Brain amyloid accumulates in aged rats with kaolin-induced hydrocephalus.

abstract：:Densities of serotonin transporters (5-HTT) in the postmortem neocortex of behaviorally assessed Alzheimer's disease (AD) patients and aged controls were measured by radioligand binding with [3H]citalopram. It was found that 5-HTT sites in the temporal cortex of AD patients with prominent antemortem anxiety were unalt...

journal_title：Neuroreport

authors： Tsang SW,Lai MK,Francis PT,Wong PT,Spence I,Esiri MM,Keene J,Hope T,Chen CP

更新日期：2003-07-18 00:00:00

abstract：:The mesocorticolimbic circuit projects to the prefrontal cortex, hippocampus, amygdala, and nucleus accumbens, among others, and it originates in the dopaminergic neurons of the ventral tegmental area (VTA). The VTA receives glutamatergic inputs from the prefrontal cortex and several subcortical regions. The glutamate...

journal_title：Neuroreport

authors： Ferrada C,Sotomayor-Zárate R,Abarca J,Gysling K

更新日期：2017-01-01 00:00:00

abstract：:We investigated the effects of 2,2,2-trichloroethanol (TCE), the active metabolite of chloral hydrate, on large-conductance calcium-activated K+ channels (BKCa channels) of dorsal root ganglion (DRG) neurones. In outside-out patches, 2 and 5 mM TCE increased the open probability of BKCa channels to 1.7-fold and 2.8-fo...

journal_title：Neuroreport

authors： Gruss M,Hempelmann G,Scholz A

更新日期：2002-05-07 00:00:00

abstract：:Expression of monocarboxylate transporter MCT1 was studied in archival tissues from human CNS using antibodies to the carboxyl-terminal end of MCT1. Sections of neocortex, hippocampus and cerebellum of brains from 10 adult autopsy patients who died from other than CNS disease, and from archival surgical biopsy specime...

journal_title：Neuroreport

authors： Froberg MK,Gerhart DZ,Enerson BE,Manivel C,Guzman-Paz M,Seacotte N,Drewes LR

更新日期：2001-03-26 00:00:00

abstract：:We investigated the age-related change in the distribution of a molecular marker for neural stem and precursor cells, Musashi-1, in the olfactory epithelium of mice from 1 day up to 16 months of age using immunohistochemistry. We also compared the distribution pattern of Musashi-1 with that of growth-associated protei...

journal_title：Neuroreport

authors： Watanabe K,Kondo K,Takeuchi N,Okano H,Yamasoba T

更新日期：2007-05-07 00:00:00

abstract：:The ventral cochlear tract in the brain stem to pons was transected on one side in two groups of adult rats. In one group simple transection was performed, while in the other group tissue from embryos (E14-E16) was used to cover the lesion site. While rats receiving simple transection without transplantation showed no...

journal_title：Neuroreport

authors： Ito J,Kawaguchi S,Murata M

更新日期：1998-12-01 00:00:00

abstract：:Reading is a learned skill that is likely influenced by both brain maturation and experience. Functional imaging studies have identified brain regions important for skilled reading, but the structural brain changes that co-occur with reading acquisition remain largely unknown. We investigated maturational volume chang...

journal_title：Neuroreport

authors： Houston SM,Lebel C,Katzir T,Manis FR,Kan E,Rodriguez GG,Sowell ER

更新日期：2014-03-26 00:00:00

abstract：:To investigate the origin of high-frequency somatosensory evoked potential (SEP) components, we recorded median nerve SEPs from the scalp and the depth in six monkeys. Laminar field potentials were analyzed in area 3b (N10; corresponding to human N20) and area 1 (P12; corresponding to human P25). After digital filteri...

journal_title：Neuroreport

authors： Shimazu H,Kaji R,Tsujimoto T,Kohara N,Ikeda A,Kimura J,Shibasaki H

更新日期：2000-08-21 00:00:00

abstract：:The aim of the present study was to examine the effects of nicotinamide, a co-factor in the electron transport chain, on the relationship between methamphetamine (MA)-induced striatal dopamine (DA) depletion and energy metabolism change. Four injections of MA (10 mg/kg, i.p.) at 2 h intervals resulted in decreases of ...

journal_title：Neuroreport

authors： Huang NK,Wan FJ,Tseng CJ,Tung CS

更新日期：1997-05-27 00:00:00

abstract：:We investigated the cardiovascular effects of bilateral microinjection of antisense oligodeoxynucleotides (oligos) into the nucleus tractus solitarii (NTS) to neuronal nitric oxide synthase (nNOS) to suppress the expression of nNOS molecular biologically. In urethane-anesthetized, paralyzed Wistar-Kyoto rats, bilatera...

