Abstract:
:Disturbances in methyl-carbon metabolism, which result in hyperhomocysteinemia, have been associated with schizophrenia. Homozygosity for the T677 allele of the methylenetetrahydrofolate reductase (MTHFR) gene, which encodes for a thermolabile enzyme associated with hyperhomocysteinemia, has been found to be increased in schizophrenic patients. We have investigated whether plasma homocysteine concentration and the frequency of C677T MTHFR variant were increased in schizophrenic inpatients of a psychiatric hospital (n=210) compared with controls (n=218). There were no significant differences in plasma homocysteine concentrations between the schizophrenia and the control group. The distributions of T allele and TT genotype frequencies were similar in both groups (40% and 15%). These results show that impaired homocysteine metabolism is unlikely in schizophrenia.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Virgos C,Martorell L,Simó JM,Valero J,Figuera L,Joven J,Labad A,Vilella Edoi
10.1097/00001756-199907130-00008subject
Has Abstractpub_date
1999-07-13 00:00:00pages
2035-8issue
10eissn
0959-4965issn
1473-558Xjournal_volume
10pub_type
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