Abstract:
:Numerous reports have shown that cyclin-dependent kinase 5 (Cdk5), a proline-directed serine/threonine kinase, critically contributes to the induction and maintenance of chronic pain induced by peripheral inflammation and nerve injury. Recent evidence has also suggested the critical role of an epigenetic mechanism in the setting of chronic pain. The present study aims to elucidate the cyclic AMP response element-binding protein (CREB)-mediated upregulation of Cdk5 and its functional significance in rats with neuropathic pain induced by chronic constriction injury (CCI) in the sciatic nerve. Significantly increased expression of Cdk5 was observed in the dorsal horn of rats with CCI, and intrathecal delivery of Cdk5 inhibitor roscovitine significantly attenuated the mechanical allodynia in these rats. Phosphorylation of CREB and its occupancy in the Cdk5 promoter region was also increased in the dorsal horn, which led to increased histone H4 acetylation in the Cdk5 promoter region and the upregulated transcription of Cdk5. Inhibition of CREB activity attenuated the upregulation of Cdk5 and alleviated the mechanical allodynia in rats with CCI. These results demonstrated a CREB-mediated epigenetic upregulation of Cdk5 in the dorsal horn, which critically contributed to the maintenance of painful behavior in the rats with neuropathic pain.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Li K,Zhao GQ,Li LY,Wu GZ,Cui SSdoi
10.1097/WNR.0000000000000237subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1116-21issue
14eissn
0959-4965issn
1473-558Xjournal_volume
25pub_type
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