journal_title：Neuroreport

authors： Maeda M,Hirano H,Kudo H,Doi Y,Higashi K,Fujimoto S

更新日期：1999-06-23 00:00:00

abstract：:This study examined 'prepulse inhibition' in the context of an auditory two-tone discrimination task performed by 15 healthy subjects. In order to distinguish between masking or excitatory information processes, weak acoustic pulses immediately preceded or succeeded a target or non-target tone in the discrimination. B...

journal_title：Neuroreport

authors： Schall U,Ward PB

更新日期：1996-01-31 00:00:00

abstract：OBJECTIVE:Birdsong sounds are often used to inform visually-challenged people about the presence of basic infrastructures, and therefore need to be salient in noisy urban environments. How salient sounds are processed in the brain could inform us about the optimal birdsong in such environments. However, brain activity ...

journal_title：Neuroreport

authors： Yano H,Soeta Y

更新日期：2021-01-13 00:00:00

abstract：:Resident microglial cells contribute to activation and expansion of T cells under inflammatory conditions within the CNS. However, there is no evidence how interactions between microglia and T cells affect CNS inflammation. We evaluated the effect of glial cell-derived dendritic cells (GC-DC) in expanding and eliminat...

journal_title：Neuroreport

authors： Xu LY,Yang JS,Xiao BG

更新日期：2002-01-21 00:00:00

abstract：:Human morning/evening preferences has recently been reported to be associated with polymorphism of the 3' flanking region of the Clock gene, which was the first identified mammalian circadian clock gene. We recorded body temperature, spontaneous activity, electroencephalogram and electromyogram for 48 h in mice with J...

journal_title：Neuroreport

authors： Sei H,Oishi K,Morita Y,Ishida N

更新日期：2001-05-25 00:00:00

abstract：:In the adult brain, neural proliferation is almost absent and neurons are generally not renewed. By contrast, in the olfactory organ, olfactory neurons are produced continuously throughout life. To investigate whether specific cell cycle inhibitors are involved in the control of neural quiescence in adulthood, we comp...

journal_title：Neuroreport

authors： Legrier ME,Ducray A,Propper A,Kastner A

更新日期：2001-10-08 00:00:00

abstract：:Tau protein phosphorylation has been implicated as a main process that regulates microtubule dynamics. A large number of tau isoforms is generated by phosphorylation through the action of a diversity of kinases. We have analysed variations in tau phosphorylation by two-dimensional gel electrophoresis, where a great he...

journal_title：Neuroreport

authors： Araujo HM,Sutton R,Moura Neto V

更新日期：1994-10-27 00:00:00

abstract：:We validated and used a high-performance liquid chromatography procedure for the determination of four different amino acid neurotransmitters in cultured rat neurons and used culture medium. Samples were derivatized using 2,4-dinitrofluorobenzene and the amino acids were separated on a C18 column. The method yielded g...

journal_title：Neuroreport

authors： Zhang F,Ma XL,Wang YX,Su RR,He C,Tian K,Liu YQ

更新日期：2016-05-04 00:00:00

abstract：:Regulation of CNTF mRNA was investigated in primary cortical astrocytes cultured from newborn rats and in C6 glioma cells. Northern blot analysis indicated that semi-confluent astrocyte cell cultures. CNTF added to confluent astrocyte cultures down-regulated CNTF message in a dose-dependent fashion. In contrast, when ...

journal_title：Neuroreport

authors： Meyer V,Unsicker K

更新日期：1994-10-03 00:00:00

abstract：:BC200 is a long noncoding RNA expressed at high levels in the Alzheimer's disease (AD), and blocking of BC200 by siRNA is assumed to be an effective method for various disease therapy. We have established an AD cell model overexpressing amyloid β-peptide (Aβ)1-42 to observe the effects of BC200 on the cell viability a...

journal_title：Neuroreport

authors： Li H,Zheng L,Jiang A,Mo Y,Gong Q

更新日期：2018-09-05 00:00:00

abstract：:In situ hybridization has demonstrated mRNA for olfactory receptors (OR) in the axon terminals of olfactory receptor neurons. Neurons that express the same OR appear to send their axons to two stereotyped glomeruli in the olfactory bulb (OB). Based on these observations, we tested the feasibility of using RT-PCR to is...

journal_title：Neuroreport

authors： Singer MS,Hughes TE,Shepherd GM,Greer CA

更新日期：1998-11-16 00:00:00

abstract：:Cisplatin is a widely used chemotherapeutic drug, but one of its side effects is ototoxicity. Epigenetic-related drugs, such as lysine-specific demethylase 1 (LSD1) inhibitors, have been reported to protect against cisplatin-induced hair cell loss by preventing demethylation of histone H3K4 (H3K4me2). However, the pro...

