Age-related changes in serum and brain levels of androgens in male Brown Norway rats.

Abstract:

:Age-related depletion of androgens in men results in functional impairments in androgen-responsive tissues, such as the brain, resulting in increased risk for Alzheimer's disease. To investigate the relationship between normal age-related hormone loss and Alzheimer's disease risk, we evaluated the brain and serum levels of androgens and estrogen in aging male rats. We observed that increasing age was associated with a significant reduction in brain levels of the potent androgen dihydrotestosterone and a trend toward decreased testosterone. Brain levels of soluble beta-amyloid were observed to increase with age. Collectively, these findings highlight differences in brain and circulating levels of androgens during aging, and identify an inverse correlation with beta-amyloid levels that may be relevant to Alzheimer's disease risk.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Rosario ER,Chang L,Beckett TL,Carroll JC,Paul Murphy M,Stanczyk FZ,Pike CJ

doi

10.1097/WNR.0b013e328331f968

subject

Has Abstract

pub_date

2009-11-25 00:00:00

pages

1534-7

issue

17

eissn

0959-4965

issn

1473-558X

journal_volume

20

pub_type

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