Abstract:
:In isolated neurons of Helix pomatia, a two-microelectrode voltage clamp technique was used to study the effect of Fe3+ on voltage-gated potassium currents: a low-threshold fast-inactivating current (I(A)) and a high threshold slow-inactivating current with calcium-dependent (I(C)) and calcium-independent (I(DR)) components. Extracellular application of FeCl3 rapidly, reversibly and dose-dependently reduced the amplitude of I(A), I(C) and I(DR) with IC50 values of 49, 45 and 70 microM, respectively. Complete inhibition of K+ currents was reached at 100-500 microM Fe3+. The threshold for the total slow-inactivating potassium current shifted in a positive direction by 10-30 mV in the presence of Fe3+ (50-300 microM). Our work is the first demonstration of the strong blocking effect of Fe3+ on potassium currents of neuronal membrane.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Bukanova JV,Solntseva EI,Skrebitsky VGdoi
10.1097/WNR.0b013e3282c48c1csubject
Has Abstractpub_date
2007-08-27 00:00:00pages
1395-8issue
13eissn
0959-4965issn
1473-558Xpii
00001756-200708270-00019journal_volume
18pub_type
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