Abstract:
:High homocysteine serum level has been regarded as one of the important factors that influence the development of schizophrenia. Genetic variations of methylenetetrahydrofolate reductase, which is a main enzyme reducing homocysteine level, are reported in schizophrenic patients. We measured the serum level of homocysteine/folate and methylenetetrahydrofolate reductase C677T/A1298C gene polymorphism in 235 patients with schizophrenia. Plasma homocysteine levels were higher and folate levels were lower in patients than in comparison subjects. Variations of C677T were more frequent in patients than in comparison subjects. Patients with the 677TT genotype showed higher homocysteine levels than patients with the CC and CT genotypes. These findings suggest that folate supplement may be beneficial to some schizophrenic patients with homocysteinemia due to the genetic defect of methylenetetrahydrofolate reductase.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Lee YS,Han DH,Jeon CM,Lyoo IK,Na C,Chae SL,Cho SCdoi
10.1097/01.wnr.0000215777.99473.52subject
Has Abstractpub_date
2006-05-15 00:00:00pages
743-6issue
7eissn
0959-4965issn
1473-558Xpii
00001756-200605150-00011journal_volume
17pub_type
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