Abstract:
:Brain trauma induces a multitude of reactions at molecular, cellular, and tissue levels, some of which are beneficial to recovery, whereas others are detrimental. Osteopontin (OPN), a glycosylated phosphoprotein, can be found in both the soluble form and as an extracellular matrix constituent in several tissues in the vertebrate body, but its function after brain injury is largely unknown. In this study, the expression of OPN after an experimental traumatic brain injury in rats was examined and its effects on hippocampal neurons and cortical astrocytes were studied using cell-culture techniques. OPN had no influence astrocyte behavior in a scratch assay. However, hippocampal neurons grew well on an OPN substrate with growth comparable to that seen on laminin, but showed a higher degree of primary neurites. Finally, growth on OPN was mediated through β1 intregrins and CD44. These findings indicate that injury-induced OPN may support neurite sprouting, suggesting a role for this molecule in recovery from central nervous system trauma.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Plantman Sdoi
10.1097/WNR.0b013e328355380esubject
Has Abstractpub_date
2012-08-01 00:00:00pages
647-52issue
11eissn
0959-4965issn
1473-558Xjournal_volume
23pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::We used whole-cell recording to identify, for the first time, GABAergic tonic current in subpopulations of substantia gelatinosa neurons in mouse spinal cord slices. Application of the gamma-aminobutyric acid type A receptor antagonist bicuculline revealed tonic currents in 49 of 73 substantia gelatinosa neurons. Thes...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000230515.86090.bc
更新日期:2006-08-21 00:00:00
abstract::In this study it was shown that in adults, the frequency characteristics of EEG preceding stimuli that were followed by incorrect responses were different from the characteristics of EEG preceding stimuli that were followed by correct responses. In the recording during three different tasks that explore different neur...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200008210-00012
更新日期:2000-08-21 00:00:00
abstract::We have isolated a cDNA encoding an inwardly rectifying K+ channel (HH-IRK1) from human heart. The cDNA codes for a 427-amino acid protein, with two putative transmembrane domains and an H5 region. The primary structure of HH-IRK1 is homologous to that of the IRK1 channel cloned from a mouse macrophage-like cell line....
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199412000-00024
更新日期:1994-12-20 00:00:00
abstract::The expression pattern of metabotropic glutamate receptor 1alpha (mGluR1alpha) was immunohistochemically investigated in substantia nigra dopaminergic neurons of the macaque monkey. In normal monkeys, mGluR1alpha immunoreactivity was weakly observed in the dorsal tier of the substantia nigra pars compacta (SNc-d) wher...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000074344.81633.e4
更新日期:2003-05-23 00:00:00
abstract::The present paper reports how aluminium [Al(III)] at a concentration of 3.7 microM can activate the bovine erythrocytic enzyme acetylcholinesterase (AChE) by about 38% in vitro. This same activating effect was observed on AChE form human as well as from rat erythrocyte ghosts and murine neuroblastoma cells. The intera...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199409080-00023
更新日期:1994-09-08 00:00:00
abstract::A novel allograft paradigm was used to test whether adult mammalian central axons regenerate within a peripheral nerve environment containing intact sensory axons. Retinal ganglion cell axon regeneration was compared following anastomosis of dorsal root ganglia grafts or conventional peripheral nerve grafts to the adu...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000195668.07467.a8
更新日期:2006-02-06 00:00:00
abstract::We can report, that by the use of indirect immunofluorescence techniques, that rat spinal motoneurons contain galanin-like immunoreactivity (LI). Furthermore, that galanin and calcitonin gene-related peptide (CGRP)-LI coexist in a number of spinal motoneurons. Co-localization could be demonstrated as thoracic, lumbar ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199204000-00003
更新日期:1992-04-01 00:00:00
abstract::Numerous reports have shown that cyclin-dependent kinase 5 (Cdk5), a proline-directed serine/threonine kinase, critically contributes to the induction and maintenance of chronic pain induced by peripheral inflammation and nerve injury. Recent evidence has also suggested the critical role of an epigenetic mechanism in ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000237
