Levels of beta-secretase BACE and alpha-secretase ADAM10 mRNAs in Alzheimer hippocampus.

abstract：:Recent studies have discussed the role of the cerebellum in not only motor but also cognitive functions, and in particular, fronto-executive operations. Similar to a previous study on hemineglect patients, we recorded eye movements during a visual search task to investigate patients with isolated infarction of the cer...

journal_title：Neuroreport

authors： Machner B,Sprenger A,Kömpf D,Heide W

更新日期：2005-09-08 00:00:00

abstract：:To investigate the origin of high-frequency somatosensory evoked potential (SEP) components, we recorded median nerve SEPs from the scalp and the depth in six monkeys. Laminar field potentials were analyzed in area 3b (N10; corresponding to human N20) and area 1 (P12; corresponding to human P25). After digital filteri...

journal_title：Neuroreport

authors： Shimazu H,Kaji R,Tsujimoto T,Kohara N,Ikeda A,Kimura J,Shibasaki H

更新日期：2000-08-21 00:00:00

abstract：:Inhibition, the process that overrides and reverses the execution of a thought, action, or emotion, is important in daily life. Sixteen healthy volunteers performed a parametrically modulated motor inhibition task during functional magnetic resonance imaging. Two results were observed: (1) increased error-related ante...

journal_title：Neuroreport

authors： Matthews SC,Simmons AN,Arce E,Paulus MP

更新日期：2005-05-12 00:00:00

abstract：:Subpopulations of olfactory receptor neurons, which are dispersed throughout the olfactory neuroepithelium, express specific cell surface carbohydrates and project to discrete regions of the olfactory bulb. Cell surface carbohydrates such as N-acetyl-lactosamine have been postulated to mediate sorting and selective fa...

journal_title：Neuroreport

authors： Puche AC,Bartlett PF,Key B

更新日期：1997-10-20 00:00:00

abstract：:Spontaneous saccades of both eyes were recorded in head-restrained pigeons placed in 6 different visual conditions (darkness and biocular, uniocular, frontal or lateral viewing). Most saccades (95%) were biocular and directed forward (around the beak axis) and backward (around the horizontal line). In the dark, the pr...

journal_title：Neuroreport

authors： Lemeignan M,Sansonetti A,Gioanni H

更新日期：1992-01-01 00:00:00

abstract：:The present study used the N400, an electrophysiological correlate of semantic processing, to investigate 19- and 24-month-old children's ability to integrate the meaning of words in a sentential context. Children listened passively to semantically appropriate sentences and to sentences in which the object noun violat...

journal_title：Neuroreport

authors： Friedrich M,Friederici AD

更新日期：2005-11-07 00:00:00

abstract：:Alpha oscillations during cognitive performance have mostly been studied in memory and/or basic attention tasks. This study investigates task-related alpha power desynchronization during an attentional switching task requiring higher executive attentional control. Low 8-10 Hz and high 10-12 Hz alpha power responses ar...

journal_title：Neuroreport

authors： Verstraeten E,Cluydts R

更新日期：2002-04-16 00:00:00

abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity reproduces many of the features of Parkinson's disease (PD). alpha-Synuclein has been identified as a prominent component of the Lewy body (LB), the pathological hallmark of PD. MPTP-treated primates have been reported to develop intraneuronal inclusion...

journal_title：Neuroreport

authors： Kowall NW,Hantraye P,Brouillet E,Beal MF,McKee AC,Ferrante RJ

更新日期：2000-01-17 00:00:00

abstract：:We investigated temporal relationships among EEG theta frequency, eye movement (EM) burst and phasic surge of arterial pressure (AP) during rapid eye movement (REM) sleep in six rats. Changes in EEG theta frequency, EM number, mean AP (MAP) and heart rate (HR) during 1 s bins were obtained with reference to the onset ...

journal_title：Neuroreport

authors： Sei H,Morita Y

更新日期：1996-11-25 00:00:00

abstract：:Evoked magnetic fields over the entire head were measured during a semantic judgment task, in which conditions of the pre-test learning session were manipulated. Subjects learnt related and unrelated category-noun pairs, and were then asked to judge the relationship between category and noun. Unrelated pairs evoked ac...

journal_title：Neuroreport

authors： Suzuki K,Okuda J,Otsuka Y,Sugawara A,Hatanaka K,Nakasato N,Kanno A,Yoshimoto T,Fujii T,Yamadori A

