-30 00:00:00

  • Neuroactive steroids modulate GABA inhibition of hypothalamic somatostatin release.

    abstract::The reduced steroids 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) and 3 alpha,21-di-hydroxy-5 alpha-pregnan-20-one (allotetrahydroDOC) are potent ligands of GABAA receptors. This study examined the possible modulatory effect of these metabolites on GABA inhibition of somatostatin release in cultured hypot...


    pub_type: 杂志文章


    authors: Tapia-Arancibia L,André M,Belmar J,Arancibia S

    更新日期:1995-10-02 00:00:00

  • Contributions of frontal and medial temporal regions to verbal episodic memory: a PET study.

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    pub_type: 杂志文章


    authors: Bernard F,Desgranges B,Platel H,Baron JC,Eustache F

    更新日期:2001-06-13 00:00:00

  • In vivo gamma imaging of the secondary tumors of transplanted human fetal striatum neural stem cells-derived primary tumor cells.

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    pub_type: 杂志文章


    authors: He Q,Liu Z,Jia B,Li X,Shi J,Zhang J,Lan F,Yang Z,Liu Y,Shen L,Wang F

    更新日期:2008-07-02 00:00:00

  • Stimulus novelty and emotion perception: the near absence of habituation in the visual cortex.

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    pub_type: 杂志文章


    authors: Schupp HT,Stockburger J,Codispoti M,Junghöfer M,Weike AI,Hamm AO

    更新日期:2006-03-20 00:00:00

  • Activity in the human primary motor cortex related to arm and finger movements.

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    pub_type: 杂志文章


    authors: Kawashima R,Itoh H,Ono S,Satoh K,Furumoto S,Gotoh R,Koyama M,Yoshioka S,Takahashi T,Yanagisawa T

    更新日期:1995-01-26 00:00:00

  • The T. cruzi trans-sialidase induces PC12 cell differentiation via MAPK/ERK pathway.

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    pub_type: 杂志文章


    authors: Chuenkova MV,Pereira MA

    更新日期:2001-12-04 00:00:00

  • Slow wave sleep is accompanied by release of certain amino acids in the thalamus of cats.

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    pub_type: 杂志文章


    authors: Kékesi KA,Dobolyi A,Salfay O,Nyitrai G,Juhász G

    更新日期:1997-03-24 00:00:00

  • Distribution of Smoothened at hippocampal mossy fiber synapses.

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    pub_type: 杂志文章


    authors: Masdeu C,Bernard V,Faure H,Traiffort E,Ruat M

    更新日期:2007-03-05 00:00:00

  • Dynamic reorganization of referred sensations by movements of phantom limbs.

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    pub_type: 杂志文章


    authors: Ramachandran VS,Brang D,McGeoch PD

    更新日期:2010-07-14 00:00:00

  • Characterization of labeled neural progenitor cells for magnetic targeting.

    abstract::For many diseases and injuries of the central nervous system, transplantation of neural progenitor cells is being evaluated as a possible treatment option. Although local, intravenous and subarachnoid injections have been reported as administration methods of neural progenitor cells, each of these methods has limitati...


    pub_type: 杂志文章


    authors: Hamasaki T,Tanaka N,Ishida O,Yanada S,Kamei N,Fujiwara Y,Nishida K,Nakanishi K,Sharman P,Kawamata S,Ochi M

    更新日期:2005-10-17 00:00:00

  • Effects of Panax notoginseng saponin on α, β, and γ secretase involved in Aβ deposition in SAMP8 mice.

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    pub_type: 杂志文章


    authors: Huang J,Wu D,Wang J,Li F,Lu L,Gao Y,Zhong Z

    更新日期:2014-01-22 00:00:00

  • pH transients due to monosynaptic activation of GABAA receptors in rat hippocampal slices.

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    pub_type: 杂志文章


    authors: Kaila K,Paalasmaa P,Taira T,Voipio J

    更新日期:1992-01-01 00:00:00

  • Birdsong neurolinguistics: songbird context-free grammar claim is premature.

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    pub_type: 杂志文章


    authors: Beckers GJ,Bolhuis JJ,Okanoya K,Berwick RC

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  • N-methyl D-aspartate induced mechanical allodynia is blocked by nitric oxide synthase and cyclooxygenase-2 inhibitors.

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    pub_type: 杂志文章


    authors: Dolan S,Nolan AM

    更新日期:1999-02-25 00:00:00

  • Presynaptic exocytosis regulates NR2A mRNA expression in cultured neocortical neurones.

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    pub_type: 杂志文章


    authors: Hoffmann H,Hatt H,Gottmann K

    更新日期:1997-12-01 00:00:00

  • Gender differences in cerebral ascorbate levels and ascorbate loss in ischemia.

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    pub_type: 杂志文章


    authors: Ferris DC,Kume-Kick J,Russo-Menna I,Rice ME

    更新日期:1995-07-31 00:00:00

  • Change of vanilloid receptor 1 expression in dorsal root ganglion and spinal dorsal horn during inflammatory nociception induced by complete Freund's adjuvant in rats.

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    pub_type: 杂志文章


    authors: Luo H,Cheng J,Han JS,Wan Y

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  • NMDA receptor blockade reverses motor response alterations induced by levodopa.

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    pub_type: 杂志文章


    authors: Engber TM,Papa SM,Boldry RC,Chase TN

    更新日期:1994-12-20 00:00:00

  • Expression of the kallikrein gene family in normal and Alzheimer's disease brain.

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    pub_type: 杂志文章


    authors: Shimizu-Okabe C,Yousef GM,Diamandis EP,Yoshida S,Shiosaka S,Fahnestock M

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  • Three novel connexin26 gene mutations in autosomal recessive non-syndromic deafness.

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    pub_type: 杂志文章


    authors: Fuse Y,Doi K,Hasegawa T,Sugii A,Hibino H,Kubo T

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  • Voltage-activated intracellular calcium transients in thalamic relay cells and interneurons.

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    pub_type: 杂志文章


    authors: Munsch T,Budde T,Pape HC

    更新日期:1997-07-28 00:00:00

  • Successful outcomes of cochlear implantation in long-term unilateral deafness: brain plasticity?

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    pub_type: 杂志文章


    authors: Távora-Vieira D,Boisvert I,McMahon CM,Maric V,Rajan GP

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  • Effects of baicalin on diabetic neuropathic pain involving transient receptor potential vanilloid 1 in the dorsal root ganglia of rats.

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    pub_type: 杂志文章


    authors: Li P,Xiong DL,Sun WP,Xu SY

    更新日期:2018-12-05 00:00:00

  • Sex differences in functional activation patterns revealed by increased emotion processing demands.

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    pub_type: 杂志文章


    authors: Hall GB,Witelson SF,Szechtman H,Nahmias C

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    pub_type: 杂志文章


    authors: Burgos JS,Barat A,Ramirez G

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  • Free radical scavenger protects against inner hair cell loss after cochlear ischemia.

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    pub_type: 杂志文章


    authors: Maetani T,Hakuba N,Taniguchi M,Hyodo J,Shimizu Y,Gyo K

    更新日期:2003-10-06 00:00:00