更新日期:2014-10-01 00:00:00
abstract::Immunohistochemical techniques were employed to examine the distribution of RNA-binding proteins A2 and B1 in the rat forebrain. Intense A2 and B1 immunolabeling were observed in the nucleoplasm of the neurons in the cerebral cortices, hippocampal formation, olfactory regions, caudate-putamen as well as the supraoptic...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200009280-00012
更新日期:2000-09-28 00:00:00
abstract::We investigated the effects of radio frequency electromagnetic fields on brain physiology. Twenty-four healthy young men were exposed for 30 min to pulse-modulated or continuous-wave radio frequency electromagnetic fields (900 MHz; peak specific absorption rate 1 W/kg), or sham exposed. During exposure, participants p...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/WNR.0b013e3280d9435e
更新日期:2007-05-28 00:00:00
abstract::Neural cells have distinct responses to CNS injury; however, neural progenitor response to CNS injury is not yet documented. Stab injury combined with injection of bromodeoxyuridine (BrdU), a thymidine analog, into adult rat cortex above the lateral ventricle for 10 min resulted in activated microglia/macrophage infil...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199908020-00012
更新日期:1999-08-02 00:00:00
abstract::Using subtractive cloning, we identified a 1.4 kb mRNA that was ubiquitously expressed in various tissues; this mRNA was highly up-regulated in amygdala nuclei in mice when morphine was repeatedly administered but not when an opiate-receptor antagonist was co-administered. The mRNA encodes a 23 kDa protein, designated...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200211150-00018
更新日期:2002-11-15 00:00:00
abstract::Human morning/evening preferences has recently been reported to be associated with polymorphism of the 3' flanking region of the Clock gene, which was the first identified mammalian circadian clock gene. We recorded body temperature, spontaneous activity, electroencephalogram and electromyogram for 48 h in mice with J...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200105250-00033
更新日期:2001-05-25 00:00:00
abstract::Administration of either a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801 (dizocilpine), or a muscarinic antagonist, scopolamine, produces dose-related impairments in performance of a visual recognition memory task, delayed non-matching to sample (DNMS) with lists of 20 symbols, in rhesus monk...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199601310-00045
更新日期:1996-01-31 00:00:00
abstract::As manifestations of prion diseases include disturbances of hypothalamic and pituitary functions, we tested the hypothesis that the cellular prion protein (PrPC) has a role as modulator of the hypothalamic-pituitary-adrenal axis. The level of corticosterone and adrenocorticotropic hormone were compared in PrPC null (P...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32830f1e90
更新日期:2008-10-08 00:00:00
abstract::In Xenopus oocytes coinjected with poly(A)+ RNA derived from the rat cerebellum and cRNAs for the cloned G protein-gated inwardly rectifying K+ channel (GIRK), GIRK1 and GIRK2, the GABA-B agonist baclofen elicited inwardly rectifying K+ currents. The inward K+ currents elicited by baclofen were inhibited by the select...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199803090-00004
更新日期:1998-03-09 00:00:00
abstract::The pathogenesis of amyotrophic lateral sclerosis remains poorly understood, but microglial and astroglial activation are thought to contribute to motor neuron death. Evidence suggests that matrix metalloproteinase-9 (MMP-9) is a mediator of this deleterious effect. In this study, we evaluated the effect of MMP-9 on t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200503150-00003
更新日期:2005-03-15 00:00:00
abstract::The present study investigated the effect of lexical competition on the time course of spoken word recognition in Mandarin Chinese using a unimodal auditory priming paradigm. Two kinds of competitive environments were designed. In one session (session 1), only the unrelated and the identical primes were presented befo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000492
更新日期:2016-01-20 00:00:00
abstract::Previous studies have indicated that estrogen protects the brain from ischemic damage and regulates K(ATP) channel activity; the present study was designed to address the involvement of K(ATP) channels in the neuroprotective effects of estrogen in focal cerebral ischemia: in experiment 1, K(ATP) mRNA and protein in th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283598de6
