Abstract:
:Reward-processing neurocircuitry has been delineated using verbal or visual processing and/or decision-making tasks. We examined more basic processes of listening to enjoyable music in healthy and depressed patients. The paradigm was passive, individualized, and brief. Sixteen depressed and 15 control individuals provided favorite music and identified neutral music from selections provided. In the fMRI scanner, individuals heard their neutral and their favorite music for 3 min each. Favorite versus neutral music-listening contrasts showed greater activation in controls than depressed patients in medial orbital frontal cortex and nucleus accumbens/ventral striatum. Left medial prefrontal cortex activity was positively correlated with pleasure scores, whereas middle temporal cortex and globus pallidus were negatively correlated with pleasure. This paradigm activated neurocircuitry of reward processing and showed clinically meaningful alterations in depression.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Osuch EA,Bluhm RL,Williamson PC,Théberge J,Densmore M,Neufeld RWdoi
10.1097/WNR.0b013e32832f4da3subject
Has Abstractpub_date
2009-08-26 00:00:00pages
1204-8issue
13eissn
0959-4965issn
1473-558Xjournal_volume
20pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Human short-latency cortical responses to median nerve stimulation were investigated with a new high resolution electroencephalography technology that markedly enhanced spatial details of somatosensory-evoked potentials (SEPs). Maximum amplitude potentials were estimated over contralateral and/or frontal-mesial scalp ...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199710200-00011
更新日期:1997-10-20 00:00:00
abstract::Prior research with rodent models, performed predominantly in males, has demonstrated a significant association between focal neocortical malformations (e.g. ectopias and microgyria) and rate-specific auditory processing deficits. In the current study and consistent with prior findings, we report that ectopic male BXS...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200212030-00021
更新日期:2002-12-03 00:00:00
abstract::Short-latency ocular following responses in monkeys, induced by first- and second-order motion during a fixation task, were sensitive to stimulus size, retinal eccentricity and motion duration. Latency of eye movements was no different for first- or second-order motion and simply marked the occurrence of movement in t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199812010-00039
更新日期:1998-12-01 00:00:00
abstract::Chronic nicotine exposure enhances axon reflexes in adult rats. Since smoking mothers expose their infants to nicotine, this study investigated whether late gestational and or lactational maternal nicotine exposure affects neonatal axon reflexes. Osmotic pumps, implanted subcutaneously in adult female rats, delivered ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199306000-00008
更新日期:1993-06-01 00:00:00
abstract::The existence of a CRF-dependent inhibition of GnRH transcription was investigated using a neuronal GnRH-expressing cell line (Gn11) stably transfected with mouse (-611 bp) or chicken (-3000 bp) GnRH promoter/luciferase reporter constructs. The presence of the CRF-R1 receptor was established using a specific CRF-R1 an...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199810050-00003
更新日期:1998-10-05 00:00:00
abstract::Transient receptor potential vanilloid 1 (TRPV1) channel has been found to be expressed in a variety of tissues over the last few years, including the central nervous system (CNS). However, the distribution of TRPV1 in the CNS remains a controversial question. Here, we reveal that the expression of TRPV1 can be detect...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000105
更新日期:2014-04-16 00:00:00
abstract::Using quantitative autoradiography, the present study examined ionotropic glutamatergic receptor binding sites using [3H]dizocilpine, [3H]alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate, and [3H]kainate in the posterior cingulate cortex of schizophrenia patients and matched controls. We found a significant increa...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000174056.11403.71
更新日期:2005-08-22 00:00:00
abstract::The role of spinal NMDA receptors in mechanical nociceptive processing was assessed in sheep. Intrathecal NMDA (2 nmol-1 micromol) produced a significant reduction in mechanical withdrawal thresholds. This effect was attenuated by pretreatment with the NMDA receptor antagonist MK801 (100 nmol), the cyclooxygenase-2 (C...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199902250-00002
更新日期:1999-02-25 00:00:00
