Brain activation to favorite music in healthy controls and depressed patients.

Abstract:

:Reward-processing neurocircuitry has been delineated using verbal or visual processing and/or decision-making tasks. We examined more basic processes of listening to enjoyable music in healthy and depressed patients. The paradigm was passive, individualized, and brief. Sixteen depressed and 15 control individuals provided favorite music and identified neutral music from selections provided. In the fMRI scanner, individuals heard their neutral and their favorite music for 3 min each. Favorite versus neutral music-listening contrasts showed greater activation in controls than depressed patients in medial orbital frontal cortex and nucleus accumbens/ventral striatum. Left medial prefrontal cortex activity was positively correlated with pleasure scores, whereas middle temporal cortex and globus pallidus were negatively correlated with pleasure. This paradigm activated neurocircuitry of reward processing and showed clinically meaningful alterations in depression.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Osuch EA,Bluhm RL,Williamson PC,Théberge J,Densmore M,Neufeld RW

doi

10.1097/WNR.0b013e32832f4da3

subject

Has Abstract

pub_date

2009-08-26 00:00:00

pages

1204-8

issue

13

eissn

0959-4965

issn

1473-558X

journal_volume

20

pub_type

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