Abstract:
:Brief tetanic stimulation of parallel fibres can evoke a slow excitatory postsynaptic potential (EPSP) in cerebellar Purkinje cells that is mediated by metabotropic glutamate receptors (mGluRs). It is likely that the receptor subtype involved is mGluR1, which couples to the production of diacylglycerol and inositol-1,4,5-trisphosphate (IP3). We therefore examined whether the mGluR-EPSP is associated with an increase in cytosolic free calcium [Ca2+]i using simultaneous Ca2+ imaging and electrophysiological recordings. An mGluR-EPSP could be evoked in all nine Purkinje cells tested. In all but one this potential was not associated with measurable changes in [Ca2+]i whereas single calcium spikes produced large Ca2+ transients. In the one Purkinje cell where [Ca2+]i was elevated, the rise was estimated to be roughly 20-fold smaller than that produced by a single Ca2+ spike.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Batchelor AM,Vranesic I,Del Principe F,Garthwaite J,Knöpfel Tdoi
10.1097/00001756-199608120-00017subject
Has Abstractpub_date
1996-08-12 00:00:00pages
1949-52issue
12eissn
0959-4965issn
1473-558Xjournal_volume
7pub_type
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