abstract::To investigate the implications of duration of deafness in the rehabilitation of unilateral deafness utilizing cochlear implantation. From the ongoing prospective cochlear implantation in unilateral deafness study, we looked at five adults who received a cochlear implant for long-term unilateral deafness. Speech perce...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283642a93
更新日期:2013-09-11 00:00:00
abstract::Because salicylate is known to produce tinnitus in humans and animals, the effect of salicylate on the auditory system of gerbils was investigated using [14C]2-deoxyglucose (2-DG). Salicylate treatment reduced activity in the inferior colliculus (IC), particularly in the high frequency part, whereas activation along s...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199607080-00010
更新日期:1996-07-08 00:00:00
abstract::Amyotrophic lateral sclerosis is an incurable disease in which cerebral and spinal motoneurons degenerate, causing paralysis and death within 2-5 years. One of the pathogenic factors of motoneuron death is a chronic excess of glutamate, which exceeds its removal by astrocytes, i.e. excitotoxicity. Extra glutamate upta...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200310270-00017
更新日期:2003-10-27 00:00:00
abstract::Cortical processes underlying perception of musical consonance were investigated by long-latency auditory evoked potentials (EPs). Subjects listened to a random sequence of dyadic pure tones paired at various pitch intervals (1, 4, 6, 7, or 9 semitones). Amplitudes of P2 and N2 components of auditory EPs were signific...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200312190-00003
更新日期:2003-12-19 00:00:00
abstract::Auditory evoked magnetic fields were recorded with a 24-SQUID magnetometer on a patient with a vascular lesion in the right auditory cortex and its vicinity. The contralateral transient 100 ms response (N100m) was absent over the damaged side, with no recovery within 16 months. Responses were normal over the healthy s...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199201000-00025
更新日期:1992-01-01 00:00:00
abstract::Pharmacological manipulation of brain dopamine concentration affects visuospatial working memory in humans and in animals, the latter effects localized to the prefrontal cortex. However, the effects of dopamine agonists on humans are poorly understood. We hypothesized that bromocriptine would have an effect on cogniti...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199711100-00032
更新日期:1997-11-10 00:00:00
abstract::This study was performed to test the hypothesis that diminution in the preovulatory luteinizing hormone (LH) surge in middle-aged (MA) rats may be related to altered activity in nitric oxide (NO)ergic neurons. To begin to test the hypothesis, gene expression of hypothalamic NO synthase (NOS), the enzyme that catalyzes...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199812210-00006
更新日期:1998-12-21 00:00:00
abstract::Using PET, subtraction and correlation analysis were jointly employed to determine the specific and complementary contributions of frontal and medial temporal regions to verbal episodic encoding and retrieval processes. Subtraction analysis highlighted prefrontal rCBF increases which were predominantly left-sided duri...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200106130-00044
更新日期:2001-06-13 00:00:00
abstract::Chronic ethanol (EtOH) exposure can cause intracellular Ca overload by stimulating calcium channel receptors and trigger apoptosis of neurons. NCX3 may play a cytoprotective role in intracellular Ca excretion. In this study, the effect of EtOH on NCX3 was analyzed by observing NCX3 expression in the hippocampus of chr...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001214
更新日期:2019-04-10 00:00:00
abstract::In mammals, the thalamic intergeniculate leaflet (IGL) conveys behavioral (non-photic) phase-resetting information to the circadian clock of the suprachiasmatic nucleus. Here we report a 24 h fluctuation in in vivo serotonin release in the hamster IGL region, peaking at night. Novel wheel exposure at midday, a stimulu...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200401190-00021
更新日期:2004-01-19 00:00:00
abstract::Neurotrophins are promising candidates to slow the progression of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease in which spinal and cortical motoneurons selectively degenerate. In a long-term in vitro model, malonate-induced toxicity and cell death of motoneurons have been demonstrated. Here we stud...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200105250-00013
更新日期:2001-05-25 00:00:00
abstract::We investigated the protective effects of edaravone, a free radical scavenger, against ischemic damage of inner hair cells (IHCs) in gerbils. Cochlear ischemia was induced in the animals by occluding the vertebral arteries bilaterally for 15 min. Edaravone (1 mg/kg, i.v.) or saline was administered 1 h after ischemia....
