Abstract:
:Astrogliosis is an important component of the response to injury of the central nervous system (CNS). The Id family of helix-loop-helix (HLH) transcription factors has been implicated in the regulation of cellular differentiation in several different lineages and may contribute to the regulation of astrogliosis. We examined the expression of Id genes in primary cultures of mouse forebrain astrocytes under experimental conditions in which astrogliosis was elicited by mechanical injury. Astrocyte cultures expressed the four known members of the Id gene family, Id1, Id2, Id3, and Id4. After injury, at a time when astrocytes developed the characteristic phenotypic changes of astrogliosis, Id4 expression decreased dramatically. Id1, Id2, and Id3 mRNA levels did not change. These results identify Id4 as a candidate marker of astroglial activation in culture and suggest that Id4 expression plays a role in the process of astrogliosis.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Andres-Barquin PJ,Hernandez MC,Israel MAdoi
10.1097/00001756-199812210-00013subject
Has Abstractpub_date
1998-12-21 00:00:00pages
4075-80issue
18eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
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