Abstract:
:A double-stranded DNA end-binding factor with high levels of expression in brain and testis of adult mice was identified as the Ku protein, earlier described as an autoantigen in connective tissue diseases and found to be essential for recombination of the immunoglobulin genes and DNA repair. High Ku levels were found in the cerebellum and pituitary gland, lower levels in the hippocampus, hypothalamus and white matter structures. Ku levels were much higher in embryonic rat brain than in the adult brain, suggesting a role of the Ku protein in brain development. In embryonic rat brain, Ku was associated with cell nuclei, but was predominantly located in the cytosol in the adult rat cerebellum and hippocampus. The abundant expression of Ku in the brain suggests the involvement of Ku autoantibodies in the pathogenesis of neuropsychiatric complications in connective tissue diseases.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Bakalkin G,Yakovleva T,Hurd YL,Nussenzweig A,Li GC,Terenius Ldoi
10.1097/00001756-199806220-00044subject
Has Abstractpub_date
1998-06-22 00:00:00pages
2147-51issue
9eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::The purpose of this study was to examine motor imagery ability in patients with peripheral nerve disorder using the hand mental rotation task. Five patients with left total avulsion brachial plexus palsy (BPP) and 16 healthy age-matched adults participated in this study. The mean±SD time from the injury was 103.6±49.7...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001229
更新日期:2019-04-10 00:00:00
abstract::Because of anecdotal reports in which ibogaine eliminates opioid withdrawal symptoms in humans, we studied this phenomenon in the rat model. Ibogaine (5, 10, 20 and 40 mg kg-1, s.c.) was administered 15 min before naloxone (0.5 mg kg-1, s.c.) in morphine dependent rats (3 days after the s.c. implantation of a 75 mg mo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199009000-00005
更新日期:1990-09-01 00:00:00
abstract::Two monkeys were trained to perform wrist movements to align a pointer with visual targets. In the spatially 'compatible' condition, monkeys had to point at the target position (left/right), whereas in the 'incompatible' condition, they had to point at the position opposite to the target. A large proportion of neurone...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199412000-00014
更新日期:1994-12-20 00:00:00
abstract::Previous research has suggested that exposure to radiofrequency electromagnetic fields increases electroencephalogram spectral power in non-rapid eye movement sleep. Other sleep parameters have also been affected following exposure. We examined whether aspects of sleep architecture show sensitivity to electromagnetic ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000186593.79705.3c
更新日期:2005-11-28 00:00:00
abstract::In the current study we explored the relationship between neurometabolites measured by proton magnetic resonance spectroscopy (1H-MRS) and cognitive ability assessed with a battery of neuropsychological tests. Forty-five participants were recruited from the local college community, and examined utilizing neuropsycholo...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199911080-00014
更新日期:1999-11-08 00:00:00
abstract::Episodic memory for simple commands is better following enacted than verbal encoding. This has been proposed to be due to the possibility to base retrieval on motor information. Here we used PET to test the hypothesis that motor brain areas show increased retrieval-related activity following enacted compared to verbal...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200007140-00027
更新日期:2000-07-14 00:00:00
abstract:OBJECTIVES:There are subclinical neurologic deficits in cirrhotic patients without overt hepatic encephalopathy. We aimed to use F-fluorodeoxyglucose PET/computed tomography to explore the impaired brain glucose metabolism of subclinical hepatic encephalopathy in cirrhosis. METHODS:Thirty-seven patients with hepatitis...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001284
更新日期:2019-08-07 00:00:00
abstract::Electroencephalography (EEG) and gaze data have traditionally been separated in neurocognitive studies because of the artefacts that even small controlled eye movements produce. Study of gaze control in a visual tracking task provides information about an individual's prospective control. By including gaze events in t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000020
更新日期:2013-12-04 00:00:00
abstract::Brief tetanic stimulation of parallel fibres can evoke a slow excitatory postsynaptic potential (EPSP) in cerebellar Purkinje cells that is mediated by metabotropic glutamate receptors (mGluRs). It is likely that the receptor subtype involved is mGluR1, which couples to the production of diacylglycerol and inositol-1,...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199608120-00017
更新日期:1996-08-12 00:00:00
abstract::The amount of backward walking induced in mice by co-administration of clenbuterol, a beta-adrenoceptor agonist and putative antidepressant, and the benzodiazepine chlordiazepoxide was plotted as a three-dimensional surface, using modified Uniras software. The surface was compared with the theoretical surface to be ex...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199207000-00021
更新日期:1992-07-01 00:00:00
abstract::It is known that interleukin-1beta facilitates pain, but the mechanisms of this are not understood. This study investigated the role of interleukin-1beta in the expression of Fos, a marker of neuronal activation, and hyperalgesia caused by injecting complete Freund's adjuvant into one hind paw of the rat. Interleukin-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3280586839
更新日期:2007-03-26 00:00:00
abstract::Brain trauma induces a multitude of reactions at molecular, cellular, and tissue levels, some of which are beneficial to recovery, whereas others are detrimental. Osteopontin (OPN), a glycosylated phosphoprotein, can be found in both the soluble form and as an extracellular matrix constituent in several tissues in the...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328355380e
更新日期:2012-08-01 00:00:00
abstract::We have isolated a cDNA encoding an inwardly rectifying K+ channel (HH-IRK1) from human heart. The cDNA codes for a 427-amino acid protein, with two putative transmembrane domains and an H5 region. The primary structure of HH-IRK1 is homologous to that of the IRK1 channel cloned from a mouse macrophage-like cell line....