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200310060-00025
更新日期:2003-10-06 00:00:00
abstract::Automatic phrase-building processes were investigated in second-language (L2) learners of French (native German speakers). Event-related brain potentials were recorded while participants listened to syntactically or semantically correct or incorrect French sentences containing a subject-modifying relative clause. Phra...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f1d518
更新日期:2007-12-03 00:00:00
abstract::In this study, an algorithm is introduced for the automatic detection and simultaneous topographic classification of interictal regional spike activity in pediatric surface EEG records. The algorithm is based on the classification of the topographic distribution of instantaneous power by means of a 'group' trained cla...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199707070-00021
更新日期:1997-07-07 00:00:00
abstract::The most important risk factor for developing Parkinson's disease (PD) is age. Aging is ascribed to different mechanisms, including telomere shortening. Telomeres consist of repetitive DNA sequences and stabilize chromosome integrity. Currently, however, the data reported on telomere shortening in PD patients are inco...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000099
更新日期:2014-03-26 00:00:00
abstract::Stop-consonant discrimination was investigated in normal-hearing listeners and cochlear-implanted patients (CIP) by recording auditory evoked potentials (AEPs) to /b epsilon/ and /p epsilon/ syllables. This study demonstrates that: (i) AEPs show time-locked components that mimic the temporal structure of the stimuli, ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200403220-00006
更新日期:2004-03-22 00:00:00
abstract::SCN1A gene mutations are associated with epilepsy and neurodevelopmental disorders. This study aimed to explore the genotype and phenotype spectrum of SCN1A gene related epilepsy. Epileptic patients who were treated in the Children's Hospital of Chongqing Medical University from January 2015 to July 2018 and identifie...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001259
更新日期:2019-06-12 00:00:00
abstract::The brain-derived neurotrophic factor (BDNF) affects the developing cerebellar granule cells. Exposure of 9-11-day-old primary cultures of rat cerebellar granule neurones for 3 h to a more depolarizing medium (additional 15-30 mM KCl) stimulated the release of glutamate and increased the BDNF mRNAs levels. This BDNF a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1993-09-03 00:00:00
abstract::Production and differentiation of olfactory neurons occur in spherical, multi-neuronal aggregates that form in cultures where dissociated newborn rat nasal cells are plated on to CNS glial cells. We show here that neuronal cell bodies were primarily located in the peripheral layers of the spheres, and almost every neu...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199401000-00003
更新日期:1994-01-31 00:00:00
abstract::We investigated the role of kainate receptor activation in modulating the influx of Ca2+ coupled to the exocytotic release of glutamate in rat hippocampal synaptosomal fractions (P2). In whole hippocampus synaptosomes stimulation with domoic acid increased the intracellular free Ca2+ concentration ([Ca2+]i) in a dose-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199605170-00023
更新日期:1996-05-17 00:00:00
abstract::We conducted semiautomated, atlas-based analyses of regional brain volume changes on MRIs of children and adolescents with Down syndrome (DS) (N=15), DS with comorbid autism spectrum disorder (ASD) (N=15), and age-matched or sex-matched typically developing controls (N=22). Selective volumetric changes were correlated...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282faa8d8
更新日期:2008-04-16 00:00:00
abstract::This study shows distributions of lacZ-positive cells in the vestibular labyrinthine explants of young guinea pigs with mature ears. When adenovirus lacZ vectors were administered to the vestibular labyrinth following removal of the otoconial membrane, lacZ-positive cells were observed in the mesothelial cells in the ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200112210-00032
更新日期:2001-12-21 00:00:00