Abstract:
:Timing of the mammalian circadian clock of the suprachiasmatic nucleus (SCN) is regulated by photic input from the retina. Retinorecipient units entrain rhythmicity of SCN pacemaker cells in part through their release of vasoactive intestinal polypeptide (VIP). The underlying nature of this process is conjectural, however, as in-vivo SCN VIP release has never been measured. Here, SCN microdialysis was used to investigate mechanisms regulating VIP. Hamsters under light-dark cycle of 14:10 exhibited a daily peak in synaptic VIP release near midday. Under constant darkness, this output was arrhythmic. Light and the glutamatergic agonist, N-methyl-D-aspartate, stimulated VIP release at night, whereas the serotonin (1A,7) agonist, (±)8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide, suppressed release at midday. Hence, SCN VIP activity is stimulated by photic input and inhibited by serotonin.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Francl JM,Kaur G,Glass JDdoi
10.1097/WNR.0b013e32833fcba4subject
Has Abstractpub_date
2010-11-17 00:00:00pages
1055-9issue
16eissn
0959-4965issn
1473-558Xjournal_volume
21pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Diffusion tensor imaging was used to measure regional differences in brain white matter microstructure (intravoxel coherence) and macrostructure (intervoxel coherence) and age-related differences between men and women. Neuropsychiatrically healthy men and women, spanning the adult age range, showed the same pattern of...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200101220-00027
更新日期:2001-01-22 00:00:00
abstract::Retinal gamma-aminobutyric acid type C (GABA[C]) receptors are believed to consist of rho subunits. The pharmacological properties of GABA(C) receptors appear to vary among different species. Since the mouse is an important model for gene targeting and behavioral studies, this study was aimed at cloning rho subunits i...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199801260-00010
更新日期:1998-01-26 00:00:00
abstract::Experiments using chimeric stimuli have shown that the right hemisphere is more influential in processing facial information. Here, again, we found clear evidence that study participants used the information from the left side of the face to inform their gender decisions when chimeric male/female, female/male stimuli ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200512190-00004
更新日期:2005-12-19 00:00:00
abstract::This study examined the basis for introducing an ignoring task during cortical evoked response audiometry (CERA) using the N1-P2 response. Healthy hearing participants were assigned to two groups with and without an ignoring task (ignoring and listening groups) during CERA whose outcomes were compared with the pure-to...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833b502a
更新日期:2010-07-14 00:00:00
abstract::Elevations of cytosolic free Ca2+ concentration ([Ca2+]i) induced by addition of ATP have been compared in rat dorsal horn neurones in slices and after their isolation. ATP application induced in neurones in situ a rise of [Ca2+]i by 201 +/- 12 nM. In Ca2+-free external solution the rise was 156 +/- 14 nM (n = 45 of 7...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200111160-00026
更新日期:2001-11-16 00:00:00
abstract::It has been previously demonstrated that members of the neurotrophin family may prevent death of motoneurones following axotomy. Here we report that the expression of mRNA for full-length trkB, which is a signal transducing receptor for BDNF and NT-4, increases transiently in spinal motoneurones after axotomy in adult...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199402000-00009
更新日期:1994-02-24 00:00:00
abstract::Disturbances in methyl-carbon metabolism, which result in hyperhomocysteinemia, have been associated with schizophrenia. Homozygosity for the T677 allele of the methylenetetrahydrofolate reductase (MTHFR) gene, which encodes for a thermolabile enzyme associated with hyperhomocysteinemia, has been found to be increased...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199907130-00008
