Abstract:
:We conducted semiautomated, atlas-based analyses of regional brain volume changes on MRIs of children and adolescents with Down syndrome (DS) (N=15), DS with comorbid autism spectrum disorder (ASD) (N=15), and age-matched or sex-matched typically developing controls (N=22). Selective volumetric changes were correlated with neurobehavioral measures to determine their functional significance. DS involved selective reduction of frontal and parietal gray matter volumes, beyond the global microencephaly typically observed in this condition. DS with comorbid ASD involved relative hyperplasia of white matter in the cerebellum and brainstem compared with DS only. Cerebellar white matter volumes were positively correlated with severity of stereotypies, a distinctive feature of ASD in DS.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Carter JC,Capone GT,Kaufmann WEdoi
10.1097/WNR.0b013e3282faa8d8subject
Has Abstractpub_date
2008-04-16 00:00:00pages
653-6issue
6eissn
0959-4965issn
1473-558Xpii
00001756-200804160-00010journal_volume
19pub_type
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