Serum homocysteine, folate level and methylenetetrahydrofolate reductase 677, 1298 gene polymorphism in Korean schizophrenic patients.

Abstract:

:High homocysteine serum level has been regarded as one of the important factors that influence the development of schizophrenia. Genetic variations of methylenetetrahydrofolate reductase, which is a main enzyme reducing homocysteine level, are reported in schizophrenic patients. We measured the serum level of homocysteine/folate and methylenetetrahydrofolate reductase C677T/A1298C gene polymorphism in 235 patients with schizophrenia. Plasma homocysteine levels were higher and folate levels were lower in patients than in comparison subjects. Variations of C677T were more frequent in patients than in comparison subjects. Patients with the 677TT genotype showed higher homocysteine levels than patients with the CC and CT genotypes. These findings suggest that folate supplement may be beneficial to some schizophrenic patients with homocysteinemia due to the genetic defect of methylenetetrahydrofolate reductase.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Lee YS,Han DH,Jeon CM,Lyoo IK,Na C,Chae SL,Cho SC

doi

10.1097/01.wnr.0000215777.99473.52

subject

Has Abstract

pub_date

2006-05-15 00:00:00

pages

743-6

issue

7

eissn

0959-4965

issn

1473-558X

pii

00001756-200605150-00011

journal_volume

17

pub_type

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