更新日期:1999-07-13 00:00:00
abstract::Nerve damage often leads to nervous system dysfunction and neuropathic pain. The serine-threonine kinases receptor-interacting protein 1 (RIP1) and 3 (RIP3) are associated with inflammation and cell necrosis. This study aimed to explore the role of RIP1 and RIP3 in sciatic nerve chronic constriction injury (CCI) in mi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001120
更新日期:2018-11-07 00:00:00
abstract::Maintenance of long-term potentiation in perforant path-granule cell synapses is accompanied by increased glutamate release. Here we investigate the role of synaptophysin in release and in expression of long-term potentiation in dentate gyrus. We report that long-term potentiation was accompanied by increased endogeno...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199808030-00012
更新日期:1998-08-03 00:00:00
abstract::The functions of the fields of the mammalian auditory cortex in sound perception and recognition are unknown. We used Fos (a protein of the inducible immediate-early gene c-fos) as a cellular marker of activated brain areas to show in the mouse (Mus domesticus) that sound is processed differentially in auditory cortic...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199908020-00022
更新日期:1999-08-02 00:00:00
abstract::PEC-60, a 60-residue intestinal peptide structurally related to the pancreatic secretory type of trypsin inhibitor, has been isolated, characterized and molecularly cloned. It shows biological activity as a hormone in both the gastrointestinal tract and in the immune system. We now report immunohistochemical evidence ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199409080-00033
更新日期:1994-09-08 00:00:00
abstract::Dopaminergic neurotransmission is thought to be involved in reward-related incentive learning and addictive behaviour. Amphetamine will alter glycogen synthase kinase-3β (GSK-3β) activity by increasing dopamine transporter efflux rates. We investigated the hypothesis that Wnt signalling will be altered in rat nucleus ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328357d868
更新日期:2012-10-03 00:00:00
abstract::Brief tetanic stimulation of parallel fibres can evoke a slow excitatory postsynaptic potential (EPSP) in cerebellar Purkinje cells that is mediated by metabotropic glutamate receptors (mGluRs). It is likely that the receptor subtype involved is mGluR1, which couples to the production of diacylglycerol and inositol-1,...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199608120-00017
更新日期:1996-08-12 00:00:00
abstract::A tritiated specific and highly potent 5-HT4 antagonist: [3H]-GR113808 was used to label specific binding sites in human brain and for comparison in guinea-pig brain. [3H]-GR113808 association and dissociation were rapid, the binding was saturable and displaced by various serotoninergic agents with an affinity corresp...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199309000-00007
更新日期:1993-09-10 00:00:00
abstract::Nitric oxide (NO), a free radical gas that acts as a neural messenger, is produced from L-arginine by the enzyme nitric oxide synthase (NOS). The present study describes the autoradiographic localization throughout rat brain of the binding of [3H]L-NG-nitro-arginine ([3H]L-NOARG), a reversible NOS inhibitor, and confi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199510020-00005
更新日期:1995-10-02 00:00:00
abstract::It has been widely shown that recognition memory includes two distinct retrieval processes: familiarity and recollection. Many studies have shown that recognition memory can be facilitated when there is a perceptual match between the studied and the tested items. Most event-related potential studies have explored the ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000652
更新日期:2016-09-28 00:00:00
abstract::Axonal atrophy may reflect earlier and more reversible events in neurodegeneration and ageing than somatic atrophy. Innervation density by sympathetic fibres from the rat superior cervical ganglion (SCG) to the middle cerebral artery (MCA) decreases dramatically in old age, while that to the iris is largely unchanged....
