Transient expression of the NR2C subunit of the NMDA receptor in developing rat brain.

abstract：:Sciatic nerve resection leaving a 15 mm gap could not be repaired by bridging the stumps with a silicone tube prefilled with a laminin gel. However, when purified olfactory ensheathing cells (EC) were added to the gel filling the tube, successful axonal regeneration was observed in 50% of rats. With 12 mm gaps, regene...

journal_title：Neuroreport

authors： Verdú E,Navarro X,Gudiño-Cabrera G,Rodríguez FJ,Ceballos D,Valero A,Nieto-Sampedro M

更新日期：1999-04-06 00:00:00

abstract：:The present study used scores from Seligman's Attribution Style Questionnaire and [15O] water positron emission tomographic measurements of regional cerebral blood flow (rCBF) to investigate the relation between individual differences in dispositional pessimism and amygdala activity. During scanning 13 healthy non-sna...

journal_title：Neuroreport

authors： Fischer H,Tillfors M,Furmark T,Fredrikson M

更新日期：2001-06-13 00:00:00

abstract：:This study examined the potential of embryonic stem cell-derived neurons as transplants for cell therapy for the primary loss of spiral ganglion neurons. To assess the ability of embryonic stem cell-derived neurons for innervation into auditory epithelia, they were cocultured with auditory epithelium explants of mice ...

journal_title：Neuroreport

authors： Matsumoto M,Nakagawa T,Higashi T,Kim TS,Kojima K,Kita T,Sakamoto T,Ito J

更新日期：2005-05-31 00:00:00

abstract：:Peripheral nervous system injury may be corrected by surgical repair, but in many cases this is not possible and will result in loss of motor and sensory function. Schwann cells provide many neurotrophic signals essential for axon regeneration and immediately after injury inflammatory cytokines are released necessary ...

journal_title：Neuroreport

authors： Teare KA,Pearson RG,Shakesheff KM,Haycock JW

更新日期：2004-03-01 00:00:00

abstract：:The present study examined the neuroprotective effects of choroid plexus isolated from adult rats and encapsulated within alginate microcapsules. In vitro, conditioned media from cultured choroid plexus produced a marked, dose-dependent protection of embryonic cortical neurons against serum deprivation-induced cell de...

journal_title：Neuroreport

authors： Borlongan CV,Skinner SJ,Geaney M,Vasconcellos AV,Elliott RB,Emerich DF

更新日期：2004-07-19 00:00:00

abstract：:The effects of interleukin-1beta in the paraventricular nucleus or caudal arcuate nucleus on hypertensive and tachycardiac responses induced by excitation of the central amygdaloid nucleus were studied. We observed that microinjection of sodium glutamate into central amygdaloid nucleus resulted in hypertension and tac...

journal_title：Neuroreport

authors： Lu Y,Chen W,Zou CJ

更新日期：2002-03-25 00:00:00

abstract：:Age-related depletion of androgens in men results in functional impairments in androgen-responsive tissues, such as the brain, resulting in increased risk for Alzheimer's disease. To investigate the relationship between normal age-related hormone loss and Alzheimer's disease risk, we evaluated the brain and serum leve...

journal_title：Neuroreport

authors： Rosario ER,Chang L,Beckett TL,Carroll JC,Paul Murphy M,Stanczyk FZ,Pike CJ

更新日期：2009-11-25 00:00:00

abstract：:Adeno-associated virus type2 (AAV-2) binds to heparan-sulfate proteoglycans on the cell surface. In vivo, attachment of viral particles to cells adjacent to the injection tract limits the distribution of AAV-2 when infused into the CNS parenchyma and heparin co-infusion might decrease the binding of AAV-2 particles to...

journal_title：Neuroreport

authors： Nguyen JB,Sanchez-Pernaute R,Cunningham J,Bankiewicz KS

更新日期：2001-07-03 00:00:00

abstract：:Recent study has demonstrated that high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) have the same effect to alleviate β-amyloid pathology in the hippocampus of APPswe/PS1dE9 (APP/PS1) mice. Activation of nucleotide binding and oligomerization domain-like receptor family pyrin d...

journal_title：Neuroreport

authors： Liang F,Huang T,Li B,Zhao Y,Zhang X,Xu B

更新日期：2020-03-25 00:00:00

abstract：:Evidence of glutamatergic dysfunction in schizophrenia associated with the N-methyl-D-aspartate receptor has historically demonstrated changes primarily attributable to neurons. We propose an astrocytic component to N-methyl-D-aspartate receptor dysfunction in this illness. We studied the expression of serine racemase...

