Abstract:
:The present study aimed to systematically observe the change of vanilloid receptor 1 (VR1) during inflammatory nociception induced by intraplantar injection of complete Freund's adjuvant (CFA) into the left hind paw in rats. Hot plate latency (HPL) was used to evaluate resulting thermal hyperalgesia and immunohistochemistry to observe VR1 expression in dorsal root ganglion and spinal cord dorsal horn. Results showed that HPL decreased from day 1 to day 28 after CFA injection, with shortest at day 14. VR1 expression correspondingly increased from day 1 to day 21 with peak at day 14, and returning to the control level at day 28. A shift of VRI expression from small to medium DRG neurons over the observation period was seen. These results suggest that VR1 could play an important role in the early stage, but not the late stage, of CFA inflammatory nociception.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Luo H,Cheng J,Han JS,Wan Ydoi
10.1097/00001756-200403220-00016subject
Has Abstractpub_date
2004-03-22 00:00:00pages
655-8issue
4eissn
0959-4965issn
1473-558Xpii
00001756-200403220-00016journal_volume
15pub_type
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