Trichloroethanol alters action potentials in a subgroup of primary sensory neurones.

Abstract:

:We investigated the effects of 2,2,2-trichloroethanol (TCE), the active metabolite of chloral hydrate, on large-conductance calcium-activated K+ channels (BKCa channels) of dorsal root ganglion (DRG) neurones. In outside-out patches, 2 and 5 mM TCE increased the open probability of BKCa channels to 1.7-fold and 2.8-fold of control, respectively. In 50% of the cells investigated (group A) the action potential (AP) was shortened reversibly by TCE by 20% and the whole-cell outward-current was increased by 44%. Both effects could be antagonized by iberiotoxin. In a second group of neurone (group B), TCE prolonged the AP duration. The effects of TCE in group A, which was 20-fold more potent than ethanol on BKCa channels and AP might contribute to the described analgesic effect of chloral hydrate.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Gruss M,Hempelmann G,Scholz A

doi

10.1097/00001756-200205070-00023

subject

Has Abstract

pub_date

2002-05-07 00:00:00

pages

853-6

issue

6

eissn

0959-4965

issn

1473-558X

journal_volume

13

pub_type

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