Abstract:
:Nitric oxide (NO), a free radical gas that acts as a neural messenger, is produced from L-arginine by the enzyme nitric oxide synthase (NOS). The present study describes the autoradiographic localization throughout rat brain of the binding of [3H]L-NG-nitro-arginine ([3H]L-NOARG), a reversible NOS inhibitor, and confirms the heterogeneous distribution of the NOS enzyme. [3H]L-NOARG binding was enriched in discrete neuronal populations and the distribution observed was identical to that previously described for NOS using immunohistochemistry, in situ hybridization and NADPH-diaphorase staining. [3H]L-NOARG autoradiography should be a useful method for the further characterization and quantification of NOS in brain and other tissues.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Burazin TC,Gundlach ALdoi
10.1097/00001756-199510020-00005subject
Has Abstractpub_date
1995-10-02 00:00:00pages
1842-4issue
14eissn
0959-4965issn
1473-558Xjournal_volume
6pub_type
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