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199702100-00044
更新日期:1997-02-10 00:00:00
abstract:OBJECTIVE:Cervical spondylotic myelopathy is regarded as a chronic, special incomplete spinal cord injury, so the sensory components transmitted to thalamus decreased after distal spinal cord injury, which lead the disturbance of thalamus-cortex circuits, which might explain the alterations of clinical function of cerv...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001346
更新日期:2020-03-25 00:00:00
abstract::Results from a computer model of a thalamic network predict that agents augmenting GABA(A)-mediated inhibition in the reticular thalamic (RE) nucleus will be antiepileptic or desynchronizing. This provides support for the hypothesis that antiepileptics like benzodiazepines may exert their effects through an isolated i...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199803090-00024
更新日期:1998-03-09 00:00:00
abstract::Stop-consonant discrimination was investigated in normal-hearing listeners and cochlear-implanted patients (CIP) by recording auditory evoked potentials (AEPs) to /b epsilon/ and /p epsilon/ syllables. This study demonstrates that: (i) AEPs show time-locked components that mimic the temporal structure of the stimuli, ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200403220-00006
更新日期:2004-03-22 00:00:00
abstract::The distribution of c-fos proto-oncogene expression has been studied in the periaqueductal grey matter (PAG) of non-intentional-stimulated rats by immunohistochemistry. A mean number of 53 +/- 9 Fos-like immunoreactive cells per hemiPAG, distributed into three groups, dorsolateral, lateral and ventrolateral, was found...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199611040-00068
更新日期:1996-11-04 00:00:00
abstract::In the present study we tested the hypothesis that baclofen, a GABA-B receptor agonist, attenuates methamphetamine self-administration. Fifteen rats were trained to self-administer i.v. injections of methamphetamine (0, 0.0625, 0.125 and 0.25 mg/kg/injection) on a progressive ratio schedule of reinforcement, and then ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200207020-00007
更新日期:2002-07-02 00:00:00
abstract::The aim of this study was to investigate whether the DNA methylation pattern within the alpha synuclein promoter region is altered in intoxicated and early abstinence patients with alcoholism undergoing alcohol withdrawal. We observed a significant increase of the alpha synuclein promoter DNA methylation in patients w...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200502080-00020
更新日期:2005-02-08 00:00:00
abstract::We have used double quantum filtered (DQF) 23Na+ nuclear magnetic resonance (NMR) spectroscopy without shift reagents in order to monitor intracellular Na+ (Na+i) in a cortical brain slice preparation. The external Na+ (Na+o) signal was reduced by 95% by the DQF sequence compared with the directly observed 23Na+. The ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199302000-00006
更新日期:1993-02-01 00:00:00
abstract::We show that the pro-apoptotic proteins Bax and Bak trigger apoptosis when over-expressed in sympathetic neurons cultured in the presence of NGF. This effect can be blocked with z-VAD-fmk, a peptide inhibitor of caspases, but not with anti-apoptotic chemical compounds such as antioxidants or proteasome inhibitors. The...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199801050-00004
更新日期:1998-01-05 00:00:00
abstract::The aim of this study was to reveal a potential effect of emotion on cognitive control in the implicit memory task with emotionally neutral and unpleasant words in healthy controls and patients with schizophrenia using a 3.0 T functional MRI (fMRI). A total of 15 patients with schizophrenia and 15 healthy controls und...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000405
更新日期:2015-08-05 00:00:00
abstract::Functional MRI (fMRI) can detect changes from resting levels of blood flow and oxygenation during task performance (i.e. activation). We used a simple electrical nerve stimulation technique together with fMRI to study pain process in the human cortex. Images of the primary somatosensory (SI) and cingulate cortex (Cg) ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1995-12-29 00:00:00
abstract::The precise role of prostaglandin-D-synthase (beta-trace protein), the major constituent of cerebrospinal fluid, is unclear. In the present study, a sensitive and highly specific fluoroimmunoassay was developed. The measurement of the enzyme levels in rat CSF revealed a developmental change in the CSF levels with the ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199803300-00028
更新日期:1998-03-30 00:00:00
abstract::It has recently been proposed that brain responses in the gamma-range (> 20 Hz) include information about specific cognitive processes in the human brain. Empirical data substantiating this assumption come from EEG and MEG recordings during visual and language processing. For example, 30 Hz activity has been found to ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199510010-00025
更新日期:1995-10-23 00:00:00
abstract::Numerous studies have shown that the cerebellum is involved in classical conditioning of specific aversive reactions. Only few studies, however, have examined the exact localization of cerebellar areas involved in the control of unconditioned reflex responses. The present study investigated cerebellar areas, which are...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200212030-00031
更新日期:2002-12-03 00:00:00