更新日期：2001-02-12 00:00:00

abstract：:Antisera were produced against synthetic peptides predicted from the recent cloning of a delta opioid receptor, DOR-1. Confocal microscopic examination of immunostained spinal cord sections revealed that DOR-1 immunoreactive (-ir) nerve fibers and terminals form a moderately dense plexus within the superficial dorsal ...

journal_title：Neuroreport

authors： Dado RJ,Law PY,Loh HH,Elde R

更新日期：1993-12-13 00:00:00

abstract：:It has been widely shown that recognition memory includes two distinct retrieval processes: familiarity and recollection. Many studies have shown that recognition memory can be facilitated when there is a perceptual match between the studied and the tested items. Most event-related potential studies have explored the ...

journal_title：Neuroreport

authors： Cui X,Gao C,Zhou J,Guo C

更新日期：2016-09-28 00:00:00

abstract：:We studied the neural substrate of anticipation and learning of smooth pursuit eye movements in humans using fMRI. Both predictable and non-predictable eye movements, compared to baseline, activated a common network previously associated with oculomotor function. The temporal dynamics of activity in a subset of these ...

journal_title：Neuroreport

authors： Schmid A,Rees G,Frith C,Barnes G

更新日期：2001-05-25 00:00:00

abstract：:Sex differences in event-related potentials were examined in 23 women and 24 men during a mental rotation task. We found an early (130-400 ms) and a late (400-700 ms) ERP mental rotation effect. The late rotation effect, which is thought to indicate the onset of the cognitive process of mental rotation, emerged about ...

journal_title：Neuroreport

authors： Gootjes L,Bruggeling EC,Magnée T,Van Strien JW

更新日期：2008-02-12 00:00:00

abstract：:Music is an essential communication tool that can convey emotional information. Segmentation of a sound stream of music at event boundaries is necessary for identification and extraction of musical context and features. To investigate recognition of music termination structure, or cadence, we composed music sequences ...

journal_title：Neuroreport

authors： Hoshi-Shiba R,Furukawa K,Okanoya K

更新日期：2014-07-09 00:00:00

abstract：:Administration of either a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801 (dizocilpine), or a muscarinic antagonist, scopolamine, produces dose-related impairments in performance of a visual recognition memory task, delayed non-matching to sample (DNMS) with lists of 20 symbols, in rhesus monk...

journal_title：Neuroreport

authors： Matsuoka N,Aigner TG

更新日期：1996-01-31 00:00:00

abstract：:This study tested whether adult rat brain stem neurons could respond to growth or trophic factors provided after an extended post-injury period. The number of neurons that regenerated their axon into a peripheral nerve graft following exposure to ciliary neurotrophic factor (CNTF) 8 weeks after a cervical lesion was c...

journal_title：Neuroreport

authors： Houle JD,Ye JH

更新日期：1997-02-10 00:00:00

abstract：:Latexin is a novel 29 kDa protein which is expressed in a subpopulation of neurones in the lateral cerebral cortex of adult rats. Here, we report the distribution of immunohistochemically detectable latexin in the rat brain during early phases of development. Latexin was first detected at embryonic day 11 (E11) along ...

journal_title：Neuroreport

authors： Takiguchi-Hayashi K,Arimatsu Y

更新日期：1995-01-26 00:00:00

abstract：:S100B is a calcium binding protein from astrocytes that regulates protein phosphorylation by binding to substrates and protein kinases. S100B might also regulate protein phosphatases and this was investigated for protein phosphatase 2B (calcineurin). The results indicate that S100B (5-10 microM) increased the activity...

journal_title：Neuroreport

authors： Leal RB,Frizzo JK,Tramontina F,Fieuw-Makaroff S,Bobrovskaya L,Dunkley PR,Gonçalves CA

更新日期：2004-02-09 00:00:00

abstract：:GABAA receptors mediate the inhibition of somatostatin release in hypothalamic neurones. To study the possible effect of GABA on somatostatin biosynthesis, somatostatin and preprosomatostatin mRNA levels were evaluated after exposure of hypothalamic neurones to muscimol or bicuculline. Muscimol (50 microM) decreased p...

journal_title：Neuroreport

authors： Rage F,Jalaguier S,Rougeot C,Tapia-Arancibia L

更新日期：1993-03-01 00:00:00

abstract：:Amyloid beta-peptide (Abeta) accumulation in aged Sprague-Dawley rats (12 months) with kaolin-induced hydrocephalus was investigated by Abeta(1-40) and Abeta(1-42) immunohistochemistry at 2, 6 and 10 weeks after induction. The low-density lipoprotein receptor-related protein-1 transporting Abeta across the blood-brain...