journal_title：Neuroreport

authors： Steffek AE,Haroutunian V,Meador-Woodruff JH

更新日期：2006-07-31 00:00:00

abstract：:We examined the cortical areas showing increased activation related to axis orientation discrimination in hand movement and perception by positron emission tomography (PET) in right-handed normal human subjects while they performed a hand orientation (HO) task and an orientation discrimination (OD) task. In the OD tas...

journal_title：Neuroreport

authors： Taira M,Kawashima R,Inoue K,Fukuda H

更新日期：1998-01-26 00:00:00

abstract：:The pathogenesis of amyotrophic lateral sclerosis remains poorly understood, but microglial and astroglial activation are thought to contribute to motor neuron death. Evidence suggests that matrix metalloproteinase-9 (MMP-9) is a mediator of this deleterious effect. In this study, we evaluated the effect of MMP-9 on t...

journal_title：Neuroreport

authors： Dewil M,Schurmans C,Starckx S,Opdenakker G,Van Den Bosch L,Robberecht W

更新日期：2005-03-15 00:00:00

abstract：:We investigated the influence of noise on brain responses to spoken sentences in MEG. Sixteen subjects had to listen to acoustically presented sentences and judge their syntactic correctness. Sentences were either presented on a silent background or with noise. Noise had differential effects on early auditory and synt...

journal_title：Neuroreport

authors： Herrmann CS,Oertel U,Wang Y,Maess B,Friederici AD

更新日期：2000-02-07 00:00:00

abstract：:Galanin, oxytocin and cholecystokinin (CCK) are peptides that influence feeding behaviour. Galanin has been found to stimulate food intake and oxytocin and CCK have been suggested to be satiety agents. The present study was performed in order to investigate if galanin influences the secretion of oxytocin and CCK as a ...

journal_title：Neuroreport

authors： Björkstrand E,Hulting AL,Meister B,Uvnäs-Moberg K

更新日期：1993-01-01 00:00:00

abstract：:After learning position discrimination in a T-maze water escape task, rats had either a 2 mm section of the middle cerebral artery removed bilaterally (bMCA) or they received a sham operation. Beginning on the day of surgery either total brain gangliosides (50 mg kg-1) or saline were administered daily for five days. ...

journal_title：Neuroreport

authors： McDaniel WF,Fjordbak T,Schmidt MS,Tucker JC,Davis BK

更新日期：1991-11-01 00:00:00

abstract：:Voltage-gated sodium channels (VGSCs) are concentrated in the postsynaptic membrane at the adult rat neuromuscular junction (NMJ). We have used immunolabelling to determine the pattern of initial VGSC accumulation during development. At birth, but not 3 days before, VGSC labelling is detectable at the NMJ and in the p...

journal_title：Neuroreport

authors： Wood SJ,Shewry K,Young C,Slater CR

更新日期：1998-06-22 00:00:00

abstract：:Three forms of non-injurious ischemic preconditioning were tested for their effects on endogenous antioxidant activity and subsequent ischemic injury. Test ischemia alone, consisting of 1 h occlusion of both carotid arteries (BCAs) and one middle cerebral artery (MCA), elicited an average volume of cerebral infarction...

journal_title：Neuroreport

authors： Toyoda T,Kassell NF,Lee KS

更新日期：1997-03-03 00:00:00

abstract：:Humans are able to correct an ongoing movement very quickly in response to a suddenly moving target. Such fast responses possibly bypass the motor cortex and if so, one would expect that damage to the motor cortex would not greatly affect them. A group of children with congenital spastic hemiplegia were asked to move ...

journal_title：Neuroreport

authors： Smits-Engelsman BC,Rameckers EE,Duysens J

更新日期：2009-01-07 00:00:00

abstract：:The serum-free mouse embryo (SFME) cell line, derived from 16-day-old mouse embryos in medium in which serum was replaced by growth factors and other supplements, has been cultured for more than 200 generations. SFME cells are nontumorigenic, lack gross chromosomal abnormalities, and display characteristics of CNS pro...

journal_title：Neuroreport

authors： Loo DT,Althoen MC,Cotman CW

更新日期：1994-08-15 00:00:00

abstract：:Although citral, which is abundantly present in lemongrass, has various actions including antinociception, how citral affects synaptic transmission has not been examined as yet. Citral activates in heterologous cells transient receptor potential vanilloid-1, ankyrin-1, and melastatin-8 (TRPV1, TRPA1, and TRPM8, respec...