更新日期:2012-11-14 00:00:00
abstract::Human scalp EEG has demonstrated that global coherence among distant areas increases during cognitive tasks, suggesting that oscillating neural activities work to generate global neuronal assemblies for cognitive functions. The theta oscillation in a frequency range of 4-8 Hz with large amplitudes which emerges during...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000126755.09715.b3
更新日期:2004-06-07 00:00:00
abstract::In the present study, we tested the hypothesis that interleukin (IL)-10 down-regulates human microglial cell IL-8 release by inhibiting activation of nuclear factor kappa B (NF-kappaB). Immunohistochemical staining demonstrated that IL-10 markedly suppressed lipopolysaccharide (LPS)- and IL-1beta-stimulated IL-8 expre...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199806010-00010
更新日期:1998-06-01 00:00:00
abstract::Self-renewing neural stem cells and progenitor cells are cell populations that generate radial glial cells and neurons through asymmetric division. Regulation of intracellular pH in stem cells with high metabolic activity is critical for both cell signaling and proliferation. We have recently found that a S0859-inhibi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001372
更新日期:2020-01-08 00:00:00
abstract::In situ hybridization was used to localize mRNA encoding two cooperative serine/threonine kinase receptors. Activin receptor IIA mRNA in the adult rat brain is highly expressed in the dentate gyrus, in the pyramidal neurones of CA3 and CA1, in the entorhinal cortex, in the cortical amygdaloid nucleus and in the amygda...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1995-12-29 00:00:00
abstract::Two groups of hemiparkinsonian rats received grafts of embryonic ventral mesencephalon with or without the addition of the NMDA receptor antagonist (+)dizocilpine hydrogen maleate (MK-801). When added to the cell suspension, a 10 microM concentration of MK-801 did not enhance the survival of tyrosine hydroxylase posit...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199805110-00011
更新日期:1998-05-11 00:00:00
abstract::We investigated the effect of the muscarinic acetylcholine receptor (mAChR) antagonist scopolamine on eyeblink conditioning in glutamate receptor subunit 62 null mice, which have severe impairments in cerebellar long-term depression (LTD). Mice were injected intraperitoneally with scopolamine (0.5 mg/kg) or saline, an...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200201210-00036
更新日期:2002-01-21 00:00:00
abstract::In previous studies, we demonstrated functional neuronal and dopaminergic differentiation of fetal mesencephalic neural precursor cells. The major factors for orienting their progeny towards a dopaminergic phenotype are forskolin and interleukin-1beta. Here, we investigated the effects of dexamethasone (10 microM) on ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000236862.08834.50
更新日期:2006-11-06 00:00:00
abstract::The aim of this study was to define the effects of a potent inhibitor of tyrosine phosphatases, sodium orthovanadate (0.1-100 microM for up to 48 h), on dentate gyrus cells (DGC) in culture. Treatment with 100 microM orthovanadate evoked a delayed form of cell death. To examine the possible involvement of apoptosis in...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199707280-00011
更新日期:1997-07-28 00:00:00
abstract::Episodic memory for simple commands is better following enacted than verbal encoding. This has been proposed to be due to the possibility to base retrieval on motor information. Here we used PET to test the hypothesis that motor brain areas show increased retrieval-related activity following enacted compared to verbal...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200007140-00027
更新日期:2000-07-14 00:00:00
abstract::Neural progenitor/stem cells reside in the subventricular zone and dentate gyrus of the adult rat brain, which proliferate in response to several growth factors. Here we show that the neurospheres generated from the adult dentate gyrus and subventricular zone proliferate in vitro in response to fibroblast growth facto...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200505310-00011
更新日期:2005-05-31 00:00:00
abstract::CEP-1347 inhibits the signalling pathway of c-jun-N-terminal kinase, and is neuroprotective in vivo and in vitro. Embryonic chick dorsal root ganglion neurones are dependent on NGF for survival and neurite outgrowth; NGF withdrawal results in apoptotic cell death. We examined the neuroprotective and neurite outgrowth ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000070828.57864.ad
更新日期:2003-05-23 00:00:00