journal_title：Neuroreport

authors： Klinge PM,Samii A,Niescken S,Brinker T,Silverberg GD

更新日期：2006-04-24 00:00:00

abstract：:We examined the induction of progesterone receptor-immunoreactive (PR-ir) cells by estrogen in the rat preoptic area and ventromedial hypothalamic nucleus. Ovariectomized young (3-month-old) and old (24-month-old) female rats were treated with estrogen or cholesterol for 4 days. Estrogen significantly increased PR-ir ...

journal_title：Neuroreport

authors： Furuta M,Fukushima A,Chiba S,Sano A,Akema T,Kimura F,Funabashi T

更新日期：2010-08-04 00:00:00

abstract：:Previous studies have suggested that the dorsomedial prefrontal cortex (dmPFC) plays a central role in processing first impressions; however, little is known about how dmPFC processes different valences of first impressions. Moreover, it is still unclear as to whether the dmPFC shows lateralization or only induces dif...

journal_title：Neuroreport

authors： Yu CL,Wang MY,Hu JF

更新日期：2016-05-25 00:00:00

abstract：:The gene expression of cholecystokinin (CCK), a neuropeptide with anti-opioid properties, has been reported to be upregulated in some primary sensory neurons after a peripheral nerve lesion. We have recently demonstrated that the upregulation of CCK mRNA is not accompanied by an increased potassium-evoked release CCK-...

journal_title：Neuroreport

authors： Afrah AW,Gustafsson H,Olgart L,Brodin E,Stiller CO

更新日期：2001-01-22 00:00:00

abstract：:Following ventral root avulsion in neonatal animals, the degeneration of spinal motoneurons occurs by an apoptotic-like morphological pathway. In adult animals, however, the mechanism of degeneration of injured motoneurons is still controversial. Because caspases are important mediators of apoptosis, we have investiga...

journal_title：Neuroreport

authors： Chan YM,Wu W,Yip HK,So KF,Oppenheim RW

更新日期：2001-03-05 00:00:00

abstract：:In this study we have used the transgenic mouse model Tg2576 to analyze the involvement of anomalous loss of regulation of cdk5 and the stress kinases JNK and p38 in brain neuronal death as related to neurodegenerative disorders such as Alzheimer's disease. Previous studies on hippocampal cells led us to the discovery...

journal_title：Neuroreport

authors： Otth C,Mendoza-Naranjo A,Mujica L,Zambrano A,Concha II,Maccioni RB

更新日期：2003-12-19 00:00:00

abstract：:Auditory evoked magnetic fields were recorded with a 24-SQUID magnetometer on a patient with a vascular lesion in the right auditory cortex and its vicinity. The contralateral transient 100 ms response (N100m) was absent over the damaged side, with no recovery within 16 months. Responses were normal over the healthy s...

journal_title：Neuroreport

authors： Mäkelä JP,Hari R

更新日期：1992-01-01 00:00:00

abstract：:The time course of responses to repeated presentations of affective stimuli is well characterized in healthy individuals but remains to be characterized in patients with bipolar disorder. Using functional magnetic resonance imaging, we compared early-stage and late-stage brain activation during a two-block fearful fac...

journal_title：Neuroreport

authors： Killgore WD,Gruber SA,Yurgelun-Todd DA

更新日期：2008-10-08 00:00:00

abstract：:Reading is a learned skill that is likely influenced by both brain maturation and experience. Functional imaging studies have identified brain regions important for skilled reading, but the structural brain changes that co-occur with reading acquisition remain largely unknown. We investigated maturational volume chang...

journal_title：Neuroreport

authors： Houston SM,Lebel C,Katzir T,Manis FR,Kan E,Rodriguez GG,Sowell ER

更新日期：2014-03-26 00:00:00

abstract：:TECTA and DFNA5 are the mouse orthologues of the human deafness-associated genes TECTA and DFNA5. To determine how expression of these genes is regulated during development, relative mRNA abundance was examined in mice by non-radioactive RT-PCR. TECTA mRNA was detected on embryonic day 15 (E15), increased to its highe...

journal_title：Neuroreport

authors： Maeda Y,Fukushima K,Kasai N,Maeta M,Nishizaki K

更新日期：2001-10-29 00:00:00