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199412000-00024
更新日期:1994-12-20 00:00:00
abstract::Complex tones such as vowels expressed by the human voice vary both in fundamental pitch (harmonic periodicity) and spectrum shape (vowel type). Three different pitches and spectra were combined into nine auditory stimuli. Latencies of cerebral evoked potential components decreased significantly as pitch increased, wh...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199603220-00014
更新日期:1996-03-22 00:00:00
abstract::Altered glutamate signaling is associated with Parkinson's disease. To study the involvement of the cystine/glutamate antiporter in the pathogenesis of Parkinson's disease, we developed new polyclonal antibodies recognizing xCT, the specific subunit of this antiporter. The striatal xCT protein expression level was inv...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328312181c
更新日期:2008-10-29 00:00:00
abstract::The aim of the present study was to determine if both inactivating and non-inactivating potassium currents occur in skeletal muscle cells at early times in culture. Whole cell current was recorded from embryonic muscle cells within 4-10 h of plating. We found that in the cells which had an outward current, half had a ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199204000-00007
更新日期:1992-04-01 00:00:00
abstract::Previous studies in adult rats have demonstrated that the neurotrophin, brain-derived neurotrophic factor (BDNF), is present in virtually all cells of the pituitary intermediate lobe. In the present study, we demonstrate that cells cultured from adult intermediate lobe pituitary (ILP) rapidly lose their BDNF immunorea...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199703240-00005
更新日期:1997-03-24 00:00:00
abstract::(-)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenolic extract in green tea and it has attracted increasing attention for its multiple bioactive effects. However, the mechanisms by which EGCG exerts its neuroprotective actions in Alzheimer's disease (AD) are presently lacking. In the present study, a ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000803
更新日期:2017-07-05 00:00:00
abstract::In rapid serial visual presentation of pictures, an early event-related brain potential component shows enlarged negativity over occipital regions for emotional pictures compared with neutral pictures. The present study examined whether the processing of emotional target pictures varies as a function of stimulus repet...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000203355.88061.c6
更新日期:2006-03-20 00:00:00
abstract::The neuroprotective effects of netrin-1 after spinal cord injury and its specific molecular mechanisms have not been elucidated. In our study, Western blot, transferase UTP nick end labeling staining and immunofluorescence staining first showed that netrin-1 significantly decreased the expression levels of caspase-3, ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001441
更新日期:2020-05-07 00:00:00
abstract::The neurotransmitter acetylcholine is synthesized by choline acetyltransferase (ChAT) and transported into synaptic vesicles by the vesicular acetylcholine transporter (VAChT). Recently it has been reported that the entire coding region of VAChT mRNA is located in the first intron of the ChAT gene. In this study, ChAT...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199505090-00004
更新日期:1995-05-09 00:00:00
abstract::Although decision-making is typically seen as a rational process, emotions play a role in tasks that include unfairness. Recently, activation in the right dorsolateral prefrontal cortex during offers experienced as unfair in the Ultimatum Game was suggested to subserve goal maintenance in this task. This is restricted...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000183907.08149.14
更新日期:2005-11-07 00:00:00
abstract::Aminoglycoside ototoxicity is a well-documented process via several pathophysiological pathways. The protective role of cochlear dopamine, released from the lateral olivocochlear efferents, was implicated previously in case of ischemia or acoustic trauma, as it postsynaptically inhibits the effect of excessively relea...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200110290-00036
更新日期:2001-10-29 00:00:00
abstract::Temporal changes of serotonin (5-HT) content in the median (MRN) and dorsal (DRN) raphe nuclei were measured in rats kept under various lighting conditions. Serotonin content in the MRN and DRN under light-dark (LD) condition showed diurnal rhythmicity, with a peak during early light phase and a trough during the dark...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199310000-00012
更新日期:1993-10-25 00:00:00
abstract::Prior research with rodent models, performed predominantly in males, has demonstrated a significant association between focal neocortical malformations (e.g. ectopias and microgyria) and rate-specific auditory processing deficits. In the current study and consistent with prior findings, we report that ectopic male BXS...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200212030-00021
更新日期:2002-12-03 00:00:00
abstract::We recently reported behavioral improvements following intrastriatal transplantation of cryopreserved cultured human neuroteratocarcinoma-derived cells (hNT neurons) in rats with cerebral ischemia induced by occlusion of the middle cerebral artery. In the present study, the viability and survival of hNT neurons were e...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199808240-00028
更新日期:1998-08-24 00:00:00
abstract::Nerve growth factor (NGF) promotes the survival of several neuronal populations, but recently it has also been shown to induce neuronal cell death. Here we report the effects of NGF on lesioned motoneurons. We have analyzed facial and sciatic motoneurons in newborn and adult BALB/c and C57BL/6 mice, in addition to mic...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:2000-05-15 00:00:00
abstract::Compartmental models of thalamic reticular (RE) neurons were investigated based on current-clamp and voltage-clamp data. Spontaneous oscillations in the model arise from the interaction between inhibitory synaptic currents and the rebound burst of RE cells. These oscillations critically depend on the level of the rest...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199411000-00003
更新日期:1994-11-21 00:00:00
abstract::The present study examined the sleep-wake cycle effects of microinjections of yohimbine, an adrenergic antagonist, and atropine, a cholinergic antagonist, into the cerebral ventricle of clomipramine-induced depressed rats. Yohimbine microinjection caused a significant reduction in the total duration and the number of ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200209160-00006
更新日期:2002-09-16 00:00:00
abstract::The first step in olfactory transduction is the recognition of odor molecules by membrane bound receptors belonging to the superfamily of G-protein coupled receptors; other members of this family are involved in neurotransmission. Based on the considerable homology between individual members of this family, we have in...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199208000-00001
更新日期:1992-08-01 00:00:00