journal_title：Neuroreport

authors： Li A,He Y,Sun S,Cai C,Li H

更新日期：2015-06-17 00:00:00

abstract：:Insulin-like growth factor-1 (IGF-1) and erythropoietin (EPO) are induced in brain cells after brain ischemia and show synergistic neuroprotective effects. In LN215 astrocytoma cells, IGF-1 induced the activation of hypoxia-inducible factor-1, leading to increases in EPO mRNA levels and the secretion of EPO. Interesti...

journal_title：Neuroreport

authors： Kim I,Kim CH,Yim YS,Ahn YS

更新日期：2008-11-19 00:00:00

abstract：:Transcranial direct current stimulation (tDCS) was used in 17 normal individuals to modulate vestibulo-ocular reflex (VOR) and self-motion perception rotational thresholds. The electrodes were applied over the temporoparietal junction bilaterally. Both vestibular nystagmic and perceptual thresholds were increased duri...

journal_title：Neuroreport

authors： Kyriakareli A,Cousins S,Pettorossi VE,Bronstein AM

更新日期：2013-10-02 00:00:00

abstract：:Sulphated cholecystokinin-8 (CCK-8) given into the neostriatum of the rat by in vivo microdialysis produced a concentration-dependent (1-100 microM) increase in extracellular aspartate (Asp) and dynorphin B (Dyn B), but not in glutamate, GABA or dopamine levels. The increase in Asp levels produced by 10 microM CCK-8 w...

journal_title：Neuroreport

authors： You ZB,Pettersson E,Herrera-Marschitz M,Hökfelt T,Terenius L,Nylander I,Goiny M,Hughes J,O'Connor WT,Ungerstedt U

更新日期：1994-11-21 00:00:00

abstract：:6-Aminonicotinamide (6-AN) is thought to inhibit the pentose phosphate pathway (PPP) since large increases in 6-phosphogluconate are observed following its administration. Immediately following 45 min i.v. infusion of [2-(13)C]glucose to controls and 6-AN-treated (50 mg/kg i.p. given 4 h previously) Sprague-Dawley rat...

journal_title：Neuroreport

authors： Tyson RL,Perron J,Sutherland GR

更新日期：2000-06-26 00:00:00

abstract：:The effects of copper on voltage-gated A-type potassium currents were investigated in acutely dissociated rat hippocampal CA1 neurons using the whole-cell patch-clamp technique. Extracellular application of various concentrations of copper (1-1000 microM) reversibly reduced the amplitude of voltage-gated A-type potass...

journal_title：Neuroreport

authors： Niu ZD,Yu K,Gu Y,Wang M,She JQ,Chen WH,Ruan DY

更新日期：2005-09-28 00:00:00

abstract：:Single-pulse unilateral electrical stimulation of either the amygdala or the inferior colliculus elicited startle-like responses in chloral hydrate anesthetized rats. EMG responses to intracranial stimulation were recorded from the anterior biceps femoris muscles. The EMG responses were generally enhanced following un...

journal_title：Neuroreport

authors： Lin C,Wan X,Zhao W,Ma C,Ma C,Gao Y,Zhou Y,Yeomans JS,Li L

更新日期：2002-10-07 00:00:00

abstract：:This study demonstrates the neural system potentially involved in the representation of, and choice between, stimulus classifications in an ambiguous, novel, decision-making task. This difficult choice behaviour is taken as an example of a basic executive processing task. Subjects heard sounds that were consonant-vowe...

journal_title：Neuroreport

authors： Scott SK,Holmes A,Friston KJ,Wise RJ

更新日期：2000-05-15 00:00:00

abstract：:In previous studies, we demonstrated functional neuronal and dopaminergic differentiation of fetal mesencephalic neural precursor cells. The major factors for orienting their progeny towards a dopaminergic phenotype are forskolin and interleukin-1beta. Here, we investigated the effects of dexamethasone (10 microM) on ...

journal_title：Neuroreport

authors： Sabolek M,Herborg A,Schwarz J,Storch A

更新日期：2006-11-06 00:00:00

abstract：:In an attempt to determine whether small focal malformations of the neocortex can be visualized in vivo, focal microgyria were induced in the neocortex of otherwise normal rats by freezing injury to the developing cortical plate, and in adulthood the malformation was visualized using MRI. Induced microgyria of varying...

journal_title：Neuroreport

authors： Rosen GD,Burstein D

更新日期：1997-12-22 00:00:00