journal_title：Neuroreport

authors： Zhu L,Fujita T,Jiang CY,Kumamoto E

更新日期：2016-02-10 00:00:00

abstract：:The objective of this study was to investigate the effects of long-term mental abacus calculation training (MACT) on children's spatial attention orientation. Fifteen children with intensive MACT (MACT group) and 15 children without MACT (non-MACT group) were selected. The two groups of children were matched in age, s...

journal_title：Neuroreport

authors： Liu X,Sun Y

更新日期：2017-01-01 00:00:00

abstract：:There is no unifying hypothesis to account for the anatomical distribution of neuropathology, the involvement of beta-amyloid precursor protein (beta APP) and the role of increasing age in triggering the Alzheimer disease process. We report here that layer II pre-alpha neurones in transentorhinal and entorhinal cortex...

journal_title：Neuroreport

authors： Roberts GW,Nash M,Ince PG,Royston MC,Gentleman SM

更新日期：1993-01-01 00:00:00

abstract：:The ability to attribute mental states to others ('theory of mind') pervades normal social interaction and is impaired in autistic individuals. In a previous positron emission tomography scan study of normal volunteers, performing a 'theory of mind' task was associated with activity in left medial prefrontal cortex. W...

journal_title：Neuroreport

authors： Happé F,Ehlers S,Fletcher P,Frith U,Johansson M,Gillberg C,Dolan R,Frackowiak R,Frith C

更新日期：1996-12-20 00:00:00

abstract：OBJECTIVE:Cervical spondylotic myelopathy is regarded as a chronic, special incomplete spinal cord injury, so the sensory components transmitted to thalamus decreased after distal spinal cord injury, which lead the disturbance of thalamus-cortex circuits, which might explain the alterations of clinical function of cerv...

journal_title：Neuroreport

authors： Peng X,Tan Y,He L,Ou Y

更新日期：2020-03-25 00:00:00

abstract：:It has been suggested that lower motor neurons containing calcium-binding proteins (CBP) may be resistant to degeneration in motor neuron disease. The testing of this hypothesis is hampered by lack of comprehensive information regarding the presence of CBPs in motor neurons. To address this shortcoming, we investigate...

journal_title：Neuroreport

authors： Fahandejsaadi A,Leung E,Rahaii R,Bu J,Geula C

更新日期：2004-03-01 00:00:00

abstract：:GABAA receptors mediate the inhibition of somatostatin release in hypothalamic neurones. To study the possible effect of GABA on somatostatin biosynthesis, somatostatin and preprosomatostatin mRNA levels were evaluated after exposure of hypothalamic neurones to muscimol or bicuculline. Muscimol (50 microM) decreased p...

journal_title：Neuroreport

authors： Rage F,Jalaguier S,Rougeot C,Tapia-Arancibia L

更新日期：1993-03-01 00:00:00

abstract：:Upon perfusion with Mg2+-free artificial cerebrospinal fluid (ACSF) organotypic hippocampal slice cultures develop seizure-like events and tonic recurrent discharges in which areas CA3 and CA1 and, in contrast to acute slices, also the dentate gyrus (DG) participate. Using the fluorescent dye propidium iodide (PI) we ...

journal_title：Neuroreport

authors： Kovács R,Gutiérrez R,Kivi A,Schuchmann S,Gabriel S,Heinemann U

更新日期：1999-02-05 00:00:00

abstract：:Activated NF-kappaB contributes to cerebral infarction by triggering a neuro-inflammatory response. Rats subjected to 90min middle cerebral artery occlusion developed a cortical infarct of 20+/-4% of hemispheric volume (n = 8). Treatment with the proteasome inhibitor CVT-634 resulted in a significantly smaller infarct...

journal_title：Neuroreport

authors： Buchan AM,Li H,Blackburn B

更新日期：2000-02-07 00:00:00

abstract：:The functions of the fields of the mammalian auditory cortex in sound perception and recognition are unknown. We used Fos (a protein of the inducible immediate-early gene c-fos) as a cellular marker of activated brain areas to show in the mouse (Mus domesticus) that sound is processed differentially in auditory cortic...

journal_title：Neuroreport

authors： Fichtel I,Ehret G

更新日期：1999-08-02 00:00:00

abstract：:Although decision-making is typically seen as a rational process, emotions play a role in tasks that include unfairness. Recently, activation in the right dorsolateral prefrontal cortex during offers experienced as unfair in the Ultimatum Game was suggested to subserve goal maintenance in this task. This is restricted...

journal_title：Neuroreport

authors： van 't Wout M,Kahn RS,Sanfey AG,Aleman A

更新日期：2005